ID   VP2_BTV11               Reviewed;         956 AA.
AC   P05308;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   02-DEC-2020, entry version 68.
DE   RecName: Full=Outer capsid protein VP2;
GN   Name=Segment-2;
OS   Bluetongue virus 11 (isolate USA) (BTV 11).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=33716;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2820123; DOI=10.1016/0042-6822(87)90050-x;
RA   Ghiasi H., Fukusho A., Eshita Y., Roy P.;
RT   "Identification and characterization of conserved and variable regions in
RT   the neutralization VP2 gene of bluetongue virus.";
RL   Virology 160:100-109(1987).
CC   -!- FUNCTION: The VP2 protein is one of the two proteins (with VP5) which
CC       constitute the virus particle outer capsid. It is the major target of
CC       the host immunogenic response. Responsible for viral attachment to
CC       target host cell, probably by binding to sialic acid. This attachment
CC       induces virion internalization predominantly through clathrin-dependent
CC       endocytosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP2 family. {ECO:0000305}.
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DR   EMBL; M17437; AAA42829.1; -; Genomic_RNA.
DR   SMR; P05308; -.
DR   PRIDE; P05308; -.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001742; Capsid_VP2_Orbivir.
DR   Pfam; PF00898; Orbi_VP2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Clathrin-mediated endocytosis of virus by host;
KW   Host-virus interaction; Inner capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..956
FT                   /note="Outer capsid protein VP2"
FT                   /id="PRO_0000222685"
SQ   SEQUENCE   956 AA;  110050 MW;  366F8ADBCCDC382F CRC64;
     MEEFVIPVFS ETEIPYSLLS HYPLAVRTNV KIANVDEGHD VVKIPESDMI DVPRVSIVEA
     LAAKPTRNDG IVVPRLLDIT LRAYDDRKAM KSARGVEFMT NAKWMKWAID DRMDIQPLKV
     AIDDHNAVNH QLFNCIVKAR PANADTVYYS YFPLRDKVKK CNHTNLDLLR GLTTTEMFHM
     LQGAAYCLKS SYELITNSER NNTEETYAPG VHNRIRLVRG TRIGYKGEAY SRFVSSLVQV
     RIQGQTPPEI VDDIARLNEI RTEWINAQFD STKIRALELC KILSAIGRKM LNTHEEPKDE
     MDLSTRFQFK LDDKFKKTDS EHINIFNVGA PATHEGRFYA LIAIAATDTQ RGRVWRTNPY
     PCLRGALIAA ECQLGDVYHT LRQVYKWSLR QDYGRTEVPL ENNKYVFSRI NLFDSNLEVG
     DQVVHWKYEI DGPAETTYDN GYICKTERED GELVCKISEE KYKTMLDRMI QGGWDQERFK
     LYSVLTDPNL LTIDFEKDAY LNIRSEFVLP SYFDQWIYSP MFNARLRITH GEIGTRKSAD
     PWNKRVVFGY VKASTESPEY ALGQYFDTRI QLYGDALSLK QSQSAVFQHQ SQQEDFPVLT
     SYAKGDVVCP HSGGALYTFR KVALMLMANY ERLSPDLHEG MEDHTYTHPS IGGANQKRIL
     EMRDFSQLIC FIIDYIFERH DQLRDMREAR RILYLVQSLG EPQRLDVLSV ASPNFSRYFL
     KLKDVQRISD LNVINFLPLL FLIQDNISYW HRQWAVPMIL YDDTIKLIPV EVGAYANRFG
     IKSFFNFTRF HPGDAKKRQK ADDTHKEFGL ISFNYYANTK IAQGGVHTPV VTTKLDTLKI
     HLSSLCAGLA DSVVYTLPVA HPKKCIVLII VGDDKLEPHV RSEQVVSKYY FSRKHVSGVV
     SICIGQNDQL KVYSSGIVRH RICEKFILRY KCKVVLVKMP GYVFGNDELM TKLLNV