ID   VP26C_DICDI             Reviewed;         304 AA.
AC   Q54DI8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Vacuolar protein sorting-associated protein 26C {ECO:0000305};
DE   AltName: Full=Down syndrome critical region protein 3 homolog;
DE   AltName: Full=Vacuolar protein sorting-associated protein 26-like;
GN   Name=vps26c; ORFNames=DDB_G0292212;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May act as component of the retriever complex.
CC       {ECO:0000250|UniProtKB:O14972}.
CC   -!- SUBUNIT: Component of the heterotrimeric retriever complex.
CC       {ECO:0000250|UniProtKB:O14972}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:O14972}.
CC   -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
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DR   EMBL; AAFI02000188; EAL61316.1; -; Genomic_DNA.
DR   RefSeq; XP_629739.1; XM_629737.1.
DR   AlphaFoldDB; Q54DI8; -.
DR   SMR; Q54DI8; -.
DR   STRING; 44689.DDB0267115; -.
DR   PaxDb; Q54DI8; -.
DR   EnsemblProtists; EAL61316; EAL61316; DDB_G0292212.
DR   GeneID; 8628568; -.
DR   KEGG; ddi:DDB_G0292212; -.
DR   dictyBase; DDB_G0292212; vps26l.
DR   eggNOG; KOG2717; Eukaryota.
DR   HOGENOM; CLU_056829_0_0_1; -.
DR   InParanoid; Q54DI8; -.
DR   OMA; RCDIKRS; -.
DR   PhylomeDB; Q54DI8; -.
DR   PRO; PR:Q54DI8; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR028934; Vps26-related.
DR   PANTHER; PTHR12233; PTHR12233; 1.
DR   Pfam; PF03643; Vps26; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Endosome; Reference proteome.
FT   CHAIN           1..304
FT                   /note="Vacuolar protein sorting-associated protein 26C"
FT                   /id="PRO_0000328100"
SQ   SEQUENCE   304 AA;  33939 MW;  E6C7E9B5E9838DEF CRC64;
     MNNVLDLKLK KIDKIYRPGS KVSGNVVINS KDDMSHSGVT IVVEGTVQLQ LSSKSVGLFE
     AFYNSLKPIT LMHYTISVTN GGGKFQAGIT ELPFEFTLEP LPNQQLYDTY HGVFVNIQYS
     IKCDVKRGIL SKDLSKTIEF IVEVPSQNKE VLMKSTPESL ITFNITPDSL VNFKKISKAD
     VPTFKISGGL VSAICNINEA FQGHMIIESA DTVIKSVELQ LVRVETCGCA DGYAREVTEI
     QNIQIADGDI WRNFKIPLYM VFPRLFTCIS TAGKTFKIEF EVNLVIMLED GHLITENFPI
     KLIR