VP24_EBOZ5
ID VP24_EBOZ5 Reviewed; 251 AA.
AC Q6V1Q3;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Membrane-associated protein VP24;
DE AltName: Full=Ebola VP24;
DE Short=eVP24;
GN Name=VP24;
OS Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Filoviridae; Ebolavirus.
OX NCBI_TaxID=128951;
OH NCBI_TaxID=77231; Epomops franqueti (Franquet's epauleted fruit bat).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=77243; Myonycteris torquata (Little collared fruit bat).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA Chain P.S.G., Ichou M.A., Malfatti S.A., Hajjaj A., Vergez L.M.,
RA Paragas J., Do L.H., Jahrling P.B., Smith K.L., McCready P.M.,
RA Ibrahim M.S.;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Prevents the establishment of cellular antiviral state by
CC blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma
CC signaling pathways. Blocks the IFN-induced nuclear accumulation of host
CC phosphorylated STAT1 by interacting with the STAT1-binding region of
CC host importins. Alternatively interacts also directly with host STAT1
CC and may additionally inhibit its non-phosphorylated form. Plays a role
CC in assembly of viral nucleocapsid and virion budding. May act as a
CC minor matrix protein that plays a role in assembly of viral
CC nucleocapsid and virion budding. {ECO:0000250|UniProtKB:Q05322}.
CC -!- SUBUNIT: Interacts with host importins KPNA1, KPNA5 and KPNA6.
CC Interacts with host STAT1. Interacts with host KEAP1; this interaction
CC activates host transcription factor NRF2 by blocking its interaction
CC with KEAP1. {ECO:0000250|UniProtKB:Q05322}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250|UniProtKB:Q05322};
CC Peripheral membrane protein {ECO:0000250|UniProtKB:Q05322}. Host cell
CC membrane {ECO:0000250|UniProtKB:Q05322}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q05322}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q05322}. Host endomembrane system
CC {ECO:0000250|UniProtKB:Q05322}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q05322}. Note=In virion, localizes on the
CC intravirional side of the membrane. In the host cell, it is found
CC associated with virus-induced membrane proliferation foci and to the
CC plasma membrane where budding takes place (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the filoviridae membrane-associated protein VP24
CC family. {ECO:0000305}.
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DR EMBL; AY354458; AAQ55052.1; -; Genomic_RNA.
DR SMR; Q6V1Q3; -.
DR Proteomes; UP000007208; Genome.
DR GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0016032; P:viral process; IEA:InterPro.
DR InterPro; IPR009433; Filo_VP24.
DR Pfam; PF06389; Filo_VP24; 1.
DR PIRSF; PIRSF011355; VP24; 1.
PE 3: Inferred from homology;
KW Host cell membrane; Host membrane; Host-virus interaction;
KW Interferon antiviral system evasion; Membrane; Reference proteome; Virion.
FT CHAIN 1..251
FT /note="Membrane-associated protein VP24"
FT /id="PRO_0000245070"
SQ SEQUENCE 251 AA; 28235 MW; CAAD49C369E1C969 CRC64;
MAKATGRYNL ISPKKDLEKG VVLSDLCNFL VSQTIQGWKV YWAGIEFDVT HKGMALLQRL
KTNDFAPAWS MTRNLFPHLF QNPNSTIESP LWALRVILAA GIQDQLIDQS LIEPLAGALG
LISDWLLTTN TNHFNMRTQR VKEQLSLKML SLIRSNILKF INRLDALHVV NYNGLLSSIE
IGTQNHTIII TRTNMGFLVE LQEPDKSAMN RKKPGPAKFS LLHESTLKAF TQGSSTRMQS
LILEFNSSLA I