ID   VP2_BTV17               Reviewed;         955 AA.
AC   P05309;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   02-DEC-2020, entry version 70.
DE   RecName: Full=Outer capsid protein VP2;
GN   Name=Segment-2;
OS   Bluetongue virus 17 (isolate USA) (BTV 17).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=33718;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2820123; DOI=10.1016/0042-6822(87)90050-x;
RA   Ghiasi H., Fukusho A., Eshita Y., Roy P.;
RT   "Identification and characterization of conserved and variable regions in
RT   the neutralization VP2 gene of bluetongue virus.";
RL   Virology 160:100-109(1987).
CC   -!- FUNCTION: The VP2 protein is one of the two proteins (with VP5) which
CC       constitute the virus particle outer capsid. It is the major target of
CC       the host immunogenic response. Responsible for viral attachment to
CC       target host cell, probably by binding to sialic acid. This attachment
CC       induces virion internalization predominantly through clathrin-dependent
CC       endocytosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP2 family. {ECO:0000305}.
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DR   EMBL; M17438; AAA42830.1; -; Genomic_RNA.
DR   SMR; P05309; -.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001742; Capsid_VP2_Orbivir.
DR   Pfam; PF00898; Orbi_VP2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Clathrin-mediated endocytosis of virus by host;
KW   Host-virus interaction; Inner capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..955
FT                   /note="Outer capsid protein VP2"
FT                   /id="PRO_0000222687"
SQ   SEQUENCE   955 AA;  110573 MW;  E20CF75862FD6BAA CRC64;
     MEEFVIPVYS EDEIPYALLS RYPLAIQTNV KIEDVEGKHN VVKIPESDMI DIPKLTIVEA
     MNYKPARNDG IVVPRLLDIT LRAYDDRKST KSARGIEFMT NARWMKWAID DRMDIQPLKV
     TLDHYCSVNH QLFNCVVKAN AANADTIYYD YFPLEDYKKR CNHTNLDLLR SLTNMELFHA
     LQGAAYSIKS SYELVAYSER GSLEETYVVG QPKWIHLTRG TRIGNSGLSY ERFISSMVQV
     SVNGKIPDEI ANEIAQLNRI RAEWITATYD RGRIRALELC SILSTIGRKM LNTHEEPKDE
     MDLSTRFQFK LDEKFNRADS EHVNIFGVRG PATDEGRFYA LIAIAATDTQ KGRVWRTNPY
     PCLRGALVAA ECELGDVYST LRRVYTWSLR PEYGQHERQL ENNKYVFNRI NLFDSNLAVG
     DQIIHWRYEV KASAETTYDS GYMCRHEAEE DELLCKINED KYKEMLDRMI QGGWDQERFK
     LHNILTDPNL LTIDFEKDAY LNSRSELVLP DYFDKWISSP MFNARLRITK GEIGTSKKDD
     PWNNRAVRGY IKPLAESLDF VLGPYYDLRL LFFDETLSLK QEQSAVFQYL SQLDDFPALT
     QLRGDAVCPH SGGALYTFRK VALFLIGNYE KLSPDLHEGM EHQRYVHPST GGTYQKRVLE
     MKDSCQLTCF VIDYIFEKRE QLRDTKEARY IVYLIQSLTG TQRLSVLRST FPNFFQRLLM
     LKEIKFVRDL NVINFLPLMF LVHDNISYWH RQWSIPMVLF DDTIKLIPVE VGAYANRFGF
     KSFMNFTRFH PGELKKKQIA EDIHKEFGVV AFEYYTNTKI SQGNVHTPVM TTKMDVLRVH
     LSSLCAGLAD SVVYTLPVAH PKKCIVLIIV GDDKLEPHTR SEQIVSRYNY SRKHICGIVS
     VTIGQNSQLR VHTSGIVKHR VCDKFILKHK CKVILVRMPG YVFGNDELMT KLLNV