ID   VP2_AHSV3               Reviewed;        1057 AA.
AC   Q89508;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Outer capsid protein VP2;
GN   Name=Segment-2; Synonyms=L2;
OS   African horse sickness virus 3 (AHSV-3).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=117204;
OH   NCBI_TaxID=8835; Anas (ducks).
OH   NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH   NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
OH   NCBI_TaxID=9796; Equus caballus (Horse).
OH   NCBI_TaxID=9794; Equus hemionus (Onager) (Asian wild ass).
OH   NCBI_TaxID=89252; Equus quagga burchellii (Plains zebra) (Equus burchelli).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7996157; DOI=10.1099/0022-1317-75-12-3629;
RA   Vreede F.T., Huismans H.;
RT   "Cloning, characterization and expression of the gene that encodes the
RT   major neutralization-specific antigen of African horsesickness virus
RT   serotype 3.";
RL   J. Gen. Virol. 75:3629-3633(1994).
CC   -!- FUNCTION: The VP2 protein is one of the two proteins (with VP5) which
CC       constitute the virus particle outer capsid. It is the major target of
CC       the host immunogenic response.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP2 family. {ECO:0000305}.
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DR   EMBL; U01832; AAA62184.1; -; Genomic_RNA.
DR   EMBL; Z26316; CAA81225.1; -; Genomic_DNA.
DR   PIR; S47151; S47151.
DR   PRIDE; Q89508; -.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001742; Capsid_VP2_Orbivir.
DR   Pfam; PF00898; Orbi_VP2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Inner capsid protein; Virion.
FT   CHAIN           1..1057
FT                   /note="Outer capsid protein VP2"
FT                   /id="PRO_0000222688"
SQ   SEQUENCE   1057 AA;  123064 MW;  2880D3DB091C06C4 CRC64;
     MASEFGILLT NQIYDQTYEK EMCDVIITAE NAVRRVEVAG VHGYEWGATN HRLGLCEVEN
     TKSIGRMIYE QIRCEGAYPI FPHYITDTLK YGKSIDRNDN QIRVDRDDER VRKIKIQPYF
     GEMYFSPENY ITVFCKRQAI SGQIEVSRSI IGRRMKYEES AEQTKGTINA NKYRLLEKWR
     DLAYEQIEIE RDNERCLTHN TDPIYQLIKK MRYGMMYPVH YMLNDRYKVV QERADMGVEK
     WLLQKIGRGT QRRKADDGDN DALLQLERMM SSEELERSVI ESVIRFGSLY NAHAGKKTGD
     IPLEVLIKYC DSLTTFVHKK NREGGDNQTA RDEIRRAVVK NIPSMKQENQ MKVTPNIRNF
     LFFAYLNGFK RNNGVDIDPN NGTWSKHKAE VKKFLNEEQK KNENKPLKVL IDGAYISTDA
     EYGTVAHWVD WVVDIVMMTQ VSRMIKEYNF IRLKKDQLIS GMNKLEDGVK CYAYCLILAL
     YDFHGRDVDG FAQGTRTAAI VETVARMFPD FRSEVSEKFG IDLAVSEESD ELFVKKTMVS
     SFSDSGEMGY KFIFGWRKTD FKVETDYGEI VSDEVHRLYQ AILDGKEWSK EVDDPEKYFV
     DDLYNRCPES IYVRNGVDPN NKIMIKKRGL VGESQRIFLR DLSHIGMNFK KLLLRLSSKR
     LHARGEHIQY HEIDVEDFKP CAIAELGLHC STYIYQDLLV GANRGEYVKD AKELVWFDIA
     NTNFNITRPF DRCWPSSCAE AELSLRFHLI TKIFTRYRGE RTSFVDIINE LSEHGYVKHN
     FPSYKHYYLS VIQTVFEDQR AIDPLDFCAM ISRNETREST LKGFSMFTAI VKSERLIDTL
     FLNFLLWIVF EMENVDVSAA NKRHPLLISH EKGLRLIGVD LFNGALSIST GGWIPYLERI
     CSEEKAQRRL NADELKIKSW FLTYYMNLSL ERRAEPRMSF KFEGLTTWIG SNCGGVRDYV
     VQALPMRKPK PGLLMIIYGD DGDARWVEWA MKNFTAVDGS LGFIYIDRHK LVNKSDFRVR
     EMKIYNRGRL DRLILISSGH YTFGNKFLMS KLLAKTE