VP24_MABVM
ID VP24_MABVM Reviewed; 253 AA.
AC P35256; Q38L40; Q6T6T8;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 29-SEP-2021, entry version 74.
DE RecName: Full=Membrane-associated protein VP24;
DE AltName: Full=Marburg VP24 {ECO:0000303|PubMed:26962215};
DE Short=mVP24 {ECO:0000303|PubMed:26962215};
GN Name=VP24;
OS Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain
OS Kenya/Musoke/1980)).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Filoviridae; Marburgvirus.
OX NCBI_TaxID=33727;
OH NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9407; Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat).
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1626422; DOI=10.1016/0168-1702(92)90027-7;
RA Feldmann H., Muehlberger E., Randolf A., Will C., Kiley M.P., Sanchez A.,
RA Klenk H.-D.;
RT "Marburg virus, a filovirus: messenger RNAs, gene order, and regulatory
RT elements of the replication cycle.";
RL Virus Res. 24:1-19(1992).
RN [2]
RP SEQUENCE REVISION.
RA Feldmann H.;
RL Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=pp3/guinea pig lethal, and pp4/guinea pig nonlethal;
RA Chain P.S.G., Malfatti S.A., Hajjaj A., Vergez L.M., Do L.H., Smith K.L.,
RA McCready P.M.;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=pp3/guinea pig lethal, and pp4/guinea pig nonlethal;
RA Ichou M.A., Paragas J., Jahrling P.B., Ibrahim M.S., Lofts L., Hevey M.,
RA Schmaljohn A.;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate Enterlein;
RX PubMed=16379005; DOI=10.1128/jvi.80.2.1038-1043.2006;
RA Enterlein S., Volchkov V., Weik M., Kolesnikova L., Volchkova V.,
RA Klenk H.-D., Muehlberger E.;
RT "Rescue of recombinant Marburg virus from cDNA is dependent on nucleocapsid
RT protein VP30.";
RL J. Virol. 80:1038-1043(2006).
RN [6]
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND INTERACTION WITH THE
RP NUCLEOPROTEIN.
RX PubMed=16227263; DOI=10.1128/jvi.79.21.13421-13433.2005;
RA Bamberg S., Kolesnikova L., Moeller P., Klenk H.-D., Becker S.;
RT "VP24 of Marburg virus influences formation of infectious particles.";
RL J. Virol. 79:13421-13433(2005).
RN [7]
RP FUNCTION, AND NOMENCLATURE.
RX PubMed=26962215; DOI=10.1128/jvi.00191-16;
RA Yen B.C., Basler C.F.;
RT "Effects of Filovirus Interferon Antagonists on Responses of Human
RT Monocyte-Derived Dendritic Cells to RNA Virus Infection.";
RL J. Virol. 90:5108-5118(2016).
RN [8] {ECO:0007744|PDB:4OR8}
RP X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS).
RX PubMed=24574400; DOI=10.1128/jvi.03565-13;
RA Zhang A.P., Bornholdt Z.A., Abelson D.M., Saphire E.O.;
RT "Crystal structure of Marburg virus VP24.";
RL J. Virol. 88:5859-5863(2014).
CC -!- FUNCTION: May act as a minor matrix protein that plays a role in
CC assembly of viral nucleocapsid and virion budding (PubMed:16227263).
CC Unlike Ebola VP24, mVP24 has no measurable impact of host dendritic
CC cell function (PubMed:26962215). {ECO:0000269|PubMed:16227263,
CC ECO:0000269|PubMed:26962215}.
CC -!- SUBUNIT: Monomer or homotetramer (Potential). Interacts with
CC nucleoprotein. {ECO:0000269|PubMed:16227263, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000269|PubMed:16227263};
CC Peripheral membrane protein {ECO:0000269|PubMed:16227263}. Host cell
CC membrane {ECO:0000269|PubMed:16227263}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16227263}; Cytoplasmic side
CC {ECO:0000269|PubMed:16227263}. Host endomembrane system
CC {ECO:0000269|PubMed:16227263}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16227263}. Note=In virion, localizes on the
CC intravirional side of the membrane. In the host cell, it is found
CC associated with virus-induced membrane proliferation foci and to the
CC plasma membrane where budding takes place.
CC -!- SIMILARITY: Belongs to the filoviridae membrane-associated protein VP24
CC family. {ECO:0000305}.
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DR EMBL; Z12132; CAA78119.1; -; mRNA.
DR EMBL; AY430365; AAR85465.1; -; Genomic_RNA.
DR EMBL; AY430366; AAR85458.1; -; Genomic_RNA.
DR EMBL; DQ217792; ABA87129.1; -; Genomic_RNA.
DR RefSeq; YP_001531158.1; NC_001608.3.
DR PDB; 4OR8; X-ray; 2.65 A; A/B=1-253.
DR PDBsum; 4OR8; -.
DR SMR; P35256; -.
DR IntAct; P35256; 23.
DR DNASU; 920943; -.
DR GeneID; 920943; -.
DR KEGG; vg:920943; -.
DR Proteomes; UP000007771; Genome.
DR Proteomes; UP000137266; Genome.
DR Proteomes; UP000160614; Genome.
DR Proteomes; UP000180448; Genome.
DR GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019013; C:viral nucleocapsid; IDA:CACAO.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR GO; GO:0016032; P:viral process; IEA:InterPro.
DR InterPro; IPR009433; Filo_VP24.
DR Pfam; PF06389; Filo_VP24; 1.
DR PIRSF; PIRSF011355; VP24; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Host cell membrane; Host membrane; Membrane;
KW Reference proteome; Viral matrix protein; Virion.
FT CHAIN 1..253
FT /note="Membrane-associated protein VP24"
FT /id="PRO_0000222156"
FT STRAND 3..5
FT /evidence="ECO:0007829|PDB:4OR8"
FT TURN 24..26
FT /evidence="ECO:0007829|PDB:4OR8"
FT STRAND 31..34
FT /evidence="ECO:0007829|PDB:4OR8"
FT STRAND 37..42
FT /evidence="ECO:0007829|PDB:4OR8"
FT STRAND 45..51
FT /evidence="ECO:0007829|PDB:4OR8"
FT HELIX 54..62
FT /evidence="ECO:0007829|PDB:4OR8"
FT HELIX 67..69
FT /evidence="ECO:0007829|PDB:4OR8"
FT HELIX 70..75
FT /evidence="ECO:0007829|PDB:4OR8"
FT HELIX 77..80
FT /evidence="ECO:0007829|PDB:4OR8"
FT STRAND 85..87
FT /evidence="ECO:0007829|PDB:4OR8"
FT HELIX 90..101
FT /evidence="ECO:0007829|PDB:4OR8"
FT HELIX 105..108
FT /evidence="ECO:0007829|PDB:4OR8"
FT HELIX 113..128
FT /evidence="ECO:0007829|PDB:4OR8"
FT TURN 138..140
FT /evidence="ECO:0007829|PDB:4OR8"
FT HELIX 147..164
FT /evidence="ECO:0007829|PDB:4OR8"
FT STRAND 178..183
FT /evidence="ECO:0007829|PDB:4OR8"
FT STRAND 186..193
FT /evidence="ECO:0007829|PDB:4OR8"
FT STRAND 196..203
FT /evidence="ECO:0007829|PDB:4OR8"
FT STRAND 205..207
FT /evidence="ECO:0007829|PDB:4OR8"
FT STRAND 218..225
FT /evidence="ECO:0007829|PDB:4OR8"
FT HELIX 226..230
FT /evidence="ECO:0007829|PDB:4OR8"
FT TURN 231..233
FT /evidence="ECO:0007829|PDB:4OR8"
FT STRAND 234..236
FT /evidence="ECO:0007829|PDB:4OR8"
SQ SEQUENCE 253 AA; 28636 MW; CFD6F1FAE99E0EE1 CRC64;
MAELSTRYNL PANVTENSIN LDLNSTARWI KEPSVGGWTV KWGNFVFHIP NTGMTLLHHL
KSNFVVPEWQ QTRNLFSHLF KNPKSTIIEP FLALRILLGV ALKDQELQQS LIPGFRSIVH
MLSEWLLLEV TSAIHISPNL LGIYLTSDMF KILMAGVKNF FNKMFTLHVV NDHGKPSSIE
IKLTGQQIII TRVNMGFLVE VRRIDIEPCC GETVLSESVV FGLVAEAVLR EHSQMEKGQP
LNLTQYMNSK IAI
