ID   VP242_ARATH             Reviewed;         200 AA.
AC   Q9LXH5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Putative vacuolar protein sorting-associated protein 24 homolog 2;
DE            Short=AtVPS24-2;
DE   AltName: Full=Charged multivesicular body protein 3 homolog 2;
DE   AltName: Full=ESCRT-III complex subunit VPS24 homolog 2;
GN   Name=VPS24-2; Synonyms=CHMP3-2; OrderedLocusNames=At3g45000;
GN   ORFNames=F14D17.70;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   IDENTIFICATION, AND NOMENCLATURE.
RX   PubMed=17090720; DOI=10.1242/dev.02654;
RA   Spitzer C., Schellmann S., Sabovljevic A., Shahriari M., Keshavaiah C.,
RA   Bechtold N., Herzog M., Mueller S., Hanisch F.-G., Huelskamp M.;
RT   "The Arabidopsis elch mutant reveals functions of an ESCRT component in
RT   cytokinesis.";
RL   Development 133:4679-4689(2006).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=16488176; DOI=10.1016/j.tplants.2006.01.008;
RA   Winter V., Hauser M.-T.;
RT   "Exploring the ESCRTing machinery in eukaryotes.";
RL   Trends Plant Sci. 11:115-123(2006).
CC   -!- FUNCTION: Component of the ESCRT-III complex, which is required for
CC       multivesicular bodies (MVBs) formation and sorting of endosomal cargo
CC       proteins into MVBs. The ESCRT-III complex is probably involved in the
CC       concentration of MVB cargo (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the endosomal sorting required for transport
CC       complex III (ESCRT-III), composed at least of VPS2, VPS20, VPS24 and
CC       VPS32. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q9LXH5-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; AL353992; CAB89315.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE77977.1; -; Genomic_DNA.
DR   PIR; T48976; T48976.
DR   RefSeq; NP_190086.1; NM_114369.1. [Q9LXH5-1]
DR   AlphaFoldDB; Q9LXH5; -.
DR   SMR; Q9LXH5; -.
DR   STRING; 3702.AT3G45000.1; -.
DR   TCDB; 3.A.31.1.2; the endosomal sorting complexes required for transport iii (escrt-iii) family.
DR   PaxDb; Q9LXH5; -.
DR   PRIDE; Q9LXH5; -.
DR   EnsemblPlants; AT3G45000.1; AT3G45000.1; AT3G45000. [Q9LXH5-1]
DR   GeneID; 823635; -.
DR   Gramene; AT3G45000.1; AT3G45000.1; AT3G45000. [Q9LXH5-1]
DR   KEGG; ath:AT3G45000; -.
DR   Araport; AT3G45000; -.
DR   TAIR; locus:2075924; AT3G45000.
DR   eggNOG; KOG3229; Eukaryota.
DR   HOGENOM; CLU_069208_0_0_1; -.
DR   InParanoid; Q9LXH5; -.
DR   OMA; EERNVHK; -.
DR   OrthoDB; 1418709at2759; -.
DR   PhylomeDB; Q9LXH5; -.
DR   PRO; PR:Q9LXH5; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LXH5; baseline and differential.
DR   Genevisible; Q9LXH5; AT.
DR   GO; GO:0000815; C:ESCRT III complex; ISS:TAIR.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Coiled coil; Endosome; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..200
FT                   /note="Putative vacuolar protein sorting-associated protein
FT                   24 homolog 2"
FT                   /id="PRO_0000368199"
FT   COILED          2..23
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   200 AA;  22037 MW;  0C3143D8530B7607 CRC64;
     MTIKSLLSDI EREERNVHKA IKDSVKRNDL VTAKALAREI VSSRRTVKRL YENKAQVNSI
     SMHLGESIAT AVTVGNLSKS GEVMKLVNSL MKAPEIAVTM QAFSKEMTKT GVIEEFVSDA
     VDNALDSEDI EEEIEEEVDK VLTAIAGETA AELPEAVRKQ KMNVPAQKAE TLHGEDAIVE
     GVDAEEELEA IRYRLANVRS