ID   VP2_BTV3V               Reviewed;         959 AA.
AC   Q06998;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=Outer capsid protein VP2;
GN   Name=Segment-2;
OS   Bluetongue virus 3 (isolate South Africa vaccine) (BTV 3).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=36424;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2171239; DOI=10.1016/0168-1702(90)90078-p;
RA   Gould A.R., Pritchard L.I.;
RT   "Relationships amongst bluetongue viruses revealed by comparisons of capsid
RT   and outer coat protein nucleotide sequences.";
RL   Virus Res. 17:31-52(1990).
CC   -!- FUNCTION: The VP2 protein is one of the two proteins (with VP5) which
CC       constitute the virus particle outer capsid. It is the major target of
CC       the host immunogenic response. Responsible for viral attachment to
CC       target host cell, probably by binding to sialic acid. This attachment
CC       induces virion internalization predominantly through clathrin-dependent
CC       endocytosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP2 family. {ECO:0000305}.
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DR   EMBL; X55801; CAA39323.1; -; Genomic_RNA.
DR   PIR; B60017; B60017.
DR   SMR; Q06998; -.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR001742; Capsid_VP2_Orbivir.
DR   Pfam; PF00898; Orbi_VP2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Clathrin-mediated endocytosis of virus by host;
KW   Host-virus interaction; Inner capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..959
FT                   /note="Outer capsid protein VP2"
FT                   /id="PRO_0000222683"
SQ   SEQUENCE   959 AA;  112164 MW;  41B230E31803588F CRC64;
     MEELVLPVIS RQFDKKLLGR YEYVIELAKP EQDEWTNHDV TQIPGRRMFD VAQQGIRDAM
     HLKPLENDGE VLPRILDMSI ACYDMRKTMM KKEGVDFVSN TRWLEWIIQD SMDVQPLRVH
     INEDHSTVQY DMFSAKVHID SRKADTTSYH AIAVETKAER KCCHVRTEVW NSVVRNHLFN
     TAQESCYTFK QTYELIVNSE RLSTEEEFRV GAPQFHTIQR NHRMQLGDNA YDKFLKGLVQ
     LRVSGTTPAK IRDEVAALDV IRDNWIRGSF DRSHIKSLEL CRLLSSIGRK MVNMEEEPKD
     EKDLSVKFQF RLDEKFSPND PERNVIFTSK THRTNEDRFY VLLVIAASDT NNGRVWWSNP
     YPCLRGALIA AECKLGDVYH TLRSKYAWGV RPTYKPKDLE REREKYVVGR VNLFDLEGEP
     ATKVIHWEYE LISPTYSVSN HKGNQCDLYP DDVEITTKFN EDRYREMIQS VIDDGWDQKN
     LKMYKILEEE GNPLLYDLEK DINLDSQSQV VFPSYYNKWT HAPMFNARVK PCDIELAERK
     NDDPFVKRTL KPIKADCVDL LRYHMSHYYD LRPCVKGVSL SIKQTPSGIH QALVQDDSYS
     RLLRRRDVDL DYSSPCPIIT NYFLLEKFHI LILTIMEKHY WELDDSDDVY EFPKIDASAF
     EVDGTLYDIS QTIVHMYDRF FEKRRVLRSI DESRWILHLI RISQGRERLE VIERFFPNYG
     KAMRQRDFKK VRDVMFLNFL PFFFLTGDNI SYEHRQWSIP IILYADKLRI LPIEVGAHYN
     RFGVTCILEL LNFFPSYEKR EEKLEEDIVL CADAIVNFYL QTTISNGGVQ TSIVSTKALL
     YEMYLSSICG GYSEGVLWYL PITHPVKCLV ALEVSDALVG ADVRIDKIKR RFPLSAKHLK
     GIVQISVHPN RTFSVTTCGI VKHKVCKKTL LKHRCDVILL QTPGYVFGND ELLTKLLNI