ID   VP24_EBORR              Reviewed;         251 AA.
AC   Q77DB4;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Membrane-associated protein VP24;
DE   AltName: Full=Reston VP24;
DE            Short=rVP24;
GN   Name=VP24; ORFNames=REBOVgp6;
OS   Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Filoviridae; Ebolavirus.
OX   NCBI_TaxID=386032;
OH   NCBI_TaxID=77231; Epomops franqueti (Franquet's epauleted fruit bat).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=77243; Myonycteris torquata (Little collared fruit bat).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=12191779; DOI=10.1016/s0168-1702(02)00087-4;
RA   Groseth A., Stroeher U., Theriault S., Feldmann H.;
RT   "Molecular characterization of an isolate from the 1989/90 epizootic of
RT   Ebola virus Reston among macaques imported into the United States.";
RL   Virus Res. 87:155-163(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15661171; DOI=10.1016/j.virol.2004.11.018;
RA   Boehmann Y., Enterlein S., Randolf A., Muehlberger E.I.;
RT   "A reconstituted replication and transcription system for Ebola virus
RT   Reston and comparison with Ebola virus Zaire.";
RL   Virology 332:406-417(2005).
CC   -!- FUNCTION: Prevents the establishment of cellular antiviral state by
CC       blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma
CC       signaling pathways. Blocks the IFN-induced nuclear accumulation of host
CC       phosphorylated STAT1, by interacting with the STAT1-binding region of
CC       host importin alpha-1/KPNA1 protein, thereby inhibiting the latter.
CC       Without the activity of this protein, activated STAT1 would not enter
CC       the nucleus and be unable to activate IFN-induced genes. Plays a role
CC       in assembly of viral nucleocapsid and virion budding. May act as a
CC       minor matrix protein that plays a role in assembly of viral
CC       nucleocapsid and virion budding.
CC   -!- SUBUNIT: Interacts with host importins KPNA1, KPNA5 and KPNA6.
CC       Interacts with host STAT1. {ECO:0000250|UniProtKB:Q91DD5}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Host cell membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}. Host endomembrane system {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Note=In virion, localizes on the
CC       intravirional side of the membrane. In the host cell, it is found
CC       associated with virus-induced membrane proliferation foci and to the
CC       plasma membrane where budding takes place (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the filoviridae membrane-associated protein VP24
CC       family. {ECO:0000305}.
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DR   EMBL; AF522874; AAN04453.1; -; Genomic_RNA.
DR   EMBL; AY769362; AAV48580.1; -; Genomic_RNA.
DR   RefSeq; NP_690586.1; NC_004161.1.
DR   SMR; Q77DB4; -.
DR   GeneID; 955193; -.
DR   KEGG; vg:955193; -.
DR   Proteomes; UP000007207; Genome.
DR   Proteomes; UP000138664; Genome.
DR   GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR009433; Filo_VP24.
DR   Pfam; PF06389; Filo_VP24; 1.
DR   PIRSF; PIRSF011355; VP24; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host membrane; Host-virus interaction;
KW   Interferon antiviral system evasion; Membrane; Virion.
FT   CHAIN           1..251
FT                   /note="Membrane-associated protein VP24"
FT                   /id="PRO_0000245068"
SQ   SEQUENCE   251 AA;  28169 MW;  DB8F144CA8FB2509 CRC64;
     MAKATGRYNL VPPKKDMEKG VIFSDLCNFL ITQTLQGWKV YWAGIEFDVS QKGMALLTRL
     KTNDFAPAWA MTRNLFPHLF QNPNSVIQSP IWALRVILAA GLQDQLLDHS LVEPLTGALG
     LISDWLLTTT STHFNLRTRS VKDQLSLRML SLIRSNILQF INKLDALHVV NYNGLLSSIE
     IGTSTHTIII TRTNMGFLVE VQEPDKSAMN SKRPGPVKFS LLHESAFKPF TRVPQSGMQS
     LIMEFNSLLA I