ID   VP24_MABVP              Reviewed;         253 AA.
AC   P41325;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Membrane-associated protein VP24;
DE   AltName: Full=Marburg VP24;
DE            Short=mVP24;
GN   Name=VP24;
OS   Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain
OS   West Germany/Popp/1967)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Filoviridae; Marburgvirus.
OX   NCBI_TaxID=33728;
OH   NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9407; Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7773195;
RA   Bukreyev A.A., Belanov E.F., Blinov V.M., Netesov S.V.;
RT   "Complete nucleotide sequences of Marburg virus genes 5 and 6 encoding VP30
RT   and VP24 proteins.";
RL   Biochem. Mol. Biol. Int. 35:605-613(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7487490; DOI=10.1007/bf01322532;
RA   Bukreyev A.A., Volchkov V.E., Blinov V.M., Dryga S.A., Netesov S.V.;
RT   "The complete nucleotide sequence of the Popp (1967) strain of Marburg
RT   virus: a comparison with the Musoke (1980) strain.";
RL   Arch. Virol. 140:1589-1600(1995).
CC   -!- FUNCTION: May act as a minor matrix protein that plays a role in
CC       assembly of viral nucleocapsid and virion budding. Unlike Ebola VP24,
CC       mVP24 has no measurable impact of host dendritic cell function.
CC       {ECO:0000250|UniProtKB:P35256}.
CC   -!- SUBUNIT: Monomer or homotetramer (Potential). Interacts with
CC       nucleoprotein (By similarity). {ECO:0000250, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Host cell membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}. Host endomembrane system {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}. Note=In virion, localizes on the
CC       intravirional side of the membrane. In the host cell, it is found
CC       associated with virus-induced membrane proliferation foci and to the
CC       plasma membrane where budding takes place (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the filoviridae membrane-associated protein VP24
CC       family. {ECO:0000305}.
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DR   EMBL; X64405; CAA45747.1; -; Genomic_RNA.
DR   EMBL; Z29337; CAA82541.1; -; Genomic_RNA.
DR   PIR; S44053; S44053.
DR   SMR; P41325; -.
DR   Proteomes; UP000007772; Genome.
DR   GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR009433; Filo_VP24.
DR   Pfam; PF06389; Filo_VP24; 1.
DR   PIRSF; PIRSF011355; VP24; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host membrane; Membrane; Viral matrix protein; Virion.
FT   CHAIN           1..253
FT                   /note="Membrane-associated protein VP24"
FT                   /id="PRO_0000222157"
SQ   SEQUENCE   253 AA;  28621 MW;  3D7B903F4D452F3E CRC64;
     MAELSTRYNL PANVTEKSIN LDLNSTARWI KEPSVGGWTV KWGNFVFHIP NTGMALLHHL
     KSNFVVPEWQ QTRNLFSHLF KNPKSTIIEP FLALRILLGV ALKDQELQQS LIPGFRSIVH
     MLSEWLLLEV TSAIHISPNL LGIYLTSDMF KILMAGVKNF FNKMFTLHVV NDHGKPSSIE
     IKLTGQQIII TRVNMGFLVE VRRIDIEPCC GETVLSESVV FGLVAEAVLR EHSQMEKGQP
     LDLTQYMNSK IAI