ID   VP26B_XENTR             Reviewed;         337 AA.
AC   Q5BKM4;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Vacuolar protein sorting-associated protein 26B;
DE   AltName: Full=Vesicle protein sorting 26B;
GN   Name=vps26b; ORFNames=TTpA009m02.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as component of the retromer cargo-selective complex
CC       (CSC). The CSC is believed to be the core functional component of
CC       retromer or respective retromer complex variants acting to prevent
CC       missorting of selected transmembrane cargo proteins into the lysosomal
CC       degradation pathway. Retromer mediates retrograde transport of cargo
CC       proteins from endosomes to the trans-Golgi network (TGN) (By
CC       similarity). {ECO:0000250|UniProtKB:Q8C0E2}.
CC   -!- SUBUNIT: Component of the heterotrimeric retromer cargo-selective
CC       complex (CSC) which is believed to associate with variable sorting
CC       nexins to form functionally distinct retromer complex variants (By
CC       similarity). {ECO:0000250|UniProtKB:Q8C0E2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8C0E2}.
CC       Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8C0E2}.
CC       Endosome {ECO:0000250|UniProtKB:Q8C0E2}.
CC   -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
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DR   EMBL; CR760763; CAJ83153.1; -; mRNA.
DR   EMBL; BC091021; AAH91021.1; -; mRNA.
DR   RefSeq; NP_001016540.1; NM_001016540.2.
DR   AlphaFoldDB; Q5BKM4; -.
DR   SMR; Q5BKM4; -.
DR   STRING; 8364.ENSXETP00000018272; -.
DR   PaxDb; Q5BKM4; -.
DR   DNASU; 549294; -.
DR   Ensembl; ENSXETT00000018272; ENSXETP00000018272; ENSXETG00000008335.
DR   GeneID; 549294; -.
DR   KEGG; xtr:549294; -.
DR   CTD; 112936; -.
DR   Xenbase; XB-GENE-945593; vps26b.
DR   eggNOG; KOG3063; Eukaryota.
DR   HOGENOM; CLU_031077_0_0_1; -.
DR   InParanoid; Q5BKM4; -.
DR   OMA; LWVHSYR; -.
DR   OrthoDB; 987411at2759; -.
DR   PhylomeDB; Q5BKM4; -.
DR   TreeFam; TF300907; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008335; Expressed in brain and 13 other tissues.
DR   ExpressionAtlas; Q5BKM4; baseline.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0030904; C:retromer complex; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR028934; Vps26-related.
DR   PANTHER; PTHR12233; PTHR12233; 1.
DR   Pfam; PF03643; Vps26; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..337
FT                   /note="Vacuolar protein sorting-associated protein 26B"
FT                   /id="PRO_0000247096"
FT   REGION          311..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   337 AA;  39194 MW;  3058F50E3BCF9641 CRC64;
     MSFFGFGPAA ELDIALTDGE SRRRVEHKTE DGKKEKYFLF YDGETVSGRV TVNLRNPGKR
     LEHQGLKIEF IGQIELYYDR GNHHEFVSLV KDLARPGEIS QSQSFDFEFT HVEKPYESYT
     GQNVKLRYFL RATLSRRLND VVKEMDIVVH TLSTYPELNS SIKMEVGIED CLHIEFEYNK
     SKYHLKDVIV GKIYFLLVRI KIKHMEIDII KRETTGTGPN VYHENDTIAK YEIMDGAPVR
     GESIPIRLFL AGYELTPTMR DINKKFSVRY YLNLVLIDEE ERRYFKQQEV VLWRKGDIVR
     KSMSHQAAIA SQRFEGTSHP ETRPQHSGAA AVEQEQE