VP13A_DICDI
ID VP13A_DICDI Reviewed; 3373 AA.
AC Q54LB8;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Intermembrane lipid transfer protein vps13A {ECO:0000250|UniProtKB:Q96RL7};
DE AltName: Full=Vacuolar protein sorting-associated protein 13A {ECO:0000305};
GN Name=vps13A; ORFNames=DDB_G0286725;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites. {ECO:0000250|UniProtKB:Q07878}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Down-regulated by phagocytic stimuli.
CC {ECO:0000269|PubMed:18559084}.
CC -!- SIMILARITY: Belongs to the VPS13 family. {ECO:0000305}.
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DR EMBL; AAFI02000089; EAL64118.1; -; Genomic_DNA.
DR RefSeq; XP_637643.1; XM_632551.1.
DR STRING; 44689.DDB0234198; -.
DR PaxDb; Q54LB8; -.
DR PRIDE; Q54LB8; -.
DR EnsemblProtists; EAL64118; EAL64118; DDB_G0286725.
DR GeneID; 8625784; -.
DR KEGG; ddi:DDB_G0286725; -.
DR dictyBase; DDB_G0286725; vps13A.
DR eggNOG; KOG1796; Eukaryota.
DR eggNOG; KOG1809; Eukaryota.
DR HOGENOM; CLU_000135_1_0_1; -.
DR InParanoid; Q54LB8; -.
DR OMA; VDVRDWS; -.
DR PhylomeDB; Q54LB8; -.
DR PRO; PR:Q54LB8; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0005811; C:lipid droplet; ISS:UniProtKB.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR InterPro; IPR015412; Autophagy-rel_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_C.
DR InterPro; IPR031642; VPS13_mid_rpt.
DR InterPro; IPR031646; VPS13_N2.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166; PTHR16166; 1.
DR Pfam; PF09333; ATG_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF06650; SHR-BD; 1.
DR Pfam; PF16908; VPS13; 1.
DR Pfam; PF16909; VPS13_C; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
PE 2: Evidence at transcript level;
KW Lipid transport; Membrane; Reference proteome; Transport.
FT CHAIN 1..3373
FT /note="Intermembrane lipid transfer protein vps13A"
FT /id="PRO_0000365952"
FT DOMAIN 3..119
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000255"
FT DOMAIN 2405..2706
FT /note="SHR-BD"
FT /evidence="ECO:0000255"
FT REGION 818..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..1729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1872..1913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2909..2933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1081
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1273..1287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1288..1304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1656..1719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3373 AA; 379780 MW; 56183775B0D765C9 CRC64;
MVFEGLVSDV LSRVLGEYVK NLNKDQLKIG IFGGSVQLQN LELKEDALAN LPINLPITVK
KGFLGKLDLK VPWKDLKSKP VIINIDCIYA LAVPQTQNYK YDEKEEAKKQ AELKKKKLEN
YEWIKSIKDA EENEISSLQS EKSDSFTDRL VTKIIDNLQI VINKVHIRFE NKNDIGKLYA
LGITLDKLSI QSTDEFWIPS FVDSSKSKFI KKLALMDSLG FYIDDNADSL QNLKLDEFTK
AFTSLIPSSA SFSLLSKYII KPISSQLKLN INKSDIIEKS IPKILVECVM SQITCTLSSG
QYQNILSILN FTNEYLRDIK YLKFRPIVKV SENPKLWWRY VGQVIVEQIR EKRFSRSWEF
IAQRRRARLA YIPLFKRNIP KVDWLQPLNK HELEQLNQLE ERLSFEDIVY FRSLAYAEIK
KETEKNKIRK QFLDSKRQER GFFQNIFNTK KDEDEKAAPK IQLSSEERDE LYKTIEYNDV
VSASEEPPDW VKIIGNFEIK GFAIQLVEAN QVFIEALYTG LSLKFEQRNE GIKVMAGIHL
FEVYDQFTKR THFPKIIASV PTKGTGTFAS VIVDTRPPDK NLDLSVELNM DPLNIIVTKP
LIMKVVDFFH DPNLDITNIS NRAGAHLEDI KEQAKMQLQD AIDNHKVLGL AVNIHAPVIF
IPEDVINERS NILIVDLGKL VVRSDTSAFV KGSNKLAGST SEIDLYDKFN VSFESIQVLL
SDDLKSAIST GDKKPPTIGG VNDKQGHPLK HHNSIIKKFD IQLKIFSSIQ QNNLTMTKLK
IKGELPKFDF YLSDKKFKQL LTILNAITAD IPVTSGKPKA TITPINDSNS PSSVSPKLIS
TSPHSFSSSS APVDVNSSND LKKSKENIEL LLNAKLVEAE FEIKSISLTL SNNQSDLIRV
VFSDINVGFQ QRTFDMSGTF KLSSLEIEDC FTKNTLNKLA TSNPPHADRS LGKDSLVQMH
FKQIQTASPE FNKIDMSIDL KIHSFYLVIN PSTIYQLLKL AKSLQKDPEN IDQISKAYPR
LLSRNKVVPI NSSEGGGTAA TSPNAHLSSP NQQSPNQQSP NQQSPQIVSR KIITGTGSNS
KPVGPDEKVV SSKTASGTTT RRVIIRSVRH VPKKKGPTEF VSMKFSVHIN SLGLALNQDN
NELLGIFTIN NVSTDVSMFK DNRMLVQGRL GSIILDDLTP TISNYKQIII PKNTSGDMLD
FKYETFSMTL SNYAGYDASV NANVKSILFN ANVGFLIHLQ NYFLGGMLDP ILKQDDSNNN
NKSIEKSKSI DSKLNEQQSS SSSTSTPRSD DNHEKSEREL DLEKNKKLLT SLQQNTNKHI
PKMKLDIVVE TPVLVIPQAT RSKNSLIMEL GKIIISNGWQ YHDKTMAPME NMKIHLQDAN
ITILSDNRSS YFLEKLTIDL GISKFLVPNT DPEVEDQTID LSISHFAFYL DENQYRFFLG
LSQNVQKELD LANKEVQEIK KLSNMGDPFE MGRITSNDMQ YFTEQEVIQK MGKVLLRIHL
VLDYVSFKIS SLDAQGEIAH FIVRGIDVDV KNTDKNKTNI QLSMKSILLS DTRSNSTNIF
KNLLENKVNT ESVAPFLQVG YIRDNLLGDQ YINVNINNTC LFLSPTPLLM ISEFFMVPLS
EQHDTNNMDV DLDLDLESLE SELNSLMDPS IEKDDNDLQQ QQQQSSSSSF IPSQQQQQQK
VRSQSIIGQN RSRTSSIGGK ESKTISSSIS NNSLSSYPQE AGMEDEEEKE IFRSPTITFT
ATLVPSVTLV EDETLSTTRC LMLKTRVGVQ FRRDPHGIEN ATVVIENTKV NIYKPSSTES
ENQGSRPIQI LKPIEMITIK YIKENLTSTE WKQDIGISCT AMKVFFSYDD VKAILKILNN
ITTNLQKQQE QQKKRQLSFD NMASSSTSLP SLNKSTNSFQ TSTSGNSNSG KKDEELFTNN
EKLRFSCPNV SVLFINESPE MYIPIIELFF ADIEASAMNW STDLESKASM SIKGDYFNET
NMKFEPVIED WSFSVDLKKN RTGKIKGSFL ATRELLNINV SHSLLQTISS AMIHVEKIDQ
MDAANLSSSL NASNLTTSTG SNNSSTSGSG LVQSFNGPSV LNKYLPGGEK NDSKISFHSH
WISNQTGVTL EYHIPKVDSE MFQLTESSEP VSLPMKISKS RDATMGEHLN IELFIQGSKI
SNLSMDAVGY RIYRIGSTNE FITCEVRLRP DGSKCCYIKS MDQFENNTSL NLELKCQENG
SPFSIAKHSK FSLPILVSKD LCKFWIKLEN SPYWSDPIDI YKLPDHENSK LFKLQTVDKV
GMFVSLVHKT IANRNCDRFN NTFKFFPPIQ IENILPYPFK LSIPGTTIDK VNMGSGEKID
CHYYQPGSNL VAIVSELENF PETKHTLVSG DATSPTFTKT FKLQQNNREI SLDIERTELI
KGVRTLSFYC QYWLVNNSLL PIEVKLSDNQ VLLVPPNLPD QLPRPPVLYS NNTIRARIPL
QAEQPMNKSF CEKFPISAVG NPNTIFLTNP TRTYELSYKV DFCPNERFRL SKTVTFVPKN
VICNDLPFPI LVAQCVSTID GIDKMALNFS GSGLSSSSGS NGKGVSNPVR LLGELRLDPG
EYKPFHWEEN VENKKISIRP ITNEKNPQEW RWSGGFFVDS ISDYVVKSRN TERPDHDSLL
FHVNIKEKQG THFIRIPLSS KESPPYIIQN DTQFKISFFQ RDSPENIDYI EPKEKLCYGW
DEPSAEYVLS VAVEGKTLKK RINVNKIKGY KLQHERTDLY ITITIDGPSR VLLFSTNEKK
FRSIKAWTDN KAVNLSQSQS EYHFNIRCSG IGCSIIDKTP KELAYISMKD FLIIATQSSI
ENTVEVKLAE LQIDNQLIKT DFPVLIHTVS PDKEHRKDFL HAVIIKSTID NIDYFRYFST
LIQEMTIELE DHWIKEVLDF VDSIPSFGRG NNASNNNNNN GMTSSQMRQS GSGLDSLTST
LYNAVSIEPP TSDSSTIKMV YFALLVLNPI KINLTLALQN DGLIKSNHKI LSLVEGLGLS
LTRLDRAPIT LQGLLMEHPF TSRSTIIDKI KTSYIQQALR QFYNILGSVD FLGNPVGLFR
NFGTGVHDFF VEPAQGLVKS PADFTKGLAK GTSSFVKNSV FGTFNTLSKL TGTLGTGVAT
LSFDEKYLQE RKLHQARKPS HVGEGLAMGG IGLGRGILQG ITGIVTKPVE GAKKGGFAGF
AKGLAQGVVG VAVKPTTAVI DLATKTTEGI KNTTNLQSQA ERVRPPRCFS HDNVLRPFDE
VESEGWFLLK TAHKGKHASD SYIWHHIINQ ECTIIISDHR IILSKSKKNF LHSSFLFQIP
FKFIKSNEMV DDGVLLEFDP PQNLGLLDRD VKSKVIPVDD PNVNMLLNMK LSHALKKFHD
NNPNLSNSSS IKY
