ID   VP10_CTFVL              Reviewed;         605 AA.
AC   Q9ENK7;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   23-FEB-2022, entry version 38.
DE   RecName: Full=Microtubule-associated protein VP10;
OS   Colorado tick fever virus (strain USA/Florio N-7180) (CTFV).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Coltivirus;
OC   Colorado tick fever coltivirus.
OX   NCBI_TaxID=648168;
OH   NCBI_TaxID=76772; Callospermophilus lateralis (Golden-mantled ground squirrel) (Spermophilus lateralis).
OH   NCBI_TaxID=34620; Dermacentor andersoni (Rocky mountain wood tick).
OH   NCBI_TaxID=34844; Erethizon dorsatum (North American porcupine).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=105147; Neotoma cinerea (Bushy-tailed woodrat).
OH   NCBI_TaxID=10042; Peromyscus maniculatus (North American deer mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=10891382; DOI=10.1006/bbrc.2000.3057;
RA   Attoui H., Billoir F., Biagini P., Cantaloube J.F., de Chesse R.,
RA   de Micco P., de Lamballerie X.;
RT   "Sequence determination and analysis of the full-length genome of colorado
RT   tick fever virus, the type species of genus Coltivirus (Family
RT   Reoviridae).";
RL   Biochem. Biophys. Res. Commun. 273:1121-1125(2000).
CC   -!- FUNCTION: Minor inner capsid component. Displays NTPase and RNA 5'-
CC       triphosphatase (RTPase) activities. May function as a cofactor of
CC       polymerase VP1. Associates with microtubules and plays a role in the
CC       formation, structural organization and morphology of viral inclusions,
CC       where the assembly of cores and the replication of viral RNA occur (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with VP1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm, host
CC       cytoskeleton {ECO:0000250}.
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DR   EMBL; AF139765; AAG00074.1; -; Genomic_RNA.
DR   RefSeq; NP_690899.1; NC_004189.1.
DR   GeneID; 993317; -.
DR   KEGG; vg:993317; -.
DR   Proteomes; UP000001675; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host cytoskeleton; Reference proteome; Virion.
FT   CHAIN           1..605
FT                   /note="Microtubule-associated protein VP10"
FT                   /id="PRO_0000403199"
SQ   SEQUENCE   605 AA;  68906 MW;  F5976D35860E1F53 CRC64;
     MLKRPAYYNI FLLPTGRRLA KTYNILENLI TLPKTDWKLY ETIEQKLKWM IQEYRSDWRD
     RLSHHERYGM KVRLTYRSES ERTKLEEKIT DLVISHGKKA STVHFCTRES YKGRVRANQI
     LILLEPEGLG EVEGLTVRAE GNWMSLVTHC LFILGSTLTC FGFVDPARGC RFNLLPYIKT
     LHPNDKWLLD LQASWRLEYG VSRSIEEGAL YDFFAESHTL YAVRTWPGCE KYLGALEAFV
     GRLAVLPAQV LTSKEHDFQS KLMSKAKKTG FHYLYYLVSF TMKTSLTDRI VKEALATVKV
     FSFVVGRDHL PAVGVYSGED FSKQFLSMAV GTMDTPSRYA ITIVSGMQVD VDVKSVTGIA
     SFKDGTQHTI VDEILLQPAR LVLLGRKGGG KSRLSKIFSE LGYNVLDSDT YGKVLTLVAD
     RGEDGLDDAL KKFVRLTPDE RKAVPSIFET EMDRLCEVFG SRGLRPYAQR CQQQAGRLHW
     ELYAAFQEFY DRTIRVITPD KFRFAYFAEL ERGGFDDNGL TFSPELKTVV FVHSMPELFE
     AMGGCVAEIV PTHSTRLAIL LRGQGLSVNA ELHLHDFYVA LNQNGARKVS LGWLVHALNE
     LLKMR