VP13C_DICDI
ID VP13C_DICDI Reviewed; 3848 AA.
AC Q55FG3; O76737;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Intermembrane lipid transfer protein tipC {ECO:0000250|UniProtKB:Q709C8};
DE AltName: Full=Developmental gene 1038 protein {ECO:0000305};
DE AltName: Full=Putative vacuolar protein sorting-associated protein 13C {ECO:0000305};
GN Name=tipC; Synonyms=DG1038, vps13, vps13C; ORFNames=DDB_G0267422;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RC STRAIN=AX4;
RX PubMed=10402673;
RX DOI=10.1002/(sici)1520-6408(1999)25:1<64::aid-dvg7>3.0.co;2-1;
RA Stege J.T., Laub M.T., Loomis W.F.;
RT "tip genes act in parallel pathways of early Dictyostelium development.";
RL Dev. Genet. 25:64-77(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP DISRUPTION PHENOTYPE.
RX PubMed=17659086; DOI=10.1186/gb-2007-8-7-r144;
RA Sawai S., Guan X.-J., Kuspa A., Cox E.C.;
RT "High-throughput analysis of spatio-temporal dynamics in Dictyostelium.";
RL Genome Biol. 8:R144.1-R144.15(2007).
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites. {ECO:0000250|UniProtKB:Q07878}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Arrests development at mound stage, increases
CC aggregate size and produdes multiple tips.
CC {ECO:0000269|PubMed:10402673, ECO:0000269|PubMed:17659086}.
CC -!- SIMILARITY: Belongs to the VPS13 family. {ECO:0000305}.
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DR EMBL; AF079445; AAC31916.1; -; Genomic_DNA.
DR EMBL; AAFI02000003; EAL73163.1; -; Genomic_DNA.
DR RefSeq; XP_647570.1; XM_642478.1.
DR STRING; 44689.DDB0191112; -.
DR PaxDb; Q55FG3; -.
DR PRIDE; Q55FG3; -.
DR EnsemblProtists; EAL73163; EAL73163; DDB_G0267422.
DR GeneID; 8616380; -.
DR KEGG; ddi:DDB_G0267422; -.
DR dictyBase; DDB_G0267422; tipC.
DR eggNOG; KOG1809; Eukaryota.
DR HOGENOM; CLU_223857_0_0_1; -.
DR InParanoid; Q55FG3; -.
DR OMA; AKSHWEP; -.
DR PRO; PR:Q55FG3; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IMP:dictyBase.
DR GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0045324; P:late endosome to vacuole transport; ISS:dictyBase.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0016236; P:macroautophagy; IMP:dictyBase.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR InterPro; IPR015412; Autophagy-rel_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_C.
DR InterPro; IPR031642; VPS13_mid_rpt.
DR InterPro; IPR031646; VPS13_N2.
DR PANTHER; PTHR16166; PTHR16166; 1.
DR Pfam; PF09333; ATG_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF16908; VPS13; 1.
DR Pfam; PF16909; VPS13_C; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
PE 3: Inferred from homology;
KW Lipid transport; Membrane; Reference proteome; Transport.
FT CHAIN 1..3848
FT /note="Intermembrane lipid transfer protein tipC"
FT /id="PRO_0000365725"
FT DOMAIN 4..112
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000255"
FT REGION 243..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1907..1926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2024..2047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2209..2290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2330..2353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2509..2541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3209..3228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3310..3342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1213
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2210..2287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2331..2353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 10
FT /note="L -> H (in Ref. 1; AAC31916)"
FT /evidence="ECO:0000305"
FT CONFLICT 1864
FT /note="S -> P (in Ref. 1; AAC31916)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3848 AA; 440005 MW; 94F68AA1D47E7127 CRC64;
MVSHIAASVL TKYLGDYVDD LNKDNIKLSF LSGEAVLQDL KIKKTVLQSF LPNVIVKQAI
IKKLSLHVPW KDLKGKPAII KIEGIYVLAE TSVEFDEQYY KKKFQDEKQA KLHIQEVLRL
NKQQLKNPHQ STTTTTTTSD ESNTFGSKLL QTVVDNLQLY IDSVHIRFED SVNRRSFSFG
VTLNSLVAES TDQTWNPTFI KNESTIIHKL INLNQLSIYW NSNSPKLKYT NIDDLSQKLK
SMIKKEDSGK QQQQQQQQQG EEQDDEIEED YFLSTESRKQ QYIIDPISAK LKVVINKSII
PSEVIPKYNL NFEFDKTDIS LSDYQYKDIT GILESFKLFE KSIEFRSARP INTTIKQSPR
KWWNYAIQCV LQKVHQKRYT QSWSYIKEFL SDKRDYIELF KKLKKKTIHQ TEQTRLDSLE
WKLPFDQILF FRNLSFKIIE KEEKLEKERL KLQQQQQQQQ QNLNKISPTT TTTPSTSTGG
GGWLSSWWKP IVNTSVPITA ATTTTTATNT DSTITKLKDI KLSKDDWNEI YDTIGYDEND
DIINSNVASL QQPKQFGKDF SNIIKTVINF RLVQGGLKLK KKRRTIALLQ LNDISLSLKS
KINSSFVFNG NLKGLELIDQ STFNTQFPKL ISPLLKRNSS SIPTKIISQP PIFNITLESH
SLSSTITSST TTATTTQSTS TNSNNNNNIK VNYSLSIQSK PLTIVYYPKF ISTVNDFFFK
KEDDQDVQDM VLEDLEKKAQ ETIESIKAQT RDKLLLAISN KTTFSIDMDL EAPIILVPES
ITNKNTNLLI LDLGKLLINH YPKQQQLQQQ LQQLQQEQGQ EQEQEQKQEQ KQEQEQKDWK
EEFYDEYLFK LINTQVLLAN LKNDWRDIEQ VKKFRMNIAN PLNANFTLKI SKLNNRQLLT
SLKLMASIDL LEFYLSSCQY VNLVNIIQSV TQPIDQQQQL IGSESMYMSA FDYSSVYQSN
IFKQPQQLQP QQKQQSPPLI SSPPLIKKKK SYSKEFIDSY KMFEASFNID KFNIHLRLDN
YDSSGSSSNN DSSNTTTTNH NQLVSHNVAL VYLRCLHGTY VQKLFDTNLE LLIKGMWIED
CFQKPQSIAH GSGGDYLATT TNRFKPNDVN IGGGSNENLI KFKIQQISSD SPFYNNIDKL
LDIELSQINL ILNRKTVAGL IEFSNSVSNL SILKNNQNNN QNNNQNNNQN INESSPTVFI
TSPPPPPPPP LNHQSNNNSQ YDTLSSSTYL IRNSNNKILP PIQQISTTAN NNIKIQTKAT
IKIDLVRILL TRENNNPLIK ASFTGFNCTT DQYNYKTIMN GKLGSLKIYD MTTEGRNYRT
ILTTRERKLN NKTSPTTPSS SGVSTGTTFD IDIDNFDTVS SSSSSSLLSS SSLLISPPGG
EQSSLVYFQF ESRNDNNSQM LKINLSSIRF IFLKRFTEEL RLFLNNVNMM REYLKSSIYS
AATVISQNRS TLFYEIEIQN PYIVIPLSSL SNKIFIVDLG KINIKNQFEK IIPTSTGEID
MILMEPVIIE NIIIEAQNIK LLSGLNSEIK KSENNNNNNN NSNTNQRSYG TMVSDVNVSI
NLKTPLFSEL NLKQYLEQCM KLQSWEKHFT ISQFELNVSE YELKSLIELL DGNLSEFSSE
ILNDANSSFD QQKQQEIEKL KLQQEIEDNN NDNEDEQVNK LLQLIKEQVG YTYCKLGKFS
IMFMKRDGTD IDDRLVLFYV SEAKMDIIKE EMETSMNIEI KSVQMKDFSK ETHPHLRNIL
TPLSLKSVNE KRQQKEQILP QIIIKGSIKP PPIQQSLFQI SIDGMFMIFV PHSWIPVQDS
IMKLSKFATE AWNRYTIKVY GEAPTNDEII QSGLSLFSLS IKDIKISIPG DCTVNSGQGE
NEYSLFIRSS LDIQTTSRGA MGVETITLID ANNIQIYRNQ LVDTNNENIN NNNNNNLTTS
TTTTTTTNKN QSNIKIIAPF KIVFQTTSTL LNSESSLSIN NIVVTFSYQD FKLMMKIINS
IIESNNQNLI QEKMKRNYLK KYRDPNECTS DDELEEQLQQ LENDDYNDDN YNSNGNNNNN
NSNNQLPVKE DSQLQKYLSI SLEKGEFILN DDHKISSPIK LLSIGVDGLK SNIFSFPQKN
QIALSLDANM KAGYFNKNIG IWEPLIENWG FSFTSNNSIE GGWMVNFNSK IPLYINITKI
FIDTSISTYQ IWADDYYSQQ KKDKKNKSND YDNDEIIEDT VEQVNNDLIK PADDQKNNNN
NKNDNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNKNNN DNNNNIKNNN
NNENNNNKNL QEKEEIKYPY YIRNDTGVEL WYWVRSDEIQ KLPVGKEAGF NPKFSSSSSS
SQQQQQQPLS PLLQTQQQIQ LKPEELQQKI ELERKISFQL FGDFQPIAKV PMDSIGTYTL
YPMPEYKNIK LLYEISYRNG AKVLSLHSNF NIRNDTDIPV VVHITAIYNQ IPRSIEILLN
PHVKIPIPVE YTIGRIKYKP YNLGYDYSAE RIDCSNVLQL FKSSKQKQKQ LNNQLQQQSN
NNNNNNNNNN NTNSNNSNLL GNLIGGNNNN NDLNIGKISS KMICKHGVKL PFVFLSSIEK
NSLETKNTIE ISINTAIMIE NVLACDLQYR LYHGKNKKII GSAFFSGVIP MGKKLPVLVY
DSLQDIYMEF QIYDFQWSPL CLIDSMVGLA VTDKVKIEDR LHQPLLISFD NRIQPNGSRF
VTLYCEYWLI NQTGLPLYFR HHIGAQTIDP AGQTPTKQIE TIHESTSMKP TDSRNWYTKE
WNHPSQPFMF AYSDNSIVGG KFSLKIYDSN WSSPFSLISS QSSSNSNIEI SEDRTDEEKE
IKNVIGTITK RQPLKTNYNL SVSILPSNSK FWRTKVVTFS PMYLMVNSTR FRILYQQFDC
DSNTQSIIQD QSLPFQFPSS RHEKLIRIGI LDTSAISNNP YNANDVSNIK WSGYFNPQIL
GQVVLRLRNE TDNSSGGVLN KFKKDSEIST KKRNSNFISN LLTIKNKQLN VDSSNQQQQQ
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQSIN QQTSLNSSSS STITSTNSTV IFEDLRVFIN
VTIRVKSSKS LTTTMIILNE QNPELPPYRI NNKTRFPLWI RQKKTEIWDK VQPKTSIPYA
WDHPILPKKL IIEFPTGLTK TYRLGNLEEN SIVSIKNPNS SGGYDRVDFQ ISIIANGPTR
VLNIKERDLN GDTNNNTISP QLNSIETFGI TNDPNNPNNP NNNPNNNDKL NVKYEFSIDL
SNIGISIINK IPTREEIVYL SIDGLKLEVK QSKLDQYIQF KVDDLQIDDQ RYSTNFPVFL
CQSKKINHSI NQQPNQQSSS PQSTNTTTTT TTNTTTTNNT TQQQKLKPFL QFSATRTLKY
SNIMFFRYFS ILIQEFDINL DEASILNALS FININLNSLN EHFTLHPTIT QEEILETKNA
SNIENHMVYF EMLHINPVKM NLSFISCKSP KETQAILGAR SLAELLIGFK SNSPFLNIER
APIKFNGFIW EHPFLSTRQV IDEISLHFSY QMMSQAHKIF GSFDFIGNPI RLAESLGSGF
KDFFHEPALG LVKSPQDFAA GLSKGTSSLI NNSVFGFADS TSKITGTISK GLVQLSLDDS
YIKERQESNK QKPKGVKEGL EFGFRDFGEG VIKGITGIID EPYKGATQEK SWEGFFKGIG
KGVLGVAVKP TVGVFDLVSK TSEGIKNSTT VAKSLSQIKR RRIPRYFPRE GTLSTYNQFK
SIGSFILYSK IGPPPTHDWY VFHTILNYKD LILIGSNYHL LLIRCANLSI NGNLSDSEII
WKVKFSEIIQ IKNIPSNFGF QLFVNVNGVG QPPITLLIPT LTEEVRNSVV RKITDLILLE
KRFGNNLD
