VP13L_DICDI
ID VP13L_DICDI Reviewed; 653 AA.
AC Q86K84; Q550C0;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Intermembrane lipid transfer protein vps13l {ECO:0000250|UniProtKB:Q96RL7};
DE AltName: Full=Vacuolar protein sorting-associated protein 13-like protein;
GN Name=vps13l; ORFNames=DDB_G0277219;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites. {ECO:0000250|UniProtKB:Q07878}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the VPS13 family. {ECO:0000305}.
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DR EMBL; AAFI02000019; EAL68795.1; -; Genomic_DNA.
DR RefSeq; XP_642696.1; XM_637604.1.
DR AlphaFoldDB; Q86K84; -.
DR PaxDb; Q86K84; -.
DR EnsemblProtists; EAL68795; EAL68795; DDB_G0277219.
DR GeneID; 8620886; -.
DR KEGG; ddi:DDB_G0277219; -.
DR dictyBase; DDB_G0277219; vps13l.
DR eggNOG; KOG1809; Eukaryota.
DR HOGENOM; CLU_420064_0_0_1; -.
DR InParanoid; Q86K84; -.
DR OMA; KPENSIM; -.
DR PRO; PR:Q86K84; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR015412; Autophagy-rel_C.
DR InterPro; IPR000315; Znf_B-box.
DR Pfam; PF09333; ATG_C; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
PE 3: Inferred from homology;
KW Membrane; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..653
FT /note="Intermembrane lipid transfer protein vps13l"
FT /id="PRO_0000366145"
FT ZN_FING 5..49
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT REGION 159..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..382
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 10
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 13
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 32
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 37
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 653 AA; 71928 MW; A5064A538E150D62 CRC64;
MKLNISELKC QQHDKLVTIY CCACDAYFCK KCDKEKHSQD DNQEDSLHIR GLVNKDVIIG
RDEEDDDDED DEYDNKIQDI LKKSNNLKKS NSIGGNIVEN IELKSPMKTD SPYFIRDKNS
IQSDIDSKIT EKIDLDNLIH EEDDPFTIGI NSNNSNSNNL IDVNDLHTPS TPSPLPSPSL
SRSSSTNIKP QQQTSPSPSR SSESNSTTNN NNNKNEKKKL KNSSNSELNR KKIYKKEKII
GDSDEEEHIL NNGNKNKNNK SKSVYDYDDD DDNDDDNNNN NNNNNNNNNN NNNENDDNSN
SKSEGGVFYS SSSETEKEIE NVENKIDNKP KPPNKSLPKT PQSNKKKKPE NSIMVKNLDS
GLVEQIFEEE EEEEEDEDEV GSESGGGGTI FKNPYSNRKN KSGKYKSNSC ALEEGEEDDS
SIQSQFDGEE KEAVHIVQGI VEGAILFGTN IATGLSGIVA EPIINIVDNQ DNKVKGFFKG
VGKGLLGAVT SPVKGGSGFL IKTAEGLRNT PATVFHGDHE DLMGFSDADQ VKEREASHIF
EGIAQGTISL SKNLYLGVTG IVTEPIKGLR EDENNKAKGF FKGVGKGLMG AIVKPASGII
EMAGKTAEGI ANTPHTIINA IEMKIDEKSN NNNNNNNLDS DSEGETYVNP NEN
