ID   VP26B_DANRE             Reviewed;         331 AA.
AC   Q7ZV03;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Vacuolar protein sorting-associated protein 26B;
DE   AltName: Full=Vesicle protein sorting 26B;
GN   Name=vps26b; ORFNames=zgc:56297;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as component of the retromer cargo-selective complex
CC       (CSC). The CSC is believed to be the core functional component of
CC       retromer or respective retromer complex variants acting to prevent
CC       missorting of selected transmembrane cargo proteins into the lysosomal
CC       degradation pathway. Retromer mediates retrograde transport of cargo
CC       proteins from endosomes to the trans-Golgi network (TGN) (By
CC       similarity). {ECO:0000250|UniProtKB:Q8C0E2}.
CC   -!- SUBUNIT: Component of the heterotrimeric retromer cargo-selective
CC       complex (CSC) which is believed to associate with variable sorting
CC       nexins to form functionally distinct retromer complex variants (By
CC       similarity). {ECO:0000250|UniProtKB:Q8C0E2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8C0E2}.
CC       Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8C0E2}.
CC       Endosome {ECO:0000250|UniProtKB:Q8C0E2}.
CC   -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
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DR   EMBL; BC046056; AAH46056.1; -; mRNA.
DR   RefSeq; NP_998540.1; NM_213375.1.
DR   AlphaFoldDB; Q7ZV03; -.
DR   SMR; Q7ZV03; -.
DR   STRING; 7955.ENSDARP00000020396; -.
DR   PaxDb; Q7ZV03; -.
DR   PRIDE; Q7ZV03; -.
DR   DNASU; 406684; -.
DR   Ensembl; ENSDART00000022015; ENSDARP00000020396; ENSDARG00000015823.
DR   GeneID; 406684; -.
DR   KEGG; dre:406684; -.
DR   CTD; 112936; -.
DR   ZFIN; ZDB-GENE-040426-2699; vps26b.
DR   eggNOG; KOG3063; Eukaryota.
DR   GeneTree; ENSGT00950000183064; -.
DR   HOGENOM; CLU_031077_0_0_1; -.
DR   InParanoid; Q7ZV03; -.
DR   OMA; HSQENIA; -.
DR   OrthoDB; 987411at2759; -.
DR   PhylomeDB; Q7ZV03; -.
DR   TreeFam; TF300907; -.
DR   PRO; PR:Q7ZV03; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 15.
DR   Bgee; ENSDARG00000015823; Expressed in granulocyte and 28 other tissues.
DR   ExpressionAtlas; Q7ZV03; baseline.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0030904; C:retromer complex; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR028934; Vps26-related.
DR   PANTHER; PTHR12233; PTHR12233; 1.
DR   Pfam; PF03643; Vps26; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..331
FT                   /note="Vacuolar protein sorting-associated protein 26B"
FT                   /id="PRO_0000247092"
FT   REGION          310..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   331 AA;  38627 MW;  6D396132E28949BE CRC64;
     MSFFGFGQTA EIDIVLNDAE TRKKVEHKTE DGKKDKYFLF YDGETVSGKV NVTLKTPGKR
     LEHYGIKIEF VGQIELYYDR GNHHEFVSLV KDLARPGELS QSQTFDFEFT HVEKPYESYT
     GQNVKLRYFL RATISRRLND ISKEMDIVVQ TLCTYPEINS SIKMEVGIED CLHIEFEYNK
     SKYHLRDVIV GKIYFLLVRI KIKHMEIDII KRETTGTGPS VYHENDTIAK YEIMDGAPVR
     GESIPIRLFL AGYEMTPTMR DINKKFSVRY YLNLVLIDEE ERRYFKQQEI TLWRKGDIVR
     RSMSQQATIA AQRYEGSNPE PTSAQAKEET D