ID   VP24_MABVA              Reviewed;         253 AA.
AC   Q1PD62;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Membrane-associated protein VP24;
DE   AltName: Full=Marburg VP24;
DE            Short=mVP24;
GN   Name=VP24;
OS   Lake Victoria marburgvirus (strain Angola/2005) (MARV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Filoviridae; Marburgvirus.
OX   NCBI_TaxID=378830;
OH   NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9407; Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate Ang0214, Isolate Ang0215, Isolate Ang1379c, and
RC   Isolate Ang1386;
RX   PubMed=16775337; DOI=10.1128/jvi.00069-06;
RA   Towner J.S., Khristova M.L., Sealy T.K., Vincent M.J., Erickson B.R.,
RA   Bawiec D.A., Hartman A.L., Comer J.A., Zaki S.R., Stroeher U.,
RA   Gomes da Silva F., del Castillo F., Rollin P.E., Ksiazek T.G., Nichol S.T.;
RT   "Marburgvirus genomics and association with a large hemorrhagic fever
RT   outbreak in Angola.";
RL   J. Virol. 80:6497-6516(2006).
CC   -!- FUNCTION: May act as a minor matrix protein that plays a role in
CC       assembly of viral nucleocapsid and virion budding. Unlike Ebola VP24,
CC       mVP24 has no measurable impact of host dendritic cell function.
CC       {ECO:0000250|UniProtKB:P35256}.
CC   -!- SUBUNIT: Monomer or homotetramer (Potential). Interacts with the
CC       nucleoprotein (By similarity). {ECO:0000250, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Host cell membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}. Host endomembrane system {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Note=In virion, localizes on the
CC       intravirional side of the membrane. In the host cell, it is found
CC       associated with virus-induced membrane proliferation foci and to the
CC       plasma membrane where budding takes place (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the filoviridae membrane-associated protein VP24
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ447653; ABE27017.1; -; Genomic_RNA.
DR   EMBL; DQ447655; ABE27031.1; -; Genomic_RNA.
DR   EMBL; DQ447657; ABE27045.1; -; Genomic_RNA.
DR   EMBL; DQ447658; ABE27052.1; -; Genomic_RNA.
DR   SMR; Q1PD62; -.
DR   PRIDE; Q1PD62; -.
DR   Proteomes; UP000008242; Genome.
DR   Proteomes; UP000115353; Genome.
DR   Proteomes; UP000130744; Genome.
DR   Proteomes; UP000171838; Genome.
DR   GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR009433; Filo_VP24.
DR   Pfam; PF06389; Filo_VP24; 1.
DR   PIRSF; PIRSF011355; VP24; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host membrane; Membrane; Reference proteome;
KW   Viral matrix protein; Virion.
FT   CHAIN           1..253
FT                   /note="Membrane-associated protein VP24"
FT                   /id="PRO_0000314989"
SQ   SEQUENCE   253 AA;  28705 MW;  E4661E05176C2CB3 CRC64;
     MAELSTRYNL PVNVTEKSIN LDLNSTARWI KEPSVGGWTV KWGNFVFHIP NTGMTLLHHL
     KSNFVVPEWQ QTRNLFSHLF KNPKSTIIEP FLALRILLGV ALKDQELQQS LIPGFRSIVH
     MLSEWLLLEV TSAIHISPNL LGIYLTSDMF KILMAGVKNF FNKMFTLHVV NDHGKPSSIE
     IKLTGQQIII TRVNMGFLVE VRRIDIEPCC GETVLLESVV FGLVAEAVLR EHSQMEKGQP
     LNLTQYMNSK IAI