VP26A_ARATH
ID VP26A_ARATH Reviewed; 302 AA.
AC Q9FJD0;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Vacuolar protein sorting-associated protein 26A;
DE AltName: Full=Vesicle protein sorting 26A;
GN Name=VPS26A; OrderedLocusNames=At5g53530; ORFNames=MNC6.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP COMPONENT OF THE RETROMER COMPLEX, AND SUBCELLULAR LOCATION.
RX PubMed=16582012; DOI=10.1105/tpc.105.035907;
RA Oliviusson P., Heinzerling O., Hillmer S., Hinz G., Tse Y.C., Jiang L.,
RA Robinson D.G.;
RT "Plant retromer, localized to the prevacuolar compartment and microvesicles
RT in Arabidopsis, may interact with vacuolar sorting receptors.";
RL Plant Cell 18:1239-1252(2006).
CC -!- FUNCTION: Plays a role in vesicular protein sorting. Component of the
CC membrane-associated retromer complex which is essential in endosome-to-
CC Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be
CC involved in recycling of specific cargos from endosome to the plasma
CC membrane.
CC -!- SUBUNIT: Component of the retromer complex which consists of VPS29
CC (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or VPS35B or VPS35C),
CC VPS5/17 (SNX1 or SNX2A or SNX2B). Component of a retromer subcomplex
CC consisting of VPS29 (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or
CC VPS35B or VPS35C).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16582012}. Endosome
CC membrane {ECO:0000269|PubMed:16582012}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16582012}; Cytoplasmic side
CC {ECO:0000269|PubMed:16582012}. Prevacuolar compartment membrane
CC {ECO:0000269|PubMed:16582012}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16582012}; Cytoplasmic side
CC {ECO:0000269|PubMed:16582012}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
CC Cytoplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
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DR EMBL; AB015476; BAB09729.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96373.1; -; Genomic_DNA.
DR EMBL; AK227917; BAE99887.1; -; mRNA.
DR RefSeq; NP_200165.1; NM_124733.4.
DR AlphaFoldDB; Q9FJD0; -.
DR SMR; Q9FJD0; -.
DR BioGRID; 20679; 5.
DR IntAct; Q9FJD0; 2.
DR STRING; 3702.AT5G53530.1; -.
DR PaxDb; Q9FJD0; -.
DR PRIDE; Q9FJD0; -.
DR ProteomicsDB; 242621; -.
DR EnsemblPlants; AT5G53530.1; AT5G53530.1; AT5G53530.
DR GeneID; 835435; -.
DR Gramene; AT5G53530.1; AT5G53530.1; AT5G53530.
DR KEGG; ath:AT5G53530; -.
DR Araport; AT5G53530; -.
DR TAIR; locus:2168636; AT5G53530.
DR eggNOG; KOG3063; Eukaryota.
DR HOGENOM; CLU_031077_3_1_1; -.
DR InParanoid; Q9FJD0; -.
DR OMA; LWVHSYR; -.
DR OrthoDB; 987411at2759; -.
DR PhylomeDB; Q9FJD0; -.
DR PRO; PR:Q9FJD0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FJD0; baseline and differential.
DR Genevisible; Q9FJD0; AT.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:TAIR.
DR GO; GO:0016020; C:membrane; IDA:TAIR.
DR GO; GO:0005771; C:multivesicular body; IDA:TAIR.
DR GO; GO:0030904; C:retromer complex; IDA:TAIR.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR Gene3D; 2.60.40.640; -; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR028934; Vps26-related.
DR PANTHER; PTHR12233; PTHR12233; 1.
DR Pfam; PF03643; Vps26; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Endosome; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..302
FT /note="Vacuolar protein sorting-associated protein 26A"
FT /id="PRO_0000414722"
SQ SEQUENCE 302 AA; 35150 MW; A01EC18CC4B7FB5C CRC64;
MNYLLGAFKP ACNISITFTD GKNRKQVPTK KDNGQIVMNP LFQSQETIAG KINIEPYQGK
KVEHNGVKVE LLGQIEMYFD RGNFYDFTSL VREIDVPGEI YERKTYPFEF SSVEMPYETY
NGVNVRLRYV LKVTVTRGYA GSIVEYQDFV VRNYVPLPPI NNSIKMEVGI EDCLHIEFEY
NKSKYHLKDV ILGKIYFLLV RIKIKNMDLE IRRRESTGAG ANTHVETETL AKFELMDGAP
VRGESIPVRV FLTPYDLTPT HKNINNKFSV KYYLNLVLVD EEDRRYFKQQ EITLYRLKEE
TS
