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VP26A_BOVIN
ID   VP26A_BOVIN             Reviewed;         327 AA.
AC   Q0VD53; A5D9A4;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Vacuolar protein sorting-associated protein 26A;
DE   AltName: Full=Vesicle protein sorting 26A;
GN   Name=VPS26A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as component of the retromer cargo-selective complex
CC       (CSC). The CSC is believed to be the core functional component of
CC       retromer or respective retromer complex variants acting to prevent
CC       missorting of selected transmembrane cargo proteins into the lysosomal
CC       degradation pathway. The recruitment of the CSC to the endosomal
CC       membrane involves RAB7A and SNX3.The SNX-BAR retromer mediates
CC       retrograde transport of cargo proteins from endosomes to the trans-
CC       Golgi network (TGN) and is involved in endosome-to-plasma membrane
CC       transport for cargo protein recycling. The SNX3-retromer mediates the
CC       retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR
CC       retromer pathway. The SNX27-retromer is believed to be involved in
CC       endosome-to-plasma membrane trafficking and recycling of a broad
CC       spectrum of cargo proteins. The CSC complex seems to act as recruitment
CC       hub for other proteins, such as the WASH complex and TBC1D5. Required
CC       for retrograde transport of lysosomal enzyme receptor IGF2R. Required
CC       to regulate transcytosis of the polymeric immunoglobulin receptor
CC       (pIgR-pIgA). Required for the endosomal localization of WASHC2
CC       (indicative for the WASH complex). Required for the endosomal
CC       localization of TBC1D5. Mediates retromer cargo recognition of SORL1
CC       and is involved in trafficking of SORL1 implicated in sorting and
CC       processing of APP. Involved in retromer-independent lysosomal sorting
CC       of F2R. Involved in recycling of ADRB2. Acts redundantly with VSP26B in
CC       SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. Enhances the
CC       affinity of SNX27 for PDZ-binding motifs in cargo proteins (By
CC       similarity). {ECO:0000250|UniProtKB:O75436,
CC       ECO:0000250|UniProtKB:P40336}.
CC   -!- SUBUNIT: Component of the heterotrimeric retromer cargo-selective
CC       complex (CSC), also described as vacuolar protein sorting subcomplex
CC       (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35. The CSC has
CC       a highly elongated structure with VPS26 and VPS29 binding independently
CC       at opposite distal ends of VPS35 as central platform. The CSC is
CC       believed to associate with variable sorting nexins to form functionally
CC       distinct retromer complex variants. The originally described retromer
CC       complex (also called SNX-BAR retromer) is a pentamer containing the CSC
CC       and a heterodimeric membrane-deforming subcomplex formed between SNX1
CC       or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the
CC       respective CSC and SNX-BAR subcomplexes associate with low affinity.
CC       The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC
CC       associates with SNX27, the WASH complex and the SNX-BAR subcomplex to
CC       form the SNX27-retromer complex. Interacts with VPS29, VPS35, SNX27,
CC       SNX1, SNX2, SNX5, SNX6, SNX3, RAB7A, ECPAS, EHD1, WASHC5, SORL1 (By
CC       similarity). {ECO:0000250|UniProtKB:O75436,
CC       ECO:0000250|UniProtKB:P40336}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40336}.
CC       Endosome membrane {ECO:0000250|UniProtKB:P40336}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:P40336}. Early endosome
CC       {ECO:0000250|UniProtKB:O75436}. Note=Localizes to tubular profiles
CC       adjacent to endosomes. Predominantly found in early not late endosomes.
CC       {ECO:0000250|UniProtKB:O75436}.
CC   -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
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DR   EMBL; BT030523; ABQ12963.1; -; mRNA.
DR   EMBL; BC119831; AAI19832.1; -; mRNA.
DR   RefSeq; NP_001068923.1; NM_001075455.1.
DR   AlphaFoldDB; Q0VD53; -.
DR   SMR; Q0VD53; -.
DR   STRING; 9913.ENSBTAP00000022455; -.
DR   PaxDb; Q0VD53; -.
DR   PeptideAtlas; Q0VD53; -.
DR   PRIDE; Q0VD53; -.
DR   Ensembl; ENSBTAT00000022455; ENSBTAP00000022455; ENSBTAG00000016882.
DR   GeneID; 510574; -.
DR   KEGG; bta:510574; -.
DR   CTD; 9559; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016882; -.
DR   VGNC; VGNC:36814; VPS26A.
DR   eggNOG; KOG3063; Eukaryota.
DR   GeneTree; ENSGT00950000183064; -.
DR   HOGENOM; CLU_031077_0_0_1; -.
DR   InParanoid; Q0VD53; -.
DR   OMA; FKQHGKR; -.
DR   OrthoDB; 987411at2759; -.
DR   TreeFam; TF300907; -.
DR   Reactome; R-BTA-3238698; WNT ligand biogenesis and trafficking.
DR   Proteomes; UP000009136; Chromosome 28.
DR   Bgee; ENSBTAG00000016882; Expressed in spermatid and 107 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0030904; C:retromer complex; IBA:GO_Central.
DR   GO; GO:0030906; C:retromer, cargo-selective complex; IEA:Ensembl.
DR   GO; GO:0097422; C:tubular endosome; ISS:UniProtKB.
DR   GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR   GO; GO:0032456; P:endocytic recycling; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISS:UniProtKB.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR028934; Vps26-related.
DR   PANTHER; PTHR12233; PTHR12233; 1.
DR   Pfam; PF03643; Vps26; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Membrane; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..327
FT                   /note="Vacuolar protein sorting-associated protein 26A"
FT                   /id="PRO_0000283790"
FT   REGION          306..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        312..327
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         315
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75436"
SQ   SEQUENCE   327 AA;  38156 MW;  AA982903526CB231 CRC64;
     MSFLGGFFGP ICEIDVVLND GETRKMAEMK TEDGKVEKHY LFYDGESVSG KVNLAFKQPG
     KRLEHQGIRI EFVGQIELFN DKSNTHEFVN LVKELALPGE LTQSRSYDFE FMQVEKPYES
     YIGANVRLRY FLKVTIVRRL TDLVKEYDLI VHQLATYPDV NNSIKMEVGI EDCLHIEFEY
     NKSKYHLKDV IVGKIYFLLV RIKIQHMELQ LIKKEITGIG PSTTTETETI AKYEIMDGAP
     VKGESIPIRL FLAGYDPTPT MRDVNKKFSV RYFLNLVLVD EEDRRYFKQQ EIILWRKAPE
     KLRKQRTNFH QRFESPESQA SAEQPEM
 
 
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