ID   VP2_BTV13               Reviewed;         959 AA.
AC   P12395;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   23-FEB-2022, entry version 71.
DE   RecName: Full=Outer capsid protein VP2;
GN   Name=Segment-2;
OS   Bluetongue virus 13 (isolate USA) (BTV 13).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=33717;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=2824673; DOI=10.1099/0022-1317-68-11-2967;
RA   Fukusho A., Ritter G.D., Roy P.;
RT   "Variation in the bluetongue virus neutralization protein VP2.";
RL   J. Gen. Virol. 68:2967-2973(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=7687805; DOI=10.1006/viro.1993.1445;
RA   Hwang G.-Y., Li J.K.-K.;
RT   "Identification and localization of a serotypic neutralization determinant
RT   on the VP2 protein of bluetongue virus 13.";
RL   Virology 195:859-862(1993).
CC   -!- FUNCTION: The VP2 protein is one of the two proteins (with VP5) which
CC       constitute the virus particle outer capsid. It is the major target of
CC       the host immunogenic response. Responsible for viral attachment to
CC       target host cell, probably by binding to sialic acid. This attachment
CC       induces virion internalization predominantly through clathrin-dependent
CC       endocytosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP2 family. {ECO:0000305}.
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DR   EMBL; D00153; BAA00108.1; -; Genomic_RNA.
DR   EMBL; L11874; AAA02767.1; -; Unassigned_DNA.
DR   EMBL; L11741; AAA42838.1; -; Genomic_RNA.
DR   PIR; A27495; P2XR13.
DR   SMR; P12395; -.
DR   PRIDE; P12395; -.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001742; Capsid_VP2_Orbivir.
DR   Pfam; PF00898; Orbi_VP2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Clathrin-mediated endocytosis of virus by host;
KW   Host-virus interaction; Inner capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..959
FT                   /note="Outer capsid protein VP2"
FT                   /id="PRO_0000222686"
FT   CONFLICT        326
FT                   /note="I -> V (in Ref. 2; AAA02767/AAA42838)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        349
FT                   /note="D -> G (in Ref. 2; AAA02767/AAA42838)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        466
FT                   /note="D -> N (in Ref. 2; AAA02767/AAA42838)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        910
FT                   /note="G -> D (in Ref. 2; AAA02767/AAA42838)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   959 AA;  112564 MW;  B64049F7EBD83562 CRC64;
     MEELVIPVIT ERFDKRLVGR YDYVIELARP EGDEWSGHDV THIPDRRMFD IKVQPIRDAI
     DYKPVENDGE VLPRILDMSI ACYDMRKRMM KRDGVDFVSD TKWLEWMIQD SMDVQPLKVD
     MKEDHSTVQY DMFSAKLHVD SRKADTTSYN ILALETKEGA QCHHVHTNIW NHMIRNHLFH
     AVQESCYIFK PTYKLTVNSE RRTPDEDFQI GNPQFLTLRR NQQIFLGDDA YKKTAKGLVQ
     VLVNGVVPDI IRNEIAALDA IRDKWIQGNY ERTHIKSLEL CNLLSAIGRK MVNLEEEPKD
     ERDLSLRFQH KLDDKFAKND QERNVIFAQK SQRNDQDRFY VLMVIAASDT NNSRVWWSNP
     YPCLRGALIA AECKLGDVYY KLRSWYEWSV REGYKPRDLD RQYEKYIVGR VNLFDLEAEP
     GTKVLHWEYE LISKLYTVSN HEGNQCDLHP DEGEIVTKFD DTRYSDMIQT IINEGWKQND
     FKMFKMLKDE GNPLLYDLEK DIKLDRVSRV VFPPYFDQWT YVPMFNARIK PCEVEVGERK
     NIDPYVKRTH RPLKADCIEL MRYHMSQYMD LRVSLQGTSL SIKQTPSSIH QSLARDASYA
     EILSRRRENL DYKSQCPIVT NLFLLEKFFL LIFTTMEKHY WEMDDDETEY EHPKIDPSKF
     EVEGTLHDVS QVMVHLFDRF FEKRRFLRTV DESRWILHLI RSASGARRLE VLSRFFPAFS
     DGLRIREFKK VRDIMLLNFL PFLFLTGDNI AYEHRQWAVP VIFYADKIMI IPAEVGAYYN
     RFGLTCILEL MMFFPSYDTR NENLSEDVRA CIGPIINYYL DTTISNGGIQ TSIVSTKALL
     YETYLSSICG GFSEAILWYL PITHPSKCLI ALEVSDALTS PELRIDKIKR RFPLSSNHLK
     GIVQISVRPG RTFSVVTQGI VKHRVCKKTL LRYRCDVILI QTPGYVFGND ELLTKLLNI