ID   VP16_GAHVM              Reviewed;         427 AA.
AC   Q77MR5;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   12-AUG-2020, entry version 38.
DE   RecName: Full=Tegument protein VP16 homolog;
DE   AltName: Full=Alpha trans-inducing protein;
DE   AltName: Full=Alpha-TIF;
DE   AltName: Full=ORF10 protein;
DE   AltName: Full=Tegument protein 10;
GN   Name=MDV061;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Transcriptional activator of immediate-early (IE) gene
CC       products (alpha genes). Acts as a key activator of lytic infection by
CC       initiating the lytic program through the assembly of the
CC       transcriptional regulatory VP16-induced complex composed of VP16 and
CC       two cellular factors, HCFC1 and POU2F1. VP16-induced complex represents
CC       a regulatory switch: when it is on, it promotes IE-gene expression and
CC       thus lytic infection, and when it is off, it limits IE-gene
CC       transcription favoring latent infection (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: May play a role in the aggregation of tegument proteins
CC       around nucleocapsids during virus morphogenesis. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P04486}.
CC       Host nucleus {ECO:0000250|UniProtKB:P04486}.
CC   -!- SIMILARITY: Belongs to the herpesviridae tegument protein VP16 protein
CC       family. {ECO:0000305}.
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DR   EMBL; AF243438; AAG14241.1; -; Genomic_DNA.
DR   RefSeq; YP_001033977.1; NC_002229.3.
DR   SMR; Q77MR5; -.
DR   GeneID; 4811522; -.
DR   KEGG; vg:4811522; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039695; P:DNA-templated viral transcription; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1290.10; -; 1.
DR   InterPro; IPR003174; Alpha_TIF.
DR   InterPro; IPR036538; Alpha_TIF_sf.
DR   Pfam; PF02232; Alpha_TIF; 1.
DR   SMART; SM00814; Alpha_TIF; 1.
DR   SUPFAM; SSF56548; SSF56548; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Host nucleus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Virion; Virion tegument.
FT   CHAIN           1..427
FT                   /note="Tegument protein VP16 homolog"
FT                   /id="PRO_0000406497"
SQ   SEQUENCE   427 AA;  48658 MW;  704C23E34A3FBBAB CRC64;
     MEANMSFEND YYSPIQLFAE IEAYANTMDK SPDLDILRTI EEFDETLLSE IEVRTQSIPS
     PLVAPSVTKM SLPSPSPAPP NSLYTRLLHE LDFVEGPSIL ARLEKINVDL FSCFPHNKHL
     YEHAKILSVS PSEVLEELSK NTWTYTALNL NEHGEMALPM PPTTKADLPS YVDDIQNFYL
     GELEAREKSY ATMFYGYCRA LAEYIRQSAI KDLRDARVED KNIGACSKAR QYIAERYYRE
     AARFAKLLYV HLYLSTTRDV SQRLEASQMG RQNIFVYLKC EWLQERHFHC LFQPVIFNHG
     VVIVEGRVLT APELRAQNYI RSEFGLPLIR CKLVEEPDMP LISPPPFSGD APRASVYLLQ
     CIRSKLEVYS LSHPPNPQLH VHKEHVHVQK LESPPNYGTT VEALLMDSSD RNSISPGDPV
     ATTISTL