ID   VP24_EBOG4              Reviewed;         251 AA.
AC   O11459; Q6YNP9;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Membrane-associated protein VP24;
DE   AltName: Full=Ebola VP24;
DE            Short=eVP24;
GN   Name=VP24;
OS   Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Filoviridae; Ebolavirus.
OX   NCBI_TaxID=128947;
OH   NCBI_TaxID=77231; Epomops franqueti (Franquet's epauleted fruit bat).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=77243; Myonycteris torquata (Little collared fruit bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9185597; DOI=10.1006/viro.1997.8529;
RA   Volchkov V., Volchkova V., Eckel C., Klenk H.-D., Bouloy M., Leguenno B.,
RA   Feldmann H.;
RT   "Emergence of subtype Zaire Ebola virus in Gabon.";
RL   Virology 232:139-144(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Isolate Bouee-96;
RX   PubMed=11752702; DOI=10.1099/0022-1317-83-1-67;
RA   Leroy E.M., Baize S., Mavoungou E., Apetrei C.;
RT   "Sequence analysis of the GP, NP, VP40 and VP24 genes of Ebola virus
RT   isolated from deceased, surviving and asymptomatically infected individuals
RT   during the 1996 outbreak in Gabon: comparative studies and phylogenetic
RT   characterization.";
RL   J. Gen. Virol. 83:67-73(2002).
CC   -!- FUNCTION: Prevents the establishment of cellular antiviral state by
CC       blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma
CC       signaling pathways. Blocks the IFN-induced nuclear accumulation of host
CC       phosphorylated STAT1 by interacting with the STAT1-binding region of
CC       host importins. Alternatively interacts also directly with host STAT1
CC       and may additionally inhibit its non-phosphorylated form. Plays a role
CC       in assembly of viral nucleocapsid and virion budding. May act as a
CC       minor matrix protein that plays a role in assembly of viral
CC       nucleocapsid and virion budding. {ECO:0000250|UniProtKB:Q05322}.
CC   -!- SUBUNIT: Interacts with host importins KPNA1, KPNA5 and KPNA6.
CC       Interacts with host STAT1. Interacts with host KEAP1; this interaction
CC       activates host transcription factor NRF2 by blocking its interaction
CC       with KEAP1. {ECO:0000250|UniProtKB:Q05322}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250|UniProtKB:Q05322};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:Q05322}. Host cell
CC       membrane {ECO:0000250|UniProtKB:Q05322}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q05322}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q05322}. Host endomembrane system
CC       {ECO:0000250|UniProtKB:Q05322}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q05322}. Note=In virion, localizes on the
CC       intravirional side of the membrane. In the host cell, it is found
CC       associated with virus-induced membrane proliferation foci and to the
CC       plasma membrane where budding takes place (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the filoviridae membrane-associated protein VP24
CC       family. {ECO:0000305}.
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DR   EMBL; U77385; AAC57991.1; -; Genomic_RNA.
DR   EMBL; AY058897; AAL25817.1; -; mRNA.
DR   SMR; O11459; -.
DR   GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR009433; Filo_VP24.
DR   Pfam; PF06389; Filo_VP24; 1.
DR   PIRSF; PIRSF011355; VP24; 1.
PE   2: Evidence at transcript level;
KW   Host cell membrane; Host membrane; Host-virus interaction;
KW   Interferon antiviral system evasion; Membrane; Virion.
FT   CHAIN           1..251
FT                   /note="Membrane-associated protein VP24"
FT                   /id="PRO_0000222155"
SQ   SEQUENCE   251 AA;  28216 MW;  CD114B6AF2CC5A59 CRC64;
     MAKATGRYNL ISPKKDLEKG VVLSDLCNFL VSQTIQGWKV YWAGIEFDVT HKGMALLHRL
     KTNDFAPAWS MTRNLFPHLF QNPNSTIESP LWALRVILAA GIQDQLIDQS LIEPLAGALG
     LISDWLLTTN TNHFNMRTQR VKEQLSLKML SLIRSNILKF INKLDALHVV NYNGLLSSIE
     IGTQNHTIII TRTNMGFLVE LQEPDKSAMN RKKPGPAKFS LLHESTLKAF TQGSSTRMQS
     LILEFNSSLA I