ID   VP2_CTFVL               Reviewed;        1209 AA.
AC   Q9ENL4;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Putative RNA methyltransferase VP2;
DE            EC=2.1.1.-;
OS   Colorado tick fever virus (strain USA/Florio N-7180) (CTFV).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Coltivirus;
OC   Colorado tick fever coltivirus.
OX   NCBI_TaxID=648168;
OH   NCBI_TaxID=76772; Callospermophilus lateralis (Golden-mantled ground squirrel) (Spermophilus lateralis).
OH   NCBI_TaxID=34620; Dermacentor andersoni (Rocky mountain wood tick).
OH   NCBI_TaxID=34844; Erethizon dorsatum (North American porcupine).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=105147; Neotoma cinerea (Bushy-tailed woodrat).
OH   NCBI_TaxID=10042; Peromyscus maniculatus (North American deer mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=10891382; DOI=10.1006/bbrc.2000.3057;
RA   Attoui H., Billoir F., Biagini P., Cantaloube J.F., de Chesse R.,
RA   de Micco P., de Lamballerie X.;
RT   "Sequence determination and analysis of the full-length genome of colorado
RT   tick fever virus, the type species of genus Coltivirus (Family
RT   Reoviridae).";
RL   Biochem. Biophys. Res. Commun. 273:1121-1125(2000).
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF139758; AAG00067.1; -; Genomic_RNA.
DR   RefSeq; NP_690892.1; NC_004182.1.
DR   PRIDE; Q9ENL4; -.
DR   GeneID; 993310; -.
DR   KEGG; vg:993310; -.
DR   Proteomes; UP000001675; Genome.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome; Transferase.
FT   CHAIN           1..1209
FT                   /note="Putative RNA methyltransferase VP2"
FT                   /id="PRO_0000403190"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          367..430
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1209 AA;  136981 MW;  DFDFD351FBB65EDC CRC64;
     MSARTKEKTK DKTKNDEQTV STEASAADRN DREKSSSSEP EDNAKETLTK KDSSSKKSVD
     VLAAMIEQKV QMSGSAGLGE FFGRMRPEIT DAFFAALERE ADVSKVVPSS LSKLDDGQVV
     DLLSVGEERT LSQSLFQLEV VTSIPHFYQL TAKQIGALGA QGGYLKAYHG EQVYPFIDPV
     ANQFGRGFDL AYVRINTSGQ GVELFIDPFD FDKVSCKVGG ESLTGIGLSN AVGVDEITYD
     DVKTPEQMME FVVLLIAGAA KMGRFCSSGV DARRRRKLFK TWVRRPVSDN FRHVQGWLLE
     DDYENYPHVP EALTVFSEYQ WFAREVADNM TDNGLGTSVQ MEDGPNIESF FNRKYREAAI
     CNLDFITAEA HANVMEELQN EKMNVSAYVD LLQSCQMGIF DIEGDTDTIK LKVYMREVED
     YEAELTRMML FPGDQLYVDC LRTAALVSPN IRQFILSVLI QQATSRVGLI ELLPVAEMTA
     SLTSRDNISV SHNMALTLAI GEWKELLRLT NPQQICQKIV CDIMAPFVDG LRMEDSLGVP
     TPSKLVFSLL GAKVALILTP NLYDYNLHLK AHLVTMILSC FFPDQYGALI ASRGYGHDVT
     GNRIDSIRDG ERTKKNCRFA TYTVLDPIPN GPPDRTRRKW LLMKRVQEWL LRNDLVRRRE
     IRDIIYRPYA NVLRLPGQTY LPRRQAAGAP LPCEVLLNDA IAILEEYRTV FHHPNDRNQG
     PQDRHALTTL SNLLRWYTRG FAEWFHWVYR PLYLQIALHP IIFWSHRLGQ GVWRQFPAVR
     EDRERRFDNH LEGVPFDSPV IAAFEPDVAL NPFTLRQGAD LLGRVHAQGS TFRGGAYDSA
     SVILLSEYEA LYRMTDSEGM VDEYIKTLMA SRQLLEGLRL VAELSTGELL RDTPILDYIR
     TAFCEGRFPS HIFFKILNLF GVKINHGVLA QVGERSIEHR LRGDYRVYYP RPGFLDPALE
     FIPDRIVVVD PVRPSVRRNV KLIMDAVFDP EFGMIKMRKG VTFSLRPTND LTFSSFHEIP
     PIQVEMTGNV NYVYDSETAR TRAEYDVQVR WEAPGRIITM NLLVTSSYEI LSSMEDILGR
     EVRAFSFVVQ DVSKFSGIYY DFMLSAVRKE HAIVWFPNLR GILHHHAISI EKVETCFKAA
     ELAQFSSFLS LRPTALIKLN VVQTTNIRGG ILPPSVSKPI LPCEGVHPSF IFALMSMWRR
     IGFAGLPSR