VP13E_DICDI
ID VP13E_DICDI Reviewed; 4241 AA.
AC Q55EI3;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Intermembrane lipid transfer protein vps13E {ECO:0000305};
DE AltName: Full=Vacuolar protein sorting-associated protein 13E;
GN Name=vps13E; ORFNames=DDB_G0268886;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites. {ECO:0000250|UniProtKB:Q07878}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the VPS13 family. {ECO:0000305}.
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DR EMBL; AAFI02000004; EAL73032.1; -; Genomic_DNA.
DR RefSeq; XP_647037.1; XM_641945.1.
DR STRING; 44689.DDB0234203; -.
DR PaxDb; Q55EI3; -.
DR EnsemblProtists; EAL73032; EAL73032; DDB_G0268886.
DR GeneID; 8616732; -.
DR KEGG; ddi:DDB_G0268886; -.
DR dictyBase; DDB_G0268886; vps13E.
DR eggNOG; KOG1809; Eukaryota.
DR HOGENOM; CLU_223861_0_0_1; -.
DR InParanoid; Q55EI3; -.
DR OMA; LMDIQYR; -.
DR PRO; PR:Q55EI3; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_C.
DR InterPro; IPR031642; VPS13_mid_rpt.
DR InterPro; IPR031646; VPS13_N2.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166; PTHR16166; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF06650; SHR-BD; 1.
DR Pfam; PF16908; VPS13; 2.
DR Pfam; PF16909; VPS13_C; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
PE 3: Inferred from homology;
KW Lipid transport; Membrane; Reference proteome; Transport.
FT CHAIN 1..4241
FT /note="Intermembrane lipid transfer protein vps13E"
FT /id="PRO_0000365727"
FT DOMAIN 5..97
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000255"
FT DOMAIN 2825..3134
FT /note="SHR-BD"
FT /evidence="ECO:0000255"
FT REGION 120..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1534..1571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2148..2192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2217..2282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3973..4000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4059..4094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4109..4140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1354..1369
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2217..2233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2242..2259
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2263..2282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4078..4094
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4241 AA; 485001 MW; 4382557191CAB1A9 CRC64;
MVSKILPGLL KKILGNYIEG LDTLSIPWWK GQIVLENLKF KKELFSSNEL PFDLLSGVVK
RVVITIPILH FLKDPIVVNI DGVFLLFGPK DIINTFSNYG NDKSNKKDIV IDDNDGGISI
DSNSNNNNKK NAPSSSSSND DFFKKPNLTK EELKKIQIQI DKEQSKESND GYSADSESFK
FRMIKKLLKC IRIQLNNLHI CYQDDSTSPG EIFSVGITME SFTFQTTDSQ WVPLSKNTST
HQQQQPTFNP YVGSQQQQQQ QPQQNTEINY ENDSEHNPFM NNKNSDEGIS SSSSSSSFNN
NNLNIPTLNL NDNYMDSEAY TTNTQPTPKS EQYQQQQQQQ QPLGQIVDQI ITYKLASIFN
FSIYWDSQFG KTRMVTPEDM DVLLMHSIPR QKAKINHKYI LQPISGFLKI CLTEDSIESV
NKEGVFNSIA NNFNVSIGLK QIDLQLMDIQ YRDMLNLLSF YQDWRRVLRY HKFRPHCRVK
GNARIWWHFA FRSIISDFRS KKTEMTWKEI EDSKRVRECY IKLYTEKFIK GKLGRLDQNL
IDEIEKKVTY EDIVLFRTIA EKDLKVTKRK DLDQFTESSG WWLGGWLGFQ HHHQNNNQDK
ITLTNEQLTF LERYLKVNLK VLAGKPHSSV SLIFFLNVKR LSISILDWQE NHTVVPLANI
DITEVNLQME QSHNTKLKFS AESLDIFDRC SPNTKFENII LEKSRFNSSN INPDNSANSI
GSFILDRQIS NSEFLNGVYT GVNGTNNNNN KKFIDISIVL NPPEDTTDYF IYFKLEPFYF
INSKPFVDTM IPFFTHANQE ALDRLKYSFI KKIKILQEYL INELKHLVRN QKVADIKLDI
AIPGLVFPES YDREDTMVLV CNMGNLILKT QPHNSEWDSM DFSEINEQDE TDEIFVRYCN
LLKDRVKWWS DNCPIKKINE PIEKQSYIIN YVQQHRQTIE NLGTGNGINN NNSGGGGNGG
NASNSSEDDG KYPEQDDLDD SKVEKEGFDS CDTDWNKVSV NINNAQFYDG IVLTISDIYV
KVCDCTQINN FNYLISPFSL DIFLELCSRP YDLKLPQIKC KAELSELNLQ VSDKELYEIA
KIVGKNGILE YFMDMDRKSS KELADMYEIV QVKKPKKKSF EVQFSLFSDT KSILNSRKRT
KERLVKTTLL RFFFTSNAIN MKLNYLDSCT LSLTMDQIRC RSLVKFMQMN IQFDISSIEI
KDSNSITPVL SIFPYNLNNN NNNNNNNNNN NNNNNNNNNN RNLNNNNNNN NNNQKPECLN
EFPISITAKS ISKNSLDYDY IDFVLTLTTQ YIRINFPKEC VMALIAIIGT VVTNTTNFYE
TKKSILTVEG SFYQGRVGQF TQSNTTTTTS PRYHHQNHHN HQHKKQNRHR LSTRLETNEF
DPNDLKSKIT INIPSFGLTL STIENDLVAF QFEDISIDGI FQLPLIDCEL KVRDMKFIDY
TGSDGPYPYM LITQKSQSPM VPVVRMHLVC HSNSKTQEWG FSRLINIAVG KIQITFLLQT
INLIRLFIHD ITSSLKEYCP FLFKVMAIVD DNNKPSSKDN NNNNNNNNNS DSDSDSDTDS
SSSSENNYNN NIDLNSPVVE IVKKKKNLTN LEIEIDNNVV IVPKNSRSRS AIRFSVGRIL
LGLDQMDPTV DAVFVKIYGI NMASKYEDSI DPIISDPIKM DIRFIHMFET SLKDKSIEVI
IKIDKIHLKL SQYQYNLLYN TYQQNINQSI VPAPPSNSYS TVERQDILLD IRLEFKDFVE
LNLENEKTND SRFFSMLIQR PIICCSVWNN GDSDFLIKTT GISVRDKNKL VVVPNGFQEM
INITPYDLDV PIKNVINQSI NEVFFDIVKM NIDDNGIDIN ITIEYLSIFF DLPWVSKLIT
FLSPIIDADY IGNSCSNSTN KSSTTINTQL LPPPPPPPPI SLNKSGVNLT NQQQNEEFNS
KFNKDWKIFL KVEVSAKNAN IMVGDLNSKN ELVLLMNSSL LINSQFGTEG LMKIILEYQC
IKGLIGNKTK DPIYSTKNPS ATTMSFISAS SRDLGAQKNT THYLWKELKK SSKLFLETFK
TNIQVCLVPE GNQFYFCELN DLSLVFSGKA YKYLLDIYEC VSDIIYGVSK SKDITNNNLV
QKHSRSSSIS TDLPIPINLR RSSIISTNLM QQQQQQQQQQ QQQQQQQQQQ QQQQQQNNNN
NQNNQASSNN NNNNNNNVSG NTINNKSVPN VHDKTKNQFY QIKTRSVEML RAHQTRVTEK
YQASLPSNGK IAETEENENG DHTFTSDDDD DEGEDEDIGE GFSLDHSTSS APTSRSNYNN
INEPMIDLKS SKKQDDSNMV TKIQFSQISI SIKNLNIIIM DDLSKHKMNT PIFNMKLNYG
FMKAVLKTTR IEVEFDSVFQ MNYFNNRIAY WEPFIEPWLF KSMMTLGKEL SIDIYSTDLL
NINFTIPLMD NISLFLRTYS KEFGYPFNLI CAPSDSNNTD NSSNNGKKSH SNRHSLIGQI
KKIKEKKTKT SYSPFFIRNR TGSRLRYRLE TQDGKPVAGV NHKMEGSTVR VVNIENYGLF
FELDSGDCSP IKFLPDVQIN LETFSQLVLA VELLGVEKSI SIPLDKIKIY DYQVYLDSST
STKLYANIGI KNGTKLITIQ FPIVLKNLTS FPIDIATVTS GFGDTQMPNY STTIRVGQAR
APLPINRMRN VQIKFKPSGD QYKWSTEALD VNNVIEGEDK FSCILKNGEK IYYIKGYIFK
KNQCFIIKLC HMLKVKNLLP YPIQFKLKSP IENIPLLKRE TQATVQDQEK TEVYEIPLLD
KFKIQVRIAD KDGTFEKSEW SEIRSIVERE DNNEIGVITI SDSNNLIVDY LHLNVEFESY
KGEKKIVFYN QYWIFNKSGL NLYCKKSYHS KDYSESQTHF NHPLQQLDSS NTNTTIKPSD
AIIVTPDQWY SHQLIKESPL LFSFKKLKDM ENSIRIRVGD SKWSHKISIA AIGDRGTIVI
DSSEKRHSRS YHLGLSVDLA PNLKTKIVVF TPRFVFHNLF PYTILVQQCG ANTDSTTIRI
PPSCSVPFYY FINNTGESSK PTLKFKIDYQ EFDWSPPFSI QTFSDFTFNV FNNNNNDNVE
NYKQPDIHCN PYIRIKTCLE VATILVIISE LKEPPYRILN NTKYQLSIQQ KKVGKVLTVE
PSSSIPYVWD LPLEDHILEV LVHISTNQSE KASYKMDKIK TFRPMEFNDD HNPVVIKAIV
EADESTRVLT LSDKTSFQIS KYEEENLRQS FRIHFTGIGI SVINANPTEL LYVSIHDILC
EYFISSFLQK LEMKITNIQV DNQLSKVTPY SHPVLLFADN LLPNTPFLQV RIVRSMKMKN
IDYYHHVSLK MQELNIKVEE KFLYVLLDFF NSLDFSFWTG NKKTNTLHNM DMLTPMYNED
IGEGFIDEMV ARALPSIYGK KMYFESLDIE PISMFLTFDL SNKSGSIASL EQAPMVKAFR
RIGFVIVSFQ HAHIFLHGFS LSHAFGSNEE LLAPIFNHYF SEGLSEVYKI LGAFNLFGNP
VGLVTNFGIG FKEFFVSMGK GLVGNSFTDS FGQGSKSLAK HSVYGIFDSG AKLTGSAGKV
LSTLSMDQRY ILERQYIIGE SPNTFMQGLI LGGRAAKTAV YRGFSGFVKL PYEGGKEAGP
KGVVKGIGKG TAGLVLKPIA AGFDFASKVS EGIKNSTQLS IERKRIRFPR PLFSDSPLET
YDSAESYGHF LFLTYIITAG KLRRISADQI NLPLMEVVSK DEKYVSHLIY KNRKTLLFTN
KRIIYLYDTD GFRTKFDIKY TRIHGVSEKS DHIDIKIDKK HKLSFLYNEK NKKIDYRIKC
VGEEKSYIFY RIIEMIKTYK PFADEELTVN GLKADPTTMI PIPPPPPPPL QQQLLYGSNI
IQQQPPIQYF NDGSSSSSNL TGGRTIQPII FTNDAGPMRN DLNPILENLL AQQPNKNMEI
PIWISQGFNP PKPPDTLIPQ RFRDPNLINN NNNYYYPNGS GYVYSQPPLY DQYGNQIPPP
PPLPSHPLAI DRPTTTTTTN TTTTPYQSSQ NIHSTPYPTE TPQSVVLKED ISKAIHTPSA
SSLKKLKTPH HYNVRFEPSS SLGPQDFDIH TIRLQNQQYQ HSGSGAPPPP PIITTTTNST
IPPPSSNINQ RQLQHQFSSN SIIETPRYKS MARQQQFQQP PPPPPLPSNN RLSLTPSGSG
NINYSDKFEV ALNTIIQIQK IQSQQMSSLQ KNQRDLQKLL FQQQSTEFDT LRNQQEQIQN
IISQYHPLSP SKASLVSKLS NELESTNSNV VISPPTGGAS N
