ID   VP24_MABVO              Reviewed;         253 AA.
AC   Q6UY64;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Membrane-associated protein VP24;
DE   AltName: Full=Marburg VP24;
DE            Short=mVP24;
GN   Name=VP24;
OS   Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain
OS   South Africa/Ozolin/1975)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Filoviridae; Marburgvirus.
OX   NCBI_TaxID=482820;
OH   NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9407; Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Bowen M.D., Thurman K., Minor E., Ibrahim M.S., Meyer R.F., Malfatti S.A.,
RA   Do L.H., Smith K.L., McCready P.M., Chain P.S.G.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a minor matrix protein that plays a role in
CC       assembly of viral nucleocapsid and virion budding. Unlike Ebola VP24,
CC       mVP24 has no measurable impact of host dendritic cell function.
CC       {ECO:0000250|UniProtKB:P35256}.
CC   -!- SUBUNIT: Monomer or homotetramer (Potential). Interacts with the
CC       nucleoprotein (By similarity). {ECO:0000250, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Host cell membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}. Host endomembrane system {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Note=In virion, localizes on the
CC       intravirional side of the membrane. In the host cell, it is found
CC       associated with virus-induced membrane proliferation foci and to the
CC       plasma membrane where budding takes place (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the filoviridae membrane-associated protein VP24
CC       family. {ECO:0000305}.
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DR   EMBL; AY358025; AAQ55260.1; -; Genomic_RNA.
DR   SMR; Q6UY64; -.
DR   Proteomes; UP000000838; Genome.
DR   GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR009433; Filo_VP24.
DR   Pfam; PF06389; Filo_VP24; 1.
DR   PIRSF; PIRSF011355; VP24; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host membrane; Membrane; Reference proteome;
KW   Viral matrix protein; Virion.
FT   CHAIN           1..253
FT                   /note="Membrane-associated protein VP24"
FT                   /id="PRO_0000314990"
SQ   SEQUENCE   253 AA;  28665 MW;  8FC2B9975E552240 CRC64;
     MAELSTRYNL PANVTEKSIN LDLNSTARWI KEPSVGGWTV KWGNFVFHIP NTGMTLLHHL
     KSNFVVPEWQ QTRNLFSHLF KNPKSTIIEP FLALRILLGV ALKDQELQQS LIPGFRSIVH
     MLSEWLLLEV TSAIHISPNL LGIYLTSDMF KILMAGVKNF FNKMFTLHVV NDHGKPSSIE
     IKLTGQQIII TRVNMGFLVE VRRIDIEPCC GETILSESVV FGLVAEAVLR EHSQMEKGQP
     LNLTQYMNSK IAI