ID   VP2_EHDV1               Reviewed;         971 AA.
AC   Q00273;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Outer capsid protein VP2;
GN   Name=Segment-2; Synonyms=L2;
OS   Epizootic hemorrhagic disease virus 1 (EHDV-1).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=33720;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9872; Odocoileus hemionus (Mule deer) (Cervus hemionus).
OH   NCBI_TaxID=9874; Odocoileus virginianus (White-tailed deer).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1321879; DOI=10.1099/0022-1317-73-4-915;
RA   Iwata H., Chuma T., Roy P.;
RT   "Characterization of the genes encoding two of the major capsid proteins of
RT   epizootic haemorrhagic disease virus indicates a close genetic relationship
RT   to bluetongue virus.";
RL   J. Gen. Virol. 73:915-924(1992).
CC   -!- FUNCTION: The VP2 protein is one of the two proteins (with VP5) which
CC       constitute the virus particle outer capsid. It is the major target of
CC       the host immunogenic response.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP2 family. {ECO:0000305}.
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DR   EMBL; D10767; BAA01597.1; -; Genomic_RNA.
DR   PIR; JQ1634; JQ1634.
DR   PRIDE; Q00273; -.
DR   GO; GO:0039625; C:viral inner capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR001742; Capsid_VP2_Orbivir.
DR   Pfam; PF00898; Orbi_VP2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Inner capsid protein; Virion.
FT   CHAIN           1..971
FT                   /note="Outer capsid protein VP2"
FT                   /id="PRO_0000222691"
SQ   SEQUENCE   971 AA;  113249 MW;  61F26866A578447E CRC64;
     MEDINLTIFS DDALPHAVVV DDYVIAIKRN PNGTFLEPHQ MYDRYTQEFL QGKARDVLRQ
     NGRDGYKLII PEALSTGIIR YENKTKGAQS EVELENQLRS SIRHQRVKPR MDEAHRKLQI
     ELRGGQILLH PRIAESIEFS IISKENATCS HTPVNCAYEV LLSGGINVGT GTCYDLSSRL
     KLRVIGDVDR HRRSMQNVLG RVIHTGDPKI INRVNQIGSQ QFIDRAIGPD KFELKREIFD
     RLKALDVDVR KVIREEEASA ELDEMGRRWM RDQNVNIVND IIQSLVKKGS RSEKLAHRNE
     QGMQARFRRT IATNLRDQRQ GKEVLNIRGT RGQPEEKKFA AVLLMTGCDI VERAIWSNEE
     TAILRGLYAY AHDKLGCVYR AMKKDFVWSI RPTYTDRCAG VCDRKRTIMV REDYFDLQRE
     ENDSVYKWII TEWDKNDVII SAKNGYLYSK YSGEDEDDIL VHEIDDRLYT AMIDRILING
     WIEKEGLSQI IKEEVRLESF DFTKDAYVDE AGFLVLPEYY DRVIASNIYD CKFKISRVSI
     TSSSNDDPWD KKTADSIIDE QCLWKIPLPN IIDVRPCFRG DLLTSNSQEY SKRFSGIIDE
     LKKDKEIYDD FIPVQEGVRP CVQGHVCRYA FYRQKLTIFT ILKRYYPIER ILELTDEEDY
     EYNLYLDKEC YKKESLILNL RSIFSLICFL IDFGYEGREI TRGEDEYLKI FNEINYGGHA
     RKEAINKYFP QFYQRLMRVR TSENIEDLLP LAFYQALLLS DPCTDNSEKS SHPLILFCQD
     KVRVVPIRTA TQERGLPLLC CIHIFKFHPG LQMRKKELED DIKKTLPAIF DYWIELEMKR
     LDTGDRLRTR AQMVELYYST NCGGSYETLN FVFPIVHPNK GFIACVISSK GGMGALNEDD
     VRRRFRRIQS SIQGIFSISI DEEMEIQLHH SGNIQARILE KVFFEHKWHI VQVKLNGKIF
     ENHELITKLM N