ID   VOSA_USTMA              Reviewed;         814 AA.
AC   A0A0D1E9B9;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2015, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Spore development regulator umv1 {ECO:0000305};
GN   Name=umv1 {ECO:0000303|PubMed:24064149}; ORFNames=UMAG_00893;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24064149; DOI=10.1016/j.fgb.2013.09.002;
RA   Karakkat B.B., Gold S.E., Covert S.F.;
RT   "Two members of the Ustilago maydis velvet family influence teliospore
RT   development and virulence on maize seedlings.";
RL   Fungal Genet. Biol. 61:111-119(2013).
CC   -!- FUNCTION: Component of the velB-VosA heterodimeric complex that plays a
CC       dual role in activating genes associated with spore maturation and
CC       repressing certain development-associated genes (By similarity). The
CC       complex binds DNA through the DNA-binding domain of vosA that
CC       recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3'
CC       consisting of two motifs in the promoters of key developmental
CC       regulatory genes (By similarity). Required for gall induction and
CC       teliospore formation on seedlings (PubMed:24064149).
CC       {ECO:0000250|UniProtKB:Q5BBX1, ECO:0000269|PubMed:24064149}.
CC   -!- SUBUNIT: Forms a heterodimeric complex with velB; the formation of the
CC       VEL2-VOS1 complex is light-dependent (By similarity).
CC       {ECO:0000250|UniProtKB:Q5BBX1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5BBX1}.
CC   -!- DOMAIN: The N-terminal velvet domain contains a NF-kappa-B-like fold
CC       and is involved in DNA-binding (By similarity).
CC       {ECO:0000250|UniProtKB:Q5BBX1}.
CC   -!- DISRUPTION PHENOTYPE: Leads to reduced virulence (PubMed:24064149).
CC       {ECO:0000269|PubMed:24064149}.
CC   -!- SIMILARITY: Belongs to the velvet family. VosA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CM003141; KIS70975.1; -; Genomic_DNA.
DR   RefSeq; XP_011386908.1; XM_011388606.1.
DR   AlphaFoldDB; A0A0D1E9B9; -.
DR   SMR; A0A0D1E9B9; -.
DR   EnsemblFungi; KIS70975; KIS70975; UMAG_00893.
DR   GeneID; 23562064; -.
DR   KEGG; uma:UMAG_00893; -.
DR   VEuPathDB; FungiDB:UMAG_00893; -.
DR   eggNOG; ENOG502S0HV; Eukaryota.
DR   OMA; WYLENPY; -.
DR   OrthoDB; 1407766at2759; -.
DR   Proteomes; UP000000561; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3960; -; 1.
DR   InterPro; IPR021740; Velvet.
DR   InterPro; IPR037525; Velvet_dom.
DR   InterPro; IPR038491; Velvet_dom_sf.
DR   PANTHER; PTHR33572; PTHR33572; 1.
DR   Pfam; PF11754; Velvet; 2.
DR   PROSITE; PS51821; VELVET; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..814
FT                   /note="Spore development regulator umv1"
FT                   /id="PRO_0000435914"
FT   DOMAIN          53..274
FT                   /note="Velvet"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          457..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          539..814
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           438..445
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:M2TGT8"
FT   COMPBIAS        284..308
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        719..735
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        760..791
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        800..814
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   814 AA;  90382 MW;  1B5523F4566C7802 CRC64;
     MSRPESRSGN ASTPQGTSVL KADDGGSGQT PGGSTENSVA YRYVAVQQMT SCRDHIEYQL
     TVREQPKQSR MCGVGEKADR RPIDPAPIVQ LRVVTHDRPI RQSDPVGSAS VAPPVERRPG
     QGAAAPQTPG VRRGLPVTTA LGDGWEDKAW YLENPYYFMY AMLCNADTDE ELHLLNDGKT
     RYTSGSCVSC LYHLKDIDGS HQGFFVFPDL SIRVEGRYRL KLCLFETIGH SVHHCKSIYS
     DPFHVYTAKR FPGMEESTRL SKSFAEQGLK VRVRKHPRSR RRGSKRTKDE SDASDETPLA
     RHVSPKRARA SDVLPMSGLP MSQPIASSRM PRSMDDRFER ADYDRTPSMA SAYYDVKGAP
     PSRHAPWEEE EVLRLRESRA WDPMYDAPSA LYSHHAREDR VEDRRLPPRD FADGRYMDGD
     YPPHTRSAAA PLSSMSARAG PSEYSEHVRS VYLRDDPVRS MHGSPHRLSA ALPPLPPPLS
     KTPSHPALVG RGYPESSASL TPAYSRNYPS VPAPAPAPAP MPMRPAPLLS RSYDHIGQQS
     SGRIYDDYGP RPNVVAHYSG SYDPRDALAR GFSPPSPQPG RRSPYASHHP PTQWRSGPPS
     PSRPSDYHLG RASAVERGYA AARRSPIPSA RGIDTPPEAY AGFESNPFPR RSFGVPDAGR
     PAATYDAPRA PPADLYAPDE GPPSGRLGGI GFAPSSRERL ILPPLPVPSP LSAHRGELTP
     LGTRDRDREA AYIAMPRDRD QGLAPTERYL SPSGYNPRAG ELDQRDREWE WECERERERE
     RERKRGPASP EYRRDFAQAT MPSKPSSRGH NQPY