VP13B_SCHPO
ID VP13B_SCHPO Reviewed; 3131 AA.
AC O42926; P78843;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Intermembrane lipid transfer protein vps1302 {ECO:0000305};
DE AltName: Full=Vacuolar protein sorting-associated protein 13b;
GN Name=vps1302 {ECO:0000312|PomBase:SPBC16C6.02c};
GN Synonyms=vps13b {ECO:0000312|PomBase:SPBC16C6.02c};
GN ORFNames=SPBC16C6.02c {ECO:0000312|PomBase:SPBC16C6.02c};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2999-3131.
RC STRAIN=PR745;
RX PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT "Identification of open reading frames in Schizosaccharomyces pombe
RT cDNAs.";
RL DNA Res. 4:363-369(1997).
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites (By similarity). May play a role in
CC mitochondrial lipid homeostasis, Golgi vesicle transport,
CC reticulophagy, actin cytoskeleton organization and formation of the
CC forespore membrane (By similarity). {ECO:0000250|UniProtKB:Q07878}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS13 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA16910.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CU329671; CAA16910.2; ALT_SEQ; Genomic_DNA.
DR EMBL; D89192; BAA13854.1; -; mRNA.
DR PIR; T39553; T39553.
DR PIR; T42752; T42752.
DR RefSeq; NP_596800.2; NM_001023821.2.
DR STRING; 4896.SPBC16C6.02c.1; -.
DR iPTMnet; O42926; -.
DR SwissPalm; O42926; -.
DR MaxQB; O42926; -.
DR PaxDb; O42926; -.
DR PRIDE; O42926; -.
DR GeneID; 2540138; -.
DR KEGG; spo:SPBC16C6.02c; -.
DR PomBase; SPBC16C6.02c; vps1302.
DR eggNOG; KOG1809; Eukaryota.
DR HOGENOM; CLU_000135_0_0_1; -.
DR InParanoid; O42926; -.
DR PhylomeDB; O42926; -.
DR PRO; PR:O42926; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005768; C:endosome; ISO:PomBase.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0120013; F:lipid transfer activity; TAS:PomBase.
DR GO; GO:0005543; F:phospholipid binding; ISS:UniProtKB.
DR GO; GO:0120014; F:phospholipid transfer activity; ISS:UniProtKB.
DR GO; GO:0120009; P:intermembrane lipid transfer; ISS:UniProtKB.
DR GO; GO:0045324; P:late endosome to vacuole transport; ISO:PomBase.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_C.
DR InterPro; IPR017148; VPS13_fungi.
DR InterPro; IPR031642; VPS13_mid_rpt.
DR InterPro; IPR031646; VPS13_N2.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166; PTHR16166; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF06650; SHR-BD; 1.
DR Pfam; PF16908; VPS13; 1.
DR Pfam; PF16909; VPS13_C; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR PIRSF; PIRSF037235; VPS13_fungi; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Lipid transport; Reference proteome; Transport.
FT CHAIN 1..3131
FT /note="Intermembrane lipid transfer protein vps1302"
FT /id="PRO_0000065879"
FT DOMAIN 2..115
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000255"
FT DOMAIN 2085..2363
FT /note="SHR-BD"
FT /evidence="ECO:0000255"
FT REGION 774..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..799
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 3002
FT /note="T -> P (in Ref. 2; BAA13854)"
FT /evidence="ECO:0000305"
FT CONFLICT 3076
FT /note="H -> T (in Ref. 2; BAA13854)"
FT /evidence="ECO:0000305"
FT CONFLICT 3115
FT /note="K -> E (in Ref. 2; BAA13854)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3131 AA; 354025 MW; BBD22BE7F668EEF4 CRC64;
MLEGLLANFL NRLLGEYIEN FDATQLKVAV WNGDVTLRNL QLKRSAFRKL ELPISVQYGL
VEELTLKIPW SSLKNKPVEI YIVGIRALAS MEENVKSQSE VDPHQVLESK RRQMQLWEAS
QIGKAETAYD PKTQTFTESL ITRMIDNIQI NIRDIHIRFE HLPVSNVVPG GYSFGLLLSE
FSIESCNEEW TSTFVETESQ TIYKLCSLRG FGIYSDETAE CIDKTDINEL MNTFQALITD
FQSREKDYII APVTGMAKVT INKLPTPEIP RFLSQISFRG FDVSLNDSQI SCGMSLAHEL
QDVMSKLAFR KRIVGNVSLD TPLDYLRFIF QKTLHDIQQK HYARSWPAIK AFCEKRRNYI
KLYKKKFLAV QLSADESKEL DVLELNLDIS QLKLFRSLAY QEIKNEGFEP QPPKQQGWGS
WMWNSFRGAS DENGEVTDDQ RKTVIDAIGL NDSIIESAHV GDLQSNTSLF DVRLEVPSGK
FSLLKYPKKE NVISLELLNF FSQFKCNKKD YSFVANLGSL KMYNDDRNFL YPRETSNKEI
ETTSPSIFTL SFERSSSDDN DTDTLGINLR ALEFFYDPNL LLRVKGFQSS LFANDNGRKL
VRLANDAVTD FTSQTVQNLQ EYLNEKRKLN VNFQFQTPLL IFPEDCNNPE SFSLFVDAGF
ISITSQNVET NDKESNSESE TLYHLIYDRY RVSLESARLL LGPLNELKNE SNKINEEYYL
MNELNTEIFI QAQRVPTPQY PRIKVEGNMP CLSFILSDAQ FRILNNLAST MLKDGKASDD
DDNGDWRPES SESLDSHESE YKLNNTPSEQ SVKVSHFFEF NMKLGEVTLI LCREDSQTKR
NSMVSVNFAK LLLSFNQFED NSHLRMSINS FHINDMLSKS SRDNNRQLMR CYAPDSVDAE
NTPVIVEIKS VKAGENQSET NTTVDFLCAN GDFYLAKFSI LTLIEFLPSF APPPSNDKQS
TPQVSNSAAG KMELNFKIHK IGLRLLENYE SKPICIDLLA LDLSVNSTKG ISEVESRVDK
IQVMAWDHEK DEIVTLIDSK QDSLFDLKCK MQEGWFIHSP NPSTDVNIKM GSFTMLCHKQ
PIEEILNYAS NFGHYKAIVQ SVKYLAETGT HQVQQGTNVN INLYISNPIF QIPLTLENGS
SAMVEILPGS FSLKTPSWLP NLTLNLESKS TTLRTIYYSK DFDEKGNQIT VLDDLNISLD
GSIVQAVDSA ITNYAIDLHC GISELLIHLS QAQYLILLKL ASNLPEMLSI ANAFSANVDA
PSVMTLLSEE LYSIDTVNDA ISNLSQNSSF DMKFGLHFPK ISLNLYDGTF ITPENSLSPL
SNFTLNEIRA EGSYDLKTGA SALIKMASLA IEDVRSEKSR YFSNVIIPST DTESQLQVSF
QYKPDTSSIL LEGDIFKSMY VLSLDHLLSI YYWFGQPLME KKLESPDDVQ SLQAESSVST
PAVTAASEKS ISLSVRFDIR NTSLVFVADA SKSTSQAIVL RTDQISLVKQ LSYSLTVQKM
GMFVTRMDKL DDGIQILDDF DIGFGLVQDC SENKSFSATL DLDRLLFRIS VYDLLLLQSI
AQASVSVISS YKDKSSSISE NMNSGDYGQQ ILNASNIAAV QQKAEQTATT LLTVLGHDSL
ISEEFTINSA GIQLILISDA HCLPVFDFTI ENFNVLVKDW STNLSATTSL TLHCNAFNFA
KSHWEPVIEP WTFSTTAIMK DGMHEVNINS DDIAQISLTP MMVTDVHRLI KFYLTNQENN
IEKRPEGYPY VILNQTGYNL SIQYGNLNSS EMQSLSLPSG KCVPCRFESK EVLTSRMSSK
VQDVATKVRV SFDSTWYPVD EVSVHQEGSF LYELKPRIDQ RTFLLVTVVL LESNIKQIIL
SSPYSIVNRT KEVIEVVCND RSGHRQSSVI KIDPNETGYV PLDLACLYPL RIRPVSKLGF
LWSNQIVDWH SLNKSPLQYL TCESTSTSWK HNLLVFARNL MDGSLQNDYP FLQLNILPTL
QIENLLPYEI NLRIIERSSG NDWRSSLSPG DSLPILHTDS KSFLLMGINV PDLDLQPVDL
PIIYTPISSG QDVQTSALLT ASDKQDVVKL ILKYEKLPGT NYVSKVMIYP PYVIFNHTDL
SIQVTSSSPN SIRYTIPSGS YSNDIKPYFY SFDESGRKNR AMISIDNGTS WSADIGFDTL
GSSSQVEVRK TNESDVCLLG MSISESSGKF CLTKSVTFTP RFVFKNHLDC TVSLREFGSS
KVLHLPSNEL IPMMYFSNPQ EIALLLSLPS SNNHWTSPFL AQNVGIVHLK AFEFDDDDNN
MSTTLLRLCV TLEDATFFVT ITKEDKAWPF RLKNCTSREI CYEQKRPDPE SVDSRFLQGS
RSMKYALNPG EEANYSWDFP ILKSKLLQVE VGKAIHDLDI SSVGQLEPWH PTELDQKIRI
HPEVKVDSLT SLVTFNEIDL SKPKLPSRTN SNVKGSIVEQ KFKLVLQLKG FGISLIDKKY
EEFAYATLKN FTFRFDDSKD LNTFGMSLGW LQIDNQMLDS VYPIALFPTM ITQEVKQDDP
QLLQLRFSVL KDSSFNILYI KYASLLLQEL SLEVEDRLVL TLLQLLYPSS DVSKDSASLS
KNAFADKFEI PDLDADVYRS NVFFETLHLQ PTRLNISFET SYESDQPAVK SSNPTLDFMT
GILISTLGNI HDAPVQLNSI LLENARGTLS EMANRVASHY KQQVGYQIYK IAGRADFLGN
PVGLFNNVAS GVFDMFYEPY QGFLLQDSQS FGDSFARGTS SFMRKTIYGV SDSVSKITGT
ISKGLSTMTM DPKYQNSRRR FRSRNRPKEA VYGVTAGANS FYDSMSSGFK GLKKPFTDPK
NNSAGKFLKG FGKGMLGLAT KPAIGLLDMT SNVSEGIRNS TDVRTNPEID KVRVPRYVEF
GGLIVPFKPY ESLGKYMLSC LDDGKYAFDE YLYHAEIQNV DILYISTKHF IITGSNYIVK
IAVPVKQISG LRVSEHDLNS SCLFTFAVFW QRCESLFDCE YLSTPNLELF VKEKKKPIMS
ITMSDSSAYG EELMRERFEH LLKAYEKMAL MVAEQEEFNA KIEDMALKLL SEKYDNEAYQ
AELFYRLSNC VEKVLHNKIS ITDLKTEYEE ILEQTLKKEC KAYERSCIEN VKLKKRTEQA
TAYYASSSSE P
