ID   VP26C_PONAB             Reviewed;         297 AA.
AC   Q5RF33;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Vacuolar protein sorting-associated protein 26C {ECO:0000305};
DE   AltName: Full=Down syndrome critical region protein 3 homolog;
GN   Name=VPS26C; Synonyms=DSCR3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as component of the retriever complex. The retriever
CC       complex is a heterotrimeric complex related to retromer cargo-selective
CC       complex (CSC) and essential for retromer-independent retrieval and
CC       recycling of numerous cargos such as integrin alpha-5/beta-1
CC       (ITGA5:ITGB1). The recruitment of the retriever complex to the
CC       endosomal membrane involves CCC and WASH complexes. In the endosomes,
CC       drives the retriever and recycling of NxxY-motif-containing cargo
CC       proteins by coupling to SNX17, a cargo essential for the homeostatic
CC       maintenance of numerous cell surface proteins associated with processes
CC       that include cell migration, cell adhesion, nutrient supply and cell
CC       signaling. {ECO:0000250|UniProtKB:O14972}.
CC   -!- SUBUNIT: Component of the heterotrimeric retriever complex formed by
CC       VPS26C, VPS29 and VPS35L. Interacts with SNX17; the interaction is
CC       direct and associates SNX17 with the retriever complex. Interacts with
CC       SNX31; the interaction is direct. {ECO:0000250|UniProtKB:O14972}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:O14972}.
CC   -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
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DR   EMBL; CR857328; CAH89624.1; -; mRNA.
DR   RefSeq; NP_001124728.1; NM_001131256.2.
DR   AlphaFoldDB; Q5RF33; -.
DR   SMR; Q5RF33; -.
DR   STRING; 9601.ENSPPYP00000012737; -.
DR   Ensembl; ENSPPYT00000038658; ENSPPYP00000044029; ENSPPYG00000040834.
DR   GeneID; 100171577; -.
DR   KEGG; pon:100171577; -.
DR   CTD; 10311; -.
DR   eggNOG; KOG2717; Eukaryota.
DR   GeneTree; ENSGT00950000183064; -.
DR   HOGENOM; CLU_056829_0_0_1; -.
DR   InParanoid; Q5RF33; -.
DR   OMA; RCDIKRS; -.
DR   OrthoDB; 1476901at2759; -.
DR   TreeFam; TF323199; -.
DR   Proteomes; UP000001595; Chromosome 21.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0032456; P:endocytic recycling; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR028934; Vps26-related.
DR   PANTHER; PTHR12233; PTHR12233; 1.
DR   Pfam; PF03643; Vps26; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Reference proteome.
FT   CHAIN           1..297
FT                   /note="Vacuolar protein sorting-associated protein 26C"
FT                   /id="PRO_0000073018"
SQ   SEQUENCE   297 AA;  33017 MW;  3088A119624115C4 CRC64;
     MGTALDIKIK RANKVYHAGE VLSGVVVISS KDSVQHQGVS LTMEGTVNLQ LSAKSVGVFE
     AFYNSVKPIQ IINSNIEMVK PGKFPSGKTE IPFEFPLHVK GNKVLYETYH GVFVNIQYTL
     RCDMKRSLLA KDLTKTCEFI VHSAPQKGKF SPSPVHFTIT PETLQNARER ALLPKFLLRG
     HLNSTNCVIT QPLTGELVVE SSEAAIRSVE LQLVRVETCG CAEGYARDAT EIQNIQIADG
     DVCRGLSVPI YMVFPRLFTC PTLETTNFKV EFEVNIVVLL HPDHLITENF PLKLCRI