ID   VP2_BTV10               Reviewed;         956 AA.
AC   P06945;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   23-FEB-2022, entry version 78.
DE   RecName: Full=Outer capsid protein VP2;
GN   Name=Segment-2;
OS   Bluetongue virus 10 (isolate USA) (BTV 10).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10900;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2991598; DOI=10.1128/jvi.55.3.826-830.1985;
RA   Purdy M.A., Ghiasi H., Rao C.D., Roy P.;
RT   "Complete sequence of bluetongue virus L2 RNA that codes for the antigen
RT   recognized by neutralizing antibodies.";
RL   J. Virol. 55:826-830(1985).
CC   -!- FUNCTION: The VP2 protein is one of the two proteins (with VP5) which
CC       constitute the virus particle outer capsid. It is the major target of
CC       the host immunogenic response. Responsible for viral attachment to
CC       target host cell, probably by binding to sialic acid. This attachment
CC       induces virion internalization predominantly through clathrin-dependent
CC       endocytosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP2 family. {ECO:0000305}.
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DR   EMBL; M11787; AAA42828.1; -; Genomic_RNA.
DR   PIR; A25484; P2XR10.
DR   RefSeq; YP_052958.1; NC_006013.1.
DR   SMR; P06945; -.
DR   GeneID; 2943152; -.
DR   KEGG; vg:2943152; -.
DR   Proteomes; UP000007662; Genome.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001742; Capsid_VP2_Orbivir.
DR   Pfam; PF00898; Orbi_VP2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Clathrin-mediated endocytosis of virus by host;
KW   Host-virus interaction; Inner capsid protein; Reference proteome;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..956
FT                   /note="Outer capsid protein VP2"
FT                   /id="PRO_0000222684"
SQ   SEQUENCE   956 AA;  111022 MW;  2BDA261973724810 CRC64;
     MEEFVIPVFS ERDIPYSLLN HYPLAIQIDV KVDDEGGKHN LIKIPESDMI DVPRLSIIEA
     LNYRPKRNDG VVVPRLLDIT LRAYDNRKSA KNAKGVEFMT DTKWMKWAID DKMDIQPLKV
     TLDNHCSVNH QLFNCIVKAR SANADTIYYD YYPLENGAKR CNHTNLDLLR SLTTTEMFHI
     LQGAAYALKT TYELVAHSER ENMSESYQVG TQRWIQLRKG TKIGYRGQPY ERFISSLVQV
     IIKGKIPDEI RTEIAELNRI KDEWKNAAYD RTEIRALELC KILSAIGRKM LDVQEEPKDE
     MALSTRFQFK LDEKFIRTDQ EHVNIFKVGG SATDDGRFYA LIAIAGTDTQ QGRVWRTNPY
     PCLRGALIAA ECELGDVYFT LRQTYKWSLR PEYGQRERPL EDNKYVFARL NLFDTNLAVG
     DEIIHWRYEV YQPKETTHDD GYICVSQKGD DELLCEVDED RYKEMFDRMI QGGWDQERFK
     LHNILTEPNL LTIDFEKDAY LGARSELVFP PYYDKWINSP MFNARLKIAR GEIATWKADD
     PWSNRAVHGY IKTSAESLEY ALGPYYDLRL QLFGDTLSLG QRQSAVFEHM AQQDDFSTLT
     DYTKGRTVCP HSGGTFYTFR KVALIILSNY ERLDPSLHEG REHETYMHPA VNDVFRRHVL
     EMKDFSQLIC FVFDYIFEKH VQLRNAKEAR RIIYLIQNTS GAYRLDVLRE AFPNFLKHVM
     NLRDVKRICD LNVINFFPLL FLVQDNISYW HRQWSIPMIL FDQVIRLIPV EVGAYANRFG
     LKSFFNFIRF HPGDSKKRQD ADDTHKEFGS ICFEYYTTTK ISQGEIDVPV VTSKLDTLKL
     HVASLCAGLA DSLVYTLPVA HPKKSIVLII VGDDKLEPQI RSEQIVNKYY YSRRHISGVV
     SICVNQGGQL KVHSMGITRH RICDKSILKY KCKVVLVRMP GHVFGNDELM TKLLNV