VP13D_DICDI
ID VP13D_DICDI Reviewed; 4592 AA.
AC Q54LN2;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Intermembrane lipid transfer protein vps13D {ECO:0000250|UniProtKB:Q96RL7};
DE AltName: Full=Putative vacuolar protein sorting-associated protein 13D;
GN Name=vps13D; ORFNames=DDB_G0286545;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites. {ECO:0000250|UniProtKB:Q07878}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
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DR EMBL; AAFI02000088; EAL64174.1; -; Genomic_DNA.
DR RefSeq; XP_637675.1; XM_632583.1.
DR SMR; Q54LN2; -.
DR STRING; 44689.DDB0234205; -.
DR PaxDb; Q54LN2; -.
DR PRIDE; Q54LN2; -.
DR EnsemblProtists; EAL64174; EAL64174; DDB_G0286545.
DR GeneID; 8625668; -.
DR KEGG; ddi:DDB_G0286545; -.
DR dictyBase; DDB_G0286545; vps13D.
DR eggNOG; KOG1796; Eukaryota.
DR eggNOG; KOG1809; Eukaryota.
DR HOGENOM; CLU_223579_0_0_1; -.
DR InParanoid; Q54LN2; -.
DR OMA; SFHPYWI; -.
DR PRO; PR:Q54LN2; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_C.
DR InterPro; IPR031646; VPS13_N2.
DR PANTHER; PTHR16166; PTHR16166; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF16908; VPS13; 1.
DR Pfam; PF16909; VPS13_C; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Protein transport; Reference proteome; Repeat;
KW TPR repeat; Transport.
FT CHAIN 1..4592
FT /note="Intermembrane lipid transfer protein vps13D"
FT /id="PRO_0000365953"
FT DOMAIN 3..102
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000255"
FT REPEAT 2321..2354
FT /note="TPR 1"
FT REPEAT 3789..3822
FT /note="TPR 2"
FT REGION 95..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1655..1717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1855..1886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1971..2001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2025..2056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2245..2270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2456..2489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2862..2882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3006..3035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3106..3129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3356..3384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3560..3580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3630..3679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3872..3897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4105..4135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 437..517
FT /evidence="ECO:0000255"
FT COMPBIAS 114..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1668..1717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2025..2049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2456..2477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3010..3035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4110..4135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4592 AA; 516270 MW; D0742E11F67F7A76 CRC64;
MVFESVVAEV IDRFLGSFLQ EVGKKQLKIG VLNGNVVLKN IEVKPEAFKA FDLPLSIDRG
IVGKLTIKVP WTSLKSESVV VHLQDIYILA SSSSTNVSSN YSSSDDDSSY HSDDDNSSSN
NNNNNNNDSS SSSSNTTSTA SQLYDSSSEK FLKFLKLDKK KPKKENSNGD LKSTNTTTNN
NGINNSNDKN KNNNNIDSQN DIEFDEESLN ELNVEVNGKK KKDGFKEKLI TKIINNLQVV
IEKVHIRIEE RKNNRNIAIG LCLDKLFVQS TDESWNPIFI DTMPTSTTSS NNNNNNNNNN
TTSSSSSSSI LNKLAKLSDL SIYINHDQEP MKNLPTKDLC QALRDSIPTS KNTLSHHMFL
DPLSANLCLK LHQSAGSIQS INKIEIESII EEIGLCLEPQ QYSSLLSILE NISEFVNDIK
EEKTQNNKSA FESILKKNAT IKLNKKDDKK DDKKDDINSS SSSIGSSNSS NNTPTKDKNK
EKEKDKEKEK EKEKKKEKEK LKLEEKKKKK EEKGKSKSKD SKKNKIKGIE FEVEPQQLIT
KSDSSDSLQS LEKPSKELLK QQFYDTIGYV SPTSNSTTTN NSNNNSSSSP NILATSPSNN
SLSPMLISKP IQPKRIEKEL IMNFQIKTIH VKLLSDEPEK ELNKQATLIY GDISNISFSL
YKKADVMNLD SLIKSIKLSG LWVQNEQFPD MISSSTISEN WLSFQMKMSP ILDSSSGVGV
GVGGGGSGTT SPLQTIITTN GNGSGSKKKP QSTPKNITIL IDVKPMFFVL NSAAILRYLQ
LITPNHTIDL SGFSSGKKRP LSRNKVTLSI IAQSPTVIIP ISSAENYNNQ SSSSSSSSQP
PPPKPTEETS TTNKPKKQQG ISFSENTVAI LDLGKISLEM LPSSPIGVND GNFSPSLPIP
SSSSNVEYQN FQISTMNIKS ILTKPPTLTG STTTLKFGKH HPSFKEDNKI ETYCNQRTEM
DKILFETSLI VHMKKRKSDQ PDYENPKVIM NVNFPFVRFY FSPFSFYQIR LFVFQLMSEI
QRVEEAFISS FQFKIRSNST TSPTFNSLNN KPSTLQNNHI DIENGNSSNN NNTDSPSKSK
RQWLSTSNSN LSTMVNNLTE STGIGIGKEN EIIRKREIVF SSHVVFDDIN IIVTNLFNLS
TIDVEPILHI KSDQLVSNLK VEKSNQRDTT VIGDYAFNDC NIYKCTNENQ RGGTNGHPSY
TDDDIVISSN FNKFKSPKYF KNKRKEENEQ NEGNTEDDEQ EEEEQEKKPI IYGTIFHNKQ
LVPTYEKLSD IKINLSTSYC NLIPQITGNI IEIIQMIVVV NRKVTQSVQR QLEEQRMRRP
PSRFTVNKVL IYISVKGIKS ILMLPKLINT TTNTVATQQN NQQYKEEIIS RFDMKEVDLE
ITKLPNRLIL DFFVDGFELY DLVNDFNTNL YNKVLSNYDD SNLLLTFKYE RISKIALPLV
LLDADINRFQ ISLLPNFLNV LKDFILDLFQ FIPGLIKQQK KTNKELTTTT TINDGSNMEK
YKKKKGIKIN ARMEAPLLII PENQLSRNQF IIDLGLLKIN NEFISNQTLS LFHFNLSNVN
LKTIQFNNNR FKENLVLNNL RLNVEMTSIL VWKDNQNGIG VLPPPRLVLD VNLCDVVFKI
NQNDIMFLMD RVSNLMLIIN STKSEFLNLK IKQEQQQEQE QQQDEELQKS INSKPPSPKL
SLMSPLRKST TSPFKKFIPS SQQQQQQQQQ QQQQQSNSNL NRLVNKLPNQ QINQVEEILP
IEEAPINKLN YGGSNGRMKL KLNLKIDSVR FYIEEIGSLF YIKDTKFKSD IGFDGYKQSI
ISIGKIYLFF NQLHQLSFTI PIDKIIQDPN QYEQILSLKD NSVINTLEVN FSTLSNNNND
NNNDNNNSNN SNNNNNTSNG SGNSLFKRMP IQSKENIHPF DSELNLTLRQ FQITVSLNFI
SSILEFATPV IQKVLEFKKN KTATSTPNNN EINSLSNSSI ISDMTPLSLS TSSLDNTSIS
TTTTTTTTTT TTTTTTTTTT STAKIPTISI GSNRRLKKQN SIVMPLINDN SNKSPTSKSS
SSKSSSSKSS KKEQQQEKKS IKVKLVINVE SPQIVLMLNE DDAILIDLGK IHIENLFYFK
TIKGIDLNYE SMEIQLSNLF VEIFQSSSYV GSSFEEFNQN LPDGCGDDSY RNKCHLLEDV
SLVVNIDIVD DFQSYSKICS TSNHYNNNNA PLPIQKVNIH CKSVSFNISH QGYQLLLNIL
INYMNCYKNS LEPILLLKKN FNNNNNNNNN NNNNNNNNNN NNNNNTNIIN NSSKKKKKQI
LIDENGKEID IKTEITVQLS ELRFLMLLNH GMDKVRDQLA TLQINDLGAN IISIGNKSTS
IKCFLRSIRL SDSRVDSGSK FIDLFCSKNI TTFQGPLKDS LTNINISGSF NNSSNQEEPL
ITASIDIDKQ LNKLTLDVKI EKPRLHISPT IVFMMVGFFL EPYSKVKLEI KQLFSKTNNN
NNNNNNNYNN TNSNNNNNQE EEEKDSISTK KKKIISLKTN IKKLKILLVE NPNSEVSNLV
IVKMSIDASF DETMNGSSRI IGGSIKNFQM FSFRHSIANV SSSRAASLID PVTFDFGCNL
LLIKSTCPSI EKSNLLIDVN ANIDQFNLFL SYHDILLIAL IIGQLKKEFP KLSKSSKKST
TTTTTLTQKK LKNEKMINNV LTVKFNSPQF GLTLVNDYMD QNLPLIDLSF YRLDLLIQGT
IGDEIKVTVD SKIVMDYFNI NKMAFEPLIE NWDIQLQMIK LNNQNSPNKP ATSIQLSSNQ
FLNINASYGF AHSLLSTYHS IQYDLSTTLP IIMGLFKTKP EFSTFQLSSS PSLSSTQQPT
RVFSPPTIST NLVGGGGSGG FKKSNSSSPL IRSSTIDSLN LAVSTSNNPN GSGYNNSNNN
NGGGLSPDII LPISSTNRIR SGSLSQNPLG SVSTLVTSPN LTSNRLGFNT SPLLSQQQLK
QQQQQQQLFN NSTLLRPIIQ PLPATVRSSP LLQTISIRKL TSSFHPYWII NKTGVNLEYT
VRVLSGEQKG KKKSTSTSTS PTLSSQPSSS SSSSSQYTHA SFFLENEQKQ PISIENSKSL
LTAKKTRDFR GFKDESLDQG PHITIKLSNH NKNVKNFVNN SVVNSNSSGY NSSSPSPSSS
SSPSSSSSNP IPIGRVGYRL IQVGGKKLIF EVGWNEDGSK VITVRSNVLL KNTTTMNLEV
KLINNQINTS NGGSLSSNNN NTPKEIKKIL FPNEELPVPL QYINSGKYLS ILPIGDSGEE
FKHSNPFNDL IALDDNDIHS LYKILTCPKI IPKSPQIHMK NNNNSNGNNN NITPPTYNNV
KLILLNSNYE KCVINSTDNS SVNDEINTEQ TLANLLPNEI NLRNDKSKLL RSTISKLPTS
PQTSSSSSPP PATTTTSTTT KRTTINSTMS SFNNIYSQNI IKILSPLVIE NLLPCKIELT
LYEGDIPLES STLESCQSVP FYTQDPRSSL YVKISGIPGF VDQKHLIVDC DRNNGSNGNK
PIIKSKIKLE DPNKILKPLN IMISNREDQV EGVRKLALYS VYWIINKTGL PMIFEKPNFI
PMLFADKESK IPQMIAKSKN SLKIEQGRKS KKQQQQHRHN HCTIDTMILY SSDLLYIKVP
NSDWSNVFSL ETVGTDGIIH CFSNTNSNNS TNHHQDPFYS STFNNSSNDN INNGNSNNNT
SNSLSPPSSS SSINLSKLKS NSDNREYNFR ASISMGKNKL QRTKMVTINF QYIFINKSSR
RMLYRQIGQS YRIESIEPGE SKPFHWPNRH GEKLIQIKFD DDYYDWSGSF TIDDLAELTV
KQRSLNLMEV PKPYLGRVDI KDNDTHTSIH FYDQDTEYSP FRIENQIPRS IKFYQIGTSI
IDILPPYQSI DYIWDELLGT KILRLEISST TTTTTTTTTN STNDINNDNN NNNNQYIENH
STFESSYSSS SVILDCNIMK IKNFKPIKIG TNTIYSFMKV DGPTRVLVLS YDQPKDDSSS
ELSQTVENCK LDLQLSLPRI GVSLIDHNSK ELIYLSLNDI SLSFSLSNIF SRFELIVTNM
QIDNQLMNTD YPVLFYHTNN SNNEEQDPKP FLHFSFIKNE EKKGLKYFEL LSLLIQEVNL
MLDDSILASI IETITKIKQL DKNFKKHKKN QQLQQNPQQQ QPQQQNNEIQ NNPINSPFIL
NDEKSKIQLL NDIEPISSDP LLLPTSNSAI SSNNNNNNNN LTKKKKKKSM IYIKLLLLNP
IKVILSFSFV RDGFVGHSNS DFVGILLEVV GVSFGLDRTP LCLNALILEH PFLSERLFAS
RIKSHYTMQS LNQLYKVIGS SDNIGNPVGL FNHIGTGVKD FFYEPALGLI TSPKDFGKGL
AKGSISLVKN SVYGLFNTLS KLSNTVGKGV AILSFDDQYL RNRQRSRQKK AKHLGEGVVY
GFKSLGKGVI DGVTGVVTKP IEGAIKGSIE GFAKGMAQGV VGVAVKPVVG VFDLVTMTTE
GIRNTTNLFK DTTRMRPPRC FGTDNLLVEY NFEQSEGHYI LETTFKGRFK NSDTYIIHFN
NGGVKNYITL ITNLRILLVK QIKNSYSFRW SSTFENIKSC EITPDGLLLH FEHLQRIKSV
DYRSQHCIHI TDPDQLSQLY LIIKEQILKI KK
