ID   VP2_BTV1V               Reviewed;         961 AA.
AC   Q06997;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=Outer capsid protein VP2;
GN   Name=Segment-2;
OS   Bluetongue virus 1 (isolate South Africa vaccine) (BTV 1).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=36422;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2171239; DOI=10.1016/0168-1702(90)90078-p;
RA   Gould A.R., Pritchard L.I.;
RT   "Relationships amongst bluetongue viruses revealed by comparisons of capsid
RT   and outer coat protein nucleotide sequences.";
RL   Virus Res. 17:31-52(1990).
CC   -!- FUNCTION: The VP2 protein is one of the two proteins (with VP5) which
CC       constitute the virus particle outer capsid. It is the major target of
CC       the host immunogenic response. Responsible for viral attachment to
CC       target host cell, probably by binding to sialic acid. This attachment
CC       induces virion internalization predominantly through clathrin-dependent
CC       endocytosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP2 family. {ECO:0000305}.
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DR   EMBL; X55800; CAA39322.1; -; Genomic_RNA.
DR   PIR; A60017; A60017.
DR   SMR; Q06997; -.
DR   PRIDE; Q06997; -.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001742; Capsid_VP2_Orbivir.
DR   Pfam; PF00898; Orbi_VP2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Clathrin-mediated endocytosis of virus by host;
KW   Host-virus interaction; Inner capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..961
FT                   /note="Outer capsid protein VP2"
FT                   /id="PRO_0000222682"
SQ   SEQUENCE   961 AA;  111756 MW;  361405246E77E946 CRC64;
     MDELGIPVYK RGFPEHLLRG YEFTIDVGTK IESVGGRHDV TKIPEMNAYD IKQESIRTAL
     WYNPIRNDGI VLPRVLDITL RGYDERRAVV ESTRHKSFHT NDQWVQWMMK DSMDAQPLKV
     GLDDQSRNVA HSLHNCVVKI DSKKADTMSY HVEPIEDASK GCLHTRTMMW NHLVRIETFH
     TAQEVHILFK PTYDIVVHAE RRDRSQPFRP GDQTLINFGR GQKVHMNHNS YDKMVEGLTH
     LVMRGKMPEV IRDDIASLDE ICNRWIQSRH DPGEVKAYEL CKILSTIGRK VLDREKEPED
     EANLSIRFQE AIDNKFRQHD PERLKIFEHG NQRRDEDRFY ILLMIAASDT FNTRVWWSNP
     YPCLRGTLIA SETKLGDVYS MMRSWYDWSV RPTYTPYEKT REQEEYIYGR VNLFDFVAEP
     GIKIVHWEYR LNHSTREITY AQGNPCDLYP EDDDVIVTKF DDVAYGQMIN EMINGGWNQE
     QFKMHKILKT EGNVLTIDFE KDAKLTTNEG VTMPEYFNKW IIAPMFNANV RIKHEEIAQR
     QSDDPMVKRT LSPITADPIE LQRLTLARFY DIRPALRGQA LSRQQAQSTY DEEISKKAGY
     AEVLKRRGIV QIPKKPCPTV TAQYTLERYA LFIINYLQQH VARDCDEEAI YEHPKADHEL
     EIFGESIVDI SQVIVLVFDL IFERRRRVRD VYESRYIIAR IREMRGKEKL NVIAEFFPTY
     GSLLNGLSGA TVVQDIMYLN FLPLYFLVGD NMIYSHRQWS IPLLLYTHEV MVIPLEVGSY
     NDRCGLIAYL EYMVFFPSKA IRLSKLNEAH AKIAREMLKY YANTTVYDGG DNSNVVTTKQ
     LLYETYLASL CGGFLDGIVW YLPITHPNKC IVAIEVSDER VPASVRAGRI RLRFPLSARH
     LKGVVIIQVD LGGRFTVYSE GIVSHRVCKK NLLKYMCDII LLKFSGHVFG NDEMLTKLLN
     V