VP13B_MOUSE
ID VP13B_MOUSE Reviewed; 3993 AA.
AC Q80TY5; E9QKX5;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2017, sequence version 3.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Intermembrane lipid transfer protein VPS13B {ECO:0000305};
DE AltName: Full=Cohen syndrome protein 1 homolog;
DE AltName: Full=Vacuolar protein sorting-associated protein 13B;
GN Name=Vps13b; Synonyms=Coh1, Kiaa0532;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2391-3993.
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=19006247; DOI=10.1002/humu.20886;
RA Seifert W., Holder-Espinasse M., Kuehnisch J., Kahrizi K., Tzschach A.,
RA Garshasbi M., Najmabadi H., Walter Kuss A., Kress W., Laureys G., Loeys B.,
RA Brilstra E., Mancini G.M.S., Dollfus H., Dahan K., Apse K., Hennies H.C.,
RA Horn D.;
RT "Expanded mutational spectrum in Cohen syndrome, tissue expression, and
RT transcript variants of COH1.";
RL Hum. Mutat. 30:E404-E420(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites. {ECO:0000250|UniProtKB:Q07878}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed in all examined tissues.
CC {ECO:0000269|PubMed:19006247}.
CC -!- SIMILARITY: Belongs to the VPS13 family. {ECO:0000305}.
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DR EMBL; AC121598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC122241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC144772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC157521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC166356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK122302; BAC65584.1; -; mRNA.
DR CCDS; CCDS49592.1; -.
DR RefSeq; NP_796125.2; NM_177151.3.
DR BioGRID; 578014; 4.
DR STRING; 10090.ENSMUSP00000045490; -.
DR iPTMnet; Q80TY5; -.
DR PhosphoSitePlus; Q80TY5; -.
DR MaxQB; Q80TY5; -.
DR PaxDb; Q80TY5; -.
DR PRIDE; Q80TY5; -.
DR ProteomicsDB; 275181; -.
DR Antibodypedia; 26091; 94 antibodies from 24 providers.
DR Ensembl; ENSMUST00000048646; ENSMUSP00000045490; ENSMUSG00000037646.
DR GeneID; 666173; -.
DR KEGG; mmu:666173; -.
DR CTD; 157680; -.
DR MGI; MGI:1916380; Vps13b.
DR VEuPathDB; HostDB:ENSMUSG00000037646; -.
DR eggNOG; KOG1809; Eukaryota.
DR GeneTree; ENSGT00940000154684; -.
DR InParanoid; Q80TY5; -.
DR OMA; FDFIMIY; -.
DR OrthoDB; 82489at2759; -.
DR PhylomeDB; Q80TY5; -.
DR TreeFam; TF323503; -.
DR BioGRID-ORCS; 666173; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Vps13b; mouse.
DR PRO; PR:Q80TY5; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q80TY5; protein.
DR Bgee; ENSMUSG00000037646; Expressed in paneth cell and 219 other tissues.
DR ExpressionAtlas; Q80TY5; baseline and differential.
DR Genevisible; E9QKX5; MM.
DR GO; GO:0002080; C:acrosomal membrane; IDA:UniProtKB.
DR GO; GO:0033106; C:cis-Golgi network membrane; ISS:UniProtKB.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; ISS:UniProtKB.
DR GO; GO:0032588; C:trans-Golgi network membrane; ISS:UniProtKB.
DR GO; GO:0001675; P:acrosome assembly; IMP:UniProtKB.
DR GO; GO:0060612; P:adipose tissue development; ISS:UniProtKB.
DR GO; GO:0007417; P:central nervous system development; IMP:UniProtKB.
DR GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
DR GO; GO:0090168; P:Golgi reassembly; ISS:UniProtKB.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_C.
DR InterPro; IPR009543; VPS13_VAB.
DR InterPro; IPR039782; VPS13B.
DR PANTHER; PTHR12517; PTHR12517; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF06650; SHR-BD; 1.
DR Pfam; PF16909; VPS13_C; 1.
PE 1: Evidence at protein level;
KW Lipid transport; Phosphoprotein; Reference proteome; Transport.
FT CHAIN 1..3993
FT /note="Intermembrane lipid transfer protein VPS13B"
FT /id="PRO_0000065881"
FT DOMAIN 2..102
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000255"
FT DOMAIN 2604..2683
FT /note="SHR-BD"
FT /evidence="ECO:0000255"
FT REGION 100..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1262..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1616..1637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1735..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2048..2067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1268..1303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1752..1770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 413
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z7G8"
FT MOD_RES 998
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z7G8"
FT MOD_RES 1001
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z7G8"
FT MOD_RES 1032
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z7G8"
FT MOD_RES 1789
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z7G8"
FT CONFLICT 2402
FT /note="V -> I (in Ref. 2; BAC65584)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3993 AA; 444015 MW; 91DF61575D20A990 CRC64;
MLESYVTPIL MSYVNRYIKN LKPSDLQLSL WGGDVVLSKL ELKLDVLEQE LKLPFTFLSG
HIHELRIHVP WTKLGSEPVV ITINTMECIL KLKDGIQDDH ESCGSNSTNR STAENTKSSI
KPRRIQQAAP ADPDLPPGYV QSLIRRVVNN VNIVINNLIL KYVEDDIVLS VNITSAECYT
VGELWDRAFM DISATDLVLR KAINFSDCTV CLDKRNASGK IEFYQDPLLY KCSFRTRLHF
TYDNLNSKMP SVIKIHTLVE SLKLSITDQQ LPMFIRIMQL GIALYYGEIG NFKDGETEDP
PCLSKDTLAN LTGTEEESRI DMQYPAPYKG QELYSQDYEE PQGWVSWAWS FVPAIVSYDD
GEEDDLGTDP ASIMHQQKAQ TLKDPIVSVG FYCTKATVTF KLTEMQAENS YYSPQKVKSK
EVLCWEQEGT TIEALMMGEP FFDCQIGFVG CRAMCLKGIL GVKDFEEHMN RSETEACFFI
CGENLSTKGL TYLTNSLFDY RSPENNGTRA EFILDAAHHK ETHTDIAGIQ RFGAFYMDYL
YTVEHSSGKG PTSQQDFPSG KNEDLGIVQE KSTKSLVIGP LDCRLDSSAV HRVLKMIVCA
LEHEYEPYSR LKPESKDEKE TVLDPEEVSS LEEYIPTRHT SVTLLKCTCT VFMAEFNLLD
CLLPVIMGGK NSSNVTNATN FQSLRPLPSI QILVDKINLE HSVPMYAEQL VHVVSSLNQP
SDNLLHYCYV HCYLKVFGFQ AGLTCLDHSG SYCLPAPIIP SFSTALYGKL LKLPALWTKR
SQTVVTEGIF ELPNLTIQAT RAQTLLLQAI YQSWSHIGNV SSSTVNEALM NEVFPMTGVK
SKNPLPTLEG SIQNVELKYC STSLVKCASG TLGSIKICAK APGDSGKEKL IPLLQGPSDT
RDLHSSKWLN ESRKPESLLA PDLIAFTIQV PQYMDYCHHS GAVFLCSVQG LAVNIDPILY
TWVIYQPQKR ANRHAQQQPV VAVPLVTSVN RRKEDELSIG SAPLGKQQSY QASEYASSPI
KTKTVTESRP VSVPVKAVLR VHEECRSPED KMKEFIAILW NAVKSLTLQL DVQSCCVFIP
NDNLPSPSTI VSGDIPGTVR SWYHGQTSIP GTLVLCLPQI KIISAGHKYM EPLQEIPFVI
PRPILEEGDA FPWTISLHHF SIYTLLGKQV TLSLVEPMGC TSTLAVTSQK LLPVGPDGRH
SFVVCLHVDL ESLEIKCSNP QVQLIYELAD TMSKVWSKIQ KRGNLSPSSV YPETVAGPIP
GSPVWSSVGT APPDTSTCSP SADIGTTTEG DSVQAGDDSP FSDSVTLEQT TSNIGGSSGR
VSLWMQWVLP KATVKLFAPD LEKKGTEVCM VSELEDLSAS IDVQDVYTKV KCKVESFSID
HYQSRPGEGW QSGHFEGVFL QCKEKPVTTT KLLDGAHQQH GFLSLTYTKA VTKNVRHKLT
SRNERRSFYK LSEGLMDGSP HFLHEILLSA QAFDIVVCFP LLNAIASVFH TKLPKTQREK
RKSSGQPMRT HTLTSRNLPL IYINTSVIRI FVPQTEETQS TVAVNQAAKE DTMVLKVGSI
AMAPQADNPL GRSVLRKDIY QKALNLGILR DPGSEIEDRQ YQIDLQSINI GTAQWDQLKP
EKGSGSGGVP TESERNSQNP ALEWNMASSI QRHQERRAIL TPILTDFSVR ITGAPAIIFT
KIISQENLHM EEILVCGHSL EVNITTNLDF FLSVAQVQLL HQLIVANMTG LEPSTKATEI
SKQEQKKVDT FDGGTAETSS RYSGAQDSGI GSDSVKIRIV QIEQYSGASQ HRIARPSHQS
SIVKNLNFIP FDIFITASRI SLMTYSSVAL PKFKLPEQKE DGKTGRTFLN LAEVDSDVAK
PNQACVSMVT AEDPLSSSTS FSSGKKVRVL SLESLHASTR SSARQALGVT VVRQPGRRGT
GDLELDLFLH LIVSQPSLLL SCHHRKQRVE VSIFDAMLKG VPSDYTCTDP GKTLPEASDY
NIVWLQTVPG ETDSKSGIPP SLVTLHIKDF LNGPADIYLD VSKPLKANLS FTKLDQINHF
LKKIKKAHSS AHSKETSTPS DSILNMDEPP VPKCYRGKLS KTKVHCDEAQ KTSFQENIWR
AISCFQKVSV HTTQIVVSME TVPHPHKPCV LASLSNLNGS LTVKAAQKVP GASLGSSFLL
SIHDVLLKTS LKERSRILIG PFSATVNLEA KWCKHSGNPG PQQSIPKISM DLRGGLLQVF
WGQEHLNCLA LLHELFNGYL QEGKSEMPVP ESAPQMPSPV EKTQAFKTEQ SSDDLRTGIF
QYVQDAESLK LPGVYEVLFY NETEESPGMM LWRYPEPRVL TLVRITPVPF NTTEDPDIST
ADLGDVLQVP CGLEYWDELQ KVFVAFQEFS LSESKVCELQ LPDINLVHDQ KKLVSSDLWR
IVLNNNQNTT DDQSSASESG SQSTCEPLVT PTALAACTRV DSCFTPWFVP SLCMSFQFAH
LEFRLCHHLD QLGTASPQYL QPFISDKNVP SELEYMIISF REPNLHLRQW NSGPVCQEIK
FSSQMDCKLL ECRNVTMQTV VKPFGICGQM ALSSDGVQKL LDSTVIVDSV LVNFGQHVVH
SLNTAIQAWQ QNKCPEVEEL VFSHFVICND TQETLRFGQV DTDENILLAS LHSHQYSWRS
HKSPQLLHIC IEGWGNWRWS EPFTVDHAGT FIRTIQYKGR TASLIIKVRA LSGVQKQIII
CGRQIICSYL SQSIELKVVQ HYIGQDGQAV VREHFDCLTA KQKLPSYILE NNELTELCVK
AKGDEDWSRD VCLEPKASEY STVIQVPTSN SSIIYVWCTV LTLEPNSQVQ QRMIVFSPLF
IMRSHLPDPI IIHLEKRSLG LSETQIIPGR GQENPLQNVE PDLVHHLTFQ AREEYDPSDC
AVPISTALIK QIATKIQPGG TVNEMLDEFY GPEKSQEPTW PYSNKDSDRN EQLSQWDSPM
RVKLSIWKPY VRTLLIELLP WALLINQSKW DLWLFEGEKI VLQVPAGKII IPPNFQEAFQ
IGIYWENTNT VHKTLAIKLV HNLTSPKWKD GGNGEVVTLD EEAFVDAEIR LGAFPGHQKL
CQFCISSMVQ HGIQVIQIED KTTVINNTPY QIVYKPHLAI SNSYSGKEHC HVPDSATFSI
CPGGEHPAVR SSSLPCWDVT PAVGSSELDT ATLQKQILLG FSPVPGADSA QCWSLPAIIG
GEFPRQSVAV PFGTGRENGF CTRAIALTYQ EHLGVTYITL SEDPSPRVVF HNRCPVPMLM
KENIRDIPKF DVYCKKIPPE SSVHHELYHQ IISYPDCKTK DLLPSLFLRI DSMEEMTAEW
SDPVDINSQG TQVVFLTGFG YVYVDIAQQC GTVFIILAPE GKAGPIFTST SRALERMVTF
RMFITQLSLA VSDDLTHQAP SELLRLTLDN VFLHVSPVPA LLPGEEPPSS FFQLYGVEVY
CGDLQLDNQL YNKSNFHFAV LVCQGERTDP AQYSRVQSLL VSSKALEEYK ENCFIKLCLT
VSEGKDILLD VSEFTFELKP ARLYVEDTFV YYIKTLFDTY LPPSRMSGHH AQLFTGQQVL
PVQVTQHAKA LVNAVKLRKL LIQPVNLLIS IHASLKLYIA SDHTPLSFSV FERGPVFTTA
RQLVHALAMH YAAGALFRAG WVVGSLEILG SPASLVRSIG NGISDFFRLP YEGLTRGPGA
FVSGVSRGTT SFVKHISKGA LTSITNLATS LARNMGRLSL DEEHYNRQEE WRRQLPESLG
EGLRQGLSRL GISLLGAIAG IVDQPMQNFQ KTSETQASAG HKAKGVISGV GKGIMGVFTK
PIGGAAELVS QTGYGILHGA GLSQLPKQRC QPTHLYADQA PNSHVKYVWK MLQSLGRPEV
HMALDVVLVR GSGQEHEGCL LLTSEVLFVV SISEDTQQQA FPITEISCAQ DTKQNNLLTV
QLKQPRVASD VEIDGARERL SEQQFKRLVD YIAKTSCHLA PSCSSMQTCS VVAVEPPPAT
VKTYHYLVDP HFAQVFISKF TMVKNKALRK GFS
