ID   VP2_AHSV6               Reviewed;        1051 AA.
AC   O71024;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Outer capsid protein VP2;
GN   Name=Segment-2; Synonyms=L2;
OS   African horse sickness virus 6 (AHSV-6).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=86060;
OH   NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH   NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
OH   NCBI_TaxID=9796; Equus caballus (Horse).
OH   NCBI_TaxID=9794; Equus hemionus (Onager) (Asian wild ass).
OH   NCBI_TaxID=89252; Equus quagga burchellii (Plains zebra) (Equus burchelli).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9617769; DOI=10.1016/s0168-1702(97)00131-7;
RA   Williams C.F., Inoue T., Lucus A.-M., Zanotto P., Roy P.;
RT   "The complete sequence of four major structural proteins of African horse
RT   sickness virus serotype 6: evolutionary relationships within and between
RT   the orbiviruses.";
RL   Virus Res. 53:53-73(1998).
CC   -!- FUNCTION: The VP2 protein is one of the two proteins (with VP5) which
CC       constitute the virus particle outer capsid. It is the major target of
CC       the host immunogenic response.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP2 family. {ECO:0000305}.
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DR   EMBL; AF021235; AAC40994.1; -; mRNA.
DR   RefSeq; YP_052941.1; NC_005996.1.
DR   PRIDE; O71024; -.
DR   GeneID; 2930875; -.
DR   KEGG; vg:2930875; -.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001742; Capsid_VP2_Orbivir.
DR   Pfam; PF00898; Orbi_VP2; 1.
PE   2: Evidence at transcript level;
KW   Capsid protein; Inner capsid protein; Virion.
FT   CHAIN           1..1051
FT                   /note="Outer capsid protein VP2"
FT                   /id="PRO_0000222690"
SQ   SEQUENCE   1051 AA;  122327 MW;  2B04DB9E389F4B5F CRC64;
     MASEFGILIC DKLKENTLEK TNCDVIITGV GKVGVHEEDG VLGYEWEETN YRLGLCEIEN
     TMSISDFVYK QIRCEGAYPI LPHYVTDVIK YGMVIHRNDH QIRVDRDEKS IGKIQIQPYF
     GDMYFSPEYY PATFIKRESL PISVDTIRGY IGARMRGIEA RAGRIREGDG NLLECARRWE
     KAAYERIENE KALRCVAHET DPTYQILKKQ RFGFVYPHYY VLNTNYNPTT VTRTSRINDW
     LLKEKTQGVV KTAEAFSDNA ELKTLAERME EEELTEDIIR AVIRYGAKYA TRSGMREDTL
     SLQELDRYCD SLTTFVHKKK KDEGDDETAR TIIRNQWIKG MPRMDFKKEM KITRGPIANW
     SFFMSIDAFK RNNKVDINPN HQTWKDHIKE VTDQMNRAQQ GNNNKPLKVQ IDGVSILTSE
     KYGTVGHWVD WVVDLIMLAQ VKMLIKEYKF KRLNSQNLMS GMNKLVGALR CYAYCLILAL
     YDYYGQDIEG FKKGSNSSAI LETVIQMFPN FKQEIQANFG INLNIKDKKT IAIRRATMHS
     DFSSNEEYGY KFVFGWAARG EEVLSNYGDV LSDEVEELFT KLRKKEHWDK VVEDPESYFI
     DELYQKNPAE VFYSAGYDTD QNVVIDGKMT EGVTYFSKRF VSYWYRVEKI TTKHLEFLTE
     ENRKVAQFDF EDYKPMAIGE MGIHASTYKY ESLLLGKNRG QKVNDSIALC NYDLALTNFG
     VSRRQDCCWI SSCSAIELSM RANIIIAIFR RIEDKRYENF AKILSGLTQQ QDLYFPTYKH
     YYLFVLQKVL RDERRIDLNR ICTELFDTQR RRGILLSFTA LRFWNDSEFL GDALMMNFLH
     RVVFEMENVD VDYGKKWHPL LVSSEKGLRV IAVDVFNSMM GVSTSGWLPY VERICSESDM
     RRRLNADELE LKRWFFDYYA TLPLERRGEP RLSFKYEGLT TWIGSNCGGV RDYVVQLLPM
     RKSKPGLLCI AYGDDVNVQW VEHELRDFLM HEGSLGLVVI SGKMLVNKSK LRVRNLKIYN
     RGTLDSLFLI SGGNYTFGNK FLLSKLMAKA E