ID   VP2_BTV1A               Reviewed;         961 AA.
AC   P12434;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 2.
DT   23-FEB-2022, entry version 69.
DE   RecName: Full=Outer capsid protein VP2;
GN   Name=Segment-2;
OS   Bluetongue virus 1 (isolate Australia) (BTV 1).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10904;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2834696; DOI=10.1093/nar/16.6.2725;
RA   Yamaguchi S., Fukusho A., Roy P.;
RT   "Complete sequence of VP2 gene of the bluetongue virus serotype 1 (BTV-
RT   1).";
RL   Nucleic Acids Res. 16:2725-2725(1988).
RN   [2]
RP   SEQUENCE REVISION.
RA   Marshall J.;
RL   Submitted (FEB-1988) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2833046; DOI=10.1016/0168-1702(88)90029-9;
RA   Gould A.R.;
RT   "Conserved and non-conserved regions of the outer coat protein, VP2, of the
RT   Australian bluetongue serotype 1 virus, revealed by sequence comparison to
RT   the VP2 of North American BTV serotype 10.";
RL   Virus Res. 9:145-158(1988).
CC   -!- FUNCTION: The VP2 protein is one of the two proteins (with VP5) which
CC       constitute the virus particle outer capsid. It is the major target of
CC       the host immunogenic response. Responsible for viral attachment to
CC       target host cell, probably by binding to sialic acid. This attachment
CC       induces virion internalization predominantly through clathrin-dependent
CC       endocytosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X06464; CAA29772.1; -; Genomic_RNA.
DR   EMBL; M21844; AAA42844.1; -; Genomic_RNA.
DR   PIR; S03654; P2XRAU.
DR   SMR; P12434; -.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001742; Capsid_VP2_Orbivir.
DR   Pfam; PF00898; Orbi_VP2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Clathrin-mediated endocytosis of virus by host;
KW   Host-virus interaction; Inner capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..961
FT                   /note="Outer capsid protein VP2"
FT                   /id="PRO_0000222680"
FT   CONFLICT        13
FT                   /note="F -> V (in Ref. 3; AAA42844)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        72
FT                   /note="L -> V (in Ref. 3; AAA42844)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        186..188
FT                   /note="AYA -> LTL (in Ref. 3; AAA42844)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        200
FT                   /note="E -> D (in Ref. 3; AAA42844)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        557
FT                   /note="A -> D (in Ref. 3; AAA42844)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        750
FT                   /note="D -> N (in Ref. 3; AAA42844)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   961 AA;  112114 MW;  1D1408D3906ACD80 CRC64;
     MDELGIPIYK RGFPEHLLHG YEFTIDSSTK IQSVGGRHDV TKLPEMNAYD IKSEGMRTAL
     WYNPVRNDGF VLPRVLDITL RGYDGKRAVI DSSRHKSFHT DERWVQWMMK DSMDAQPLKV
     GLDDQTQKIA HSLHNCVVKI DSKKADTMSY HIEPIEDSLK GCLHTRTMLW NHLVRVEMSH
     AAQEIAYALK PTYDIVVHAE RRDRSQPFRP GDQTLINFSR GQKVQMNHNS YEKMVEGLAH
     LVIRGKTPEL IRDEITKLDE ICNRWIRSRY DPGEIKAYEL CKVLSTVGRK MLDQEKEPAD
     EANLSIRFQE AIDNKFRQHD SERLKIFEHR NQRRDEDRFY ILLMIAASDT FNTRVWWSNP
     YPCLRGTLIA SETKLGDVYS MMRLWYDWSV RPTYIPYEKS REQEKYIYGR VNLFDYVAEP
     GTKIIHWEYK LNQQIKDITY EQGNPCDLFP DDDEAIVTKF DDVAYGQMVN DLINGGWDQE
     RFKMHKILKS QGNVLTIDFE KDAKLTSNEG VAMPEYFDKW IIAPMFNAKL RIKHGEIAQR
     RNDDPMVKRT LSPIAFAPIV LQRLTLARFY DIRPAIMGQA LSRQQGQSTY DEEISKIEGY
     AEILQRRGIV QIPKKPCPTV TAQYTLERYA LFLINILEQH IIQSTDEDVM YSHPRVDYKL
     EVHGENIIDI SQIVIFVFDF LFERRRTVRG VYESRYMVTR IRDAQGQNRI NVITEFFPTF
     GYHLSRVKEA TIIQEIMYLN FLPLFFLVSD NIIYTHKQWS VPLFLYAHEL KVIPLEVGSY
     NDRCSLVSYI EYMVFFPSKA FRTSKLDEVQ PKIAREMLKY YINTKIFEGG INLNVVTTKQ
     LLYETYLASI CGGLSDGIVW YLPITHPNKC LVAIEVSDER VPASIRASHI KLRFPLSVKH
     LKGIVIIQVD EEGKFTVYSE GIVSHRVCKK NLLKYMCDIV LLKFSGHVFG NDEMLTKLLN
     V