ID   VP16_VZVO               Reviewed;         410 AA.
AC   Q4JQW5; Q4JQY8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   02-JUN-2021, entry version 55.
DE   RecName: Full=Tegument protein VP16 homolog;
DE   AltName: Full=Alpha trans-inducing protein;
DE   AltName: Full=Alpha-TIF;
DE   AltName: Full=ORF10 protein;
DE   AltName: Full=Tegument protein 10;
GN   ORFNames=ORF10;
OS   Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=341980;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC   Oka varicella vaccine Biken (V-Oka-Biken);
RX   PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA   Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT   its parental virus.";
RL   J. Virol. 76:11447-11459(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC   Oka varicella vaccine Varivax (V-Oka-Merk);
RX   PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA   Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA   Vassilev V.;
RT   "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL   J. Virol. 82:11023-11044(2008).
CC   -!- FUNCTION: Transcriptional activator of immediate-early (IE) gene
CC       products (alpha genes). Acts as a key activator of lytic infection by
CC       initiating the lytic program through the assembly of the
CC       transcriptional regulatory VP16-induced complex composed of VP16 and
CC       two cellular factors, HCFC1 and POU2F 1. VP16-induced complex
CC       represents a regulatory switch: when it is on, it promotes IE-gene
CC       expression and thus lytic infection, and when it is off, it limits IE-
CC       gene transcription favoring latent infection (By similarity).
CC       {ECO:0000250}.
CC   -!- FUNCTION: May play a role in the aggregation of tegument proteins
CC       around nucleocapsids during virus morphogenesis. {ECO:0000305}.
CC   -!- SUBUNIT: Associates with the VP16-induced complex; binding to host
CC       HCFC1 activates VP16 for association with the octamer motif-binding
CC       host protein POU2F1, to form a multiprotein-DNA complex responsible for
CC       activating transcription of the viral immediate early genes.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P04486}.
CC       Host nucleus {ECO:0000250|UniProtKB:P04486}.
CC   -!- SIMILARITY: Belongs to the herpesviridae tegument protein VP16 protein
CC       family. {ECO:0000305}.
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DR   EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ008354; AAY57628.1; -; Genomic_DNA.
DR   EMBL; DQ008355; AAY57699.1; -; Genomic_DNA.
DR   SMR; Q4JQW5; -.
DR   IntAct; Q4JQW5; 3.
DR   MINT; Q4JQW5; -.
DR   Proteomes; UP000002603; Genome.
DR   Proteomes; UP000008504; Genome.
DR   Proteomes; UP000008505; Genome.
DR   Proteomes; UP000008506; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039695; P:DNA-templated viral transcription; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1290.10; -; 1.
DR   InterPro; IPR003174; Alpha_TIF.
DR   InterPro; IPR036538; Alpha_TIF_sf.
DR   Pfam; PF02232; Alpha_TIF; 1.
DR   SMART; SM00814; Alpha_TIF; 1.
DR   SUPFAM; SSF56548; SSF56548; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Host nucleus; Phosphoprotein; Transcription;
KW   Transcription regulation; Virion; Virion tegument.
FT   CHAIN           1..410
FT                   /note="Tegument protein VP16 homolog"
FT                   /id="PRO_0000385480"
FT   REGION          388..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   410 AA;  46555 MW;  332A11D7597ABBC7 CRC64;
     MECNLGTEHH STDTWNRSKT EQAVVDAFDE SLFGDVASDI GSETSLYSHA VKTAPSPPWV
     ASPKILYQQL IRDLDFSEGP RLLSCLETWN EDLFSCFPIN EDLYSDMMVL SPDPDDVIST
     VSTKDHVEMF NLTTRGSVRL PSPPKQPTGL PAYVQEVQDS FTVELRAREE AYTKLLVTYC
     KSIIRYLQGT AKRTTIGLNI QNPDQKAYTQ LRQSILLRYY REVASLARLL YLHLYLTVTR
     EFSWRLYASQ SAHPDVFAAL KFTWTERRQF TCAFHPVLCN HGIVLLEGKP LTASALREIN
     YRRRELGLPL VRCGLVEENK SPLVQQPSFS VHLPRSVGFL THHIKRKLDA YAVKHPQEPR
     HVRADHPYAK VVENRNYGSS IEAMILAPPS PSEILPGDPP RPPTCGFLTR