VP2_AHSV4
ID VP2_AHSV4 Reviewed; 1060 AA.
AC P32553; Q64910; Q64925; Q64927;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Outer capsid protein VP2;
GN Name=Segment-2; Synonyms=L2;
OS African horse sickness virus 4 (AHSV-4).
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX NCBI_TaxID=36421;
OH NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
OH NCBI_TaxID=9796; Equus caballus (Horse).
OH NCBI_TaxID=9794; Equus hemionus (Onager) (Asian wild ass).
OH NCBI_TaxID=89252; Equus quagga burchellii (Plains zebra) (Equus burchelli).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Vaccine;
RX PubMed=1329319; DOI=10.1016/0042-6822(92)90187-t;
RA Iwata H., Yamagawa M., Roy P.;
RT "Evolutionary relationships among the gnat-transmitted orbiviruses that
RT cause African horse sickness, bluetongue, and epizootic hemorrhagic disease
RT as evidenced by their capsid protein sequences.";
RL Virology 191:251-261(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Vaccine;
RX PubMed=8075221; DOI=10.1292/jvms.56.321;
RA Sakamoto K., Mizukoshi N., Apiwatnakorn B., Iwata A., Tsuchiya T., Ueda S.,
RA Imagawa H., Sugiura T., Kamada M., Fukusho A.;
RT "The complete sequences of African horsesickness virus serotype 4 (vaccine
RT strain) RNA segment 2 and 6 which encode outer capsid protein.";
RL J. Vet. Med. Sci. 56:321-327(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Plum Island;
RA Stone-Marschat M.;
RL Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Vaccine;
RA Martinez Torrecuadrada J.L., Ranz A., Diez J., Martinez C., Sanz A.,
RA Casal J.I.;
RL Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The VP2 protein is one of the two proteins (with VP5) which
CC constitute the virus particle outer capsid. It is the major target of
CC the host immunogenic response.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the orbivirus VP2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M94680; AAA42537.1; -; Genomic_RNA.
DR EMBL; D26570; BAA05619.1; -; Genomic_RNA.
DR EMBL; U21956; AAA67288.1; -; Genomic_RNA.
DR EMBL; M90697; AAA42541.1; -; Genomic_RNA.
DR PIR; A36820; P2XRA4.
DR PIR; S27891; S27891.
DR GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR001742; Capsid_VP2_Orbivir.
DR Pfam; PF00898; Orbi_VP2; 1.
PE 3: Inferred from homology;
KW Capsid protein; Inner capsid protein; Virion.
FT CHAIN 1..1060
FT /note="Outer capsid protein VP2"
FT /id="PRO_0000222689"
FT CONFLICT 9..11
FT /note="MTN -> LTD (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 9
FT /note="M -> L (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 30
FT /note="K -> T (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 158
FT /note="Y -> F (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="K -> G (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="D -> N (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="V -> I (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="Q -> K (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 190
FT /note="I -> A (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="E -> Q (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 232..235
FT /note="PNKG -> QIR (in Ref. 4; AAA42541)"
FT /evidence="ECO:0000305"
FT CONFLICT 261
FT /note="K -> L (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="A -> S (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 304..305
FT /note="IE -> VD (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="A -> T (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 342
FT /note="G -> R (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 346
FT /note="M -> K (in Ref. 1; AAA42537)"
FT /evidence="ECO:0000305"
FT CONFLICT 357
FT /note="G -> R (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="R -> K (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 384
FT /note="G -> N (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 396
FT /note="K -> R (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 402
FT /note="T -> N (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 418
FT /note="V -> I (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 427
FT /note="V -> I (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 437
FT /note="I -> M (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 466
FT /note="S -> G (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 470
FT /note="V -> I (in Ref. 2; BAA05619 and 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 481..482
FT /note="AI -> PF (in Ref. 4; AAA42541)"
FT /evidence="ECO:0000305"
FT CONFLICT 489
FT /note="T -> I (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 499
FT /note="A -> C (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 555
FT /note="A -> T (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 583
FT /note="G -> S (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 587
FT /note="G -> E (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 602
FT /note="Y -> N (in Ref. 4; AAA42541)"
FT /evidence="ECO:0000305"
FT CONFLICT 652
FT /note="V -> I (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 662
FT /note="L -> P (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 681
FT /note="P -> H (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 691
FT /note="A -> T (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 715
FT /note="L -> I (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 730
FT /note="S -> P (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 766..769
FT /note="TFST -> AYSM (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 780
FT /note="K -> E (in Ref. 2; BAA05619 and 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 789..801
FT /note="HYYLETLQRVFND -> LIIWKLSNVSLTY (in Ref. 4;
FT AAA42541)"
FT /evidence="ECO:0000305"
FT CONFLICT 810
FT /note="F -> S (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 813
FT /note="R -> K (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 813
FT /note="R -> S (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 816
FT /note="D -> N (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 827
FT /note="F -> L (in Ref. 3; AAA67288)"
FT /evidence="ECO:0000305"
FT CONFLICT 831
FT /note="H -> Q (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 835
FT /note="E -> Q (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 864
FT /note="Y -> D (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 878
FT /note="R -> G (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
FT CONFLICT 935
FT /note="R -> A (in Ref. 4; AAA42541)"
FT /evidence="ECO:0000305"
FT CONFLICT 980
FT /note="V -> A (in Ref. 2; BAA05619)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1060 AA; 124061 MW; 31F53E6EAD7D12B6 CRC64;
MASEFGILMT NEKFDPSLEK TICDVIVTKK GRVKHKEVDG VCGYEWDETN HRFGLCEVEH
DMSISEFMYN EIRCEGAYPI FPRYIIDTLK YEKFIDRNDH QIRVDRDDNE MRKILIQPYA
GEMYFSPECY PSVFLRREAR SQKLDRIRNY IGKRVEFYEE ESKRKAILDQ NKMSKVEQWR
DAVNERIVSI EPKRGECYDH GTDIIYQFIK KLRFGMMYPH YYVLHSDYCI VPNKGGTSIG
SWHIRKRTEG DAKASAMYSG KGPLNDLRVK IERDDLSRET IIQIIEYGKK FNSSAGDKQG
NISIEKLVEY CDFLTTFVHA KKKEEGEDDT ARQEIRKAWV KGMPYMDFSK PMKITRGFNR
NMLFFAALDS FRKRNGVDVD PNKGKWKEHI KEVTEKLKKA QTENGGQPCQ VSIDGVNVLT
NVDYGTVNHW IDWVTDIIMV VQTKRLVKEY AFKKLKSENL LAGMNSLVGV LRCYMYCLAL
AIYDFYEGTI DGFKKGSNAS AIIETVAQMF PDFRRELVEK FGIDLRMKEI TRELFVGKSM
TSKFMEEGEY GYKFAYGWRR DGFAVMEDYG EILTEKVEDL YKGVLLGRKW EDEVDDPESY
FYDDLYTNEP HRVFLSAGKD VDNNITLRSI SQAETTYLSK RFVSYWYRIS QVEVTKARNE
VLDMNEKQKP YFEFEYDDFK PCSIGELGIH ASTYIYQNLL VGRNRGEEIL DSKELVWMDM
SLLNFGAVRS HDRCWISSSV AIEVNLRHAL IVRIFSRFDM MSERETFSTI LEKVMEDVKK
LRFFPTYRHY YLETLQRVFN DERRLEVDDF YMRLYDVQTR EQALNTFTDF HRCVESELLL
PTLKLNFLLW IVFEMENVEV NAAYKRHPLL ISTAKGLRVI GVDIFNSQLS ISMSGWIPYV
ERMCAESKVQ TKLTADELKL KRWFISYYTT LKLDRRAEPR MSFKFEGLST WIGSNCGGVR
DYVIQMLPTR KPKPGALMVV YARDSRIEWI EAELSQWLQM EGSLGLILVH DSGIINKSVL
RARTLKIYNR GSMDTLILIS SGVYTFGNKF LLSKLLAKTE
