ID   VP12_CTFVL              Reviewed;         185 AA.
AC   Q66262;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-JUN-2021, entry version 41.
DE   RecName: Full=Uncharacterized protein VP12;
DE   Flags: Precursor;
OS   Colorado tick fever virus (strain USA/Florio N-7180) (CTFV).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Coltivirus;
OC   Colorado tick fever coltivirus.
OX   NCBI_TaxID=648168;
OH   NCBI_TaxID=76772; Callospermophilus lateralis (Golden-mantled ground squirrel) (Spermophilus lateralis).
OH   NCBI_TaxID=34620; Dermacentor andersoni (Rocky mountain wood tick).
OH   NCBI_TaxID=34844; Erethizon dorsatum (North American porcupine).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=105147; Neotoma cinerea (Bushy-tailed woodrat).
OH   NCBI_TaxID=10042; Peromyscus maniculatus (North American deer mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15269364; DOI=10.1099/vir.0.80019-0;
RA   Mohd Jaafar F., Attoui H., De Micco P., De Lamballerie X.;
RT   "Termination and read-through proteins encoded by genome segment 9 of
RT   Colorado tick fever virus.";
RL   J. Gen. Virol. 85:2237-2244(2004).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; U53227; AAB88233.1; -; Genomic_RNA.
DR   RefSeq; NP_690900.1; NC_004190.1.
DR   GeneID; 993318; -.
DR   KEGG; vg:993318; -.
DR   Proteomes; UP000001675; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..185
FT                   /note="Uncharacterized protein VP12"
FT                   /id="PRO_0000403201"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          96..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..114
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..158
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   185 AA;  20410 MW;  DA1991E5C86A827B CRC64;
     MPCNRAVFGA FVLALLISLQ SVYFKLYEFY KNNETARNTS VAGFLKRHEV AVNVIVEFSF
     DILFFLCGLL GFELSPTARR LIFRRTASAE KADTVELEHV SSRRRNDSRD DSTVRNVSKT
     SPLASQRSRD HFDGDPREPA PPAYSPADFY PPPASPHICE TPLSTRVAPS APSASLFTAG
     GIGLP