VP26B_ARATH
ID VP26B_ARATH Reviewed; 303 AA.
AC Q9T091; Q8L3V2;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2002, sequence version 2.
DT 25-MAY-2022, entry version 140.
DE RecName: Full=Vacuolar protein sorting-associated protein 26B;
DE AltName: Full=Vesicle protein sorting 26B;
GN Name=VPS26B; OrderedLocusNames=At4g27690; ORFNames=T29A15.180;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP COMPONENT OF THE RETROMER COMPLEX, AND SUBCELLULAR LOCATION.
RX PubMed=16582012; DOI=10.1105/tpc.105.035907;
RA Oliviusson P., Heinzerling O., Hillmer S., Hinz G., Tse Y.C., Jiang L.,
RA Robinson D.G.;
RT "Plant retromer, localized to the prevacuolar compartment and microvesicles
RT in Arabidopsis, may interact with vacuolar sorting receptors.";
RL Plant Cell 18:1239-1252(2006).
CC -!- FUNCTION: Plays a role in vesicular protein sorting. Component of the
CC membrane-associated retromer complex which is essential in endosome-to-
CC Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be
CC involved in recycling of specific cargos from endosome to the plasma
CC membrane.
CC -!- SUBUNIT: Component of the retromer complex which consists of VPS29
CC (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or VPS35B or VPS35C),
CC VPS5/17 (SNX1 or SNX2A or SNX2B). Component of a retromer subcomplex
CC consisting of VPS29 (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or
CC VPS35B or VPS35C).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16582012}. Endosome
CC membrane {ECO:0000269|PubMed:16582012}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16582012}; Cytoplasmic side
CC {ECO:0000269|PubMed:16582012}. Prevacuolar compartment membrane
CC {ECO:0000269|PubMed:16582012}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16582012}; Cytoplasmic side
CC {ECO:0000269|PubMed:16582012}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
CC Cytoplasmic side {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9T091-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB38281.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB81419.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL035602; CAB38281.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161571; CAB81419.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85381.1; -; Genomic_DNA.
DR EMBL; AY094409; AAM19785.1; -; mRNA.
DR EMBL; AY122891; AAM67424.1; -; mRNA.
DR PIR; A85322; A85322.
DR PIR; T05874; T05874.
DR RefSeq; NP_194499.2; NM_118908.5. [Q9T091-1]
DR AlphaFoldDB; Q9T091; -.
DR SMR; Q9T091; -.
DR BioGRID; 14170; 6.
DR IntAct; Q9T091; 1.
DR STRING; 3702.AT4G27690.1; -.
DR PaxDb; Q9T091; -.
DR PRIDE; Q9T091; -.
DR ProteomicsDB; 242731; -. [Q9T091-1]
DR DNASU; 828883; -.
DR EnsemblPlants; AT4G27690.1; AT4G27690.1; AT4G27690. [Q9T091-1]
DR GeneID; 828883; -.
DR Gramene; AT4G27690.1; AT4G27690.1; AT4G27690. [Q9T091-1]
DR KEGG; ath:AT4G27690; -.
DR Araport; AT4G27690; -.
DR TAIR; locus:2137787; AT4G27690.
DR eggNOG; KOG3063; Eukaryota.
DR HOGENOM; CLU_031077_3_1_1; -.
DR InParanoid; Q9T091; -.
DR OMA; HQHVPLH; -.
DR PhylomeDB; Q9T091; -.
DR PRO; PR:Q9T091; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9T091; baseline and differential.
DR Genevisible; Q9T091; AT.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030904; C:retromer complex; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR Gene3D; 2.60.40.640; -; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR028934; Vps26-related.
DR PANTHER; PTHR12233; PTHR12233; 1.
DR Pfam; PF03643; Vps26; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Endosome; Golgi apparatus; Membrane;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..303
FT /note="Vacuolar protein sorting-associated protein 26B"
FT /id="PRO_0000073013"
SQ SEQUENCE 303 AA; 35204 MW; E64F75D02D932819 CRC64;
MNYLLGAFKP ACNISITFSD GKNRKQVPMK KENGQTALVP LFHSQDTISG KVCIEPYQGK
KVEHNGVKVE LLGQIEMYFD RGNFYDFTSL VRELDVPGEI YERKTYPFEF PTVEMPYETY
NGVNVRLRYV LKVTVTRGYA GSILEYQELV VRNYAPLPDI NNSIKMEVGI EDCLHIEFEY
NKSKYHLKDV ILGKIYFLLV RIKMKNMDLE IRRRESTGAG ANTHVETETL AKFELMDGTP
VRGESIPVRL FLAPYDLTPT HRNINNKFSV KYYLNLVLVD EEDRRYFKQQ EITLYRLKED
ASS
