ID   VP2_NVN68               Reviewed;         212 AA.
AC   Q83885;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 56.
DE   RecName: Full=Protein VP2;
DE   AltName: Full=Minor capsid protein;
GN   ORFNames=ORF3;
OS   Norwalk virus (strain GI/Human/United States/Norwalk/1968)
OS   (Hu/NV/NV/1968/US).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Picornavirales; Caliciviridae; Norovirus.
OX   NCBI_TaxID=524364;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8391187; DOI=10.1006/viro.1993.1345;
RA   Jiang X., Wang M., Wang K., Estes M.K.;
RT   "Sequence and genomic organization of Norwalk virus.";
RL   Virology 195:51-61(1993).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=10864672; DOI=10.1128/jvi.74.14.6581-6591.2000;
RA   Glass P.J., White L.J., Ball J.M., Leparc-Goffart I., Hardy M.E.,
RA   Estes M.K.;
RT   "Norwalk virus open reading frame 3 encodes a minor structural protein.";
RL   J. Virol. 74:6581-6591(2000).
RN   [3]
RP   FUNCTION.
RX   PubMed=14557646; DOI=10.1128/jvi.77.21.11603-11615.2003;
RA   Bertolotti-Ciarlet A., Crawford S.E., Hutson A.M., Estes M.K.;
RT   "The 3' end of Norwalk virus mRNA contains determinants that regulate the
RT   expression and stability of the viral capsid protein VP1: a novel function
RT   for the VP2 protein.";
RL   J. Virol. 77:11603-11615(2003).
RN   [4]
RP   REVIEW.
RX   PubMed=16168575; DOI=10.1016/j.femsle.2005.08.031;
RA   Hardy M.E.;
RT   "Norovirus protein structure and function.";
RL   FEMS Microbiol. Lett. 253:1-8(2005).
CC   -!- FUNCTION: Minor structural protein present in one or two copies per
CC       virion. Stabilizes capsid protein VP1 by protecting it from disassembly
CC       and degradation. May play a role in RNA genome packaging.
CC       {ECO:0000269|PubMed:14557646}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:10864672}. Host
CC       cytoplasm {ECO:0000269|PubMed:10864672}.
CC   -!- MISCELLANEOUS: Translated by a ribosomal termination-reinitiation
CC       process from the bicistronic mRNA coding for VP1 and VP2.
CC   -!- SIMILARITY: Belongs to the norovirus VP2 family. {ECO:0000305}.
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DR   EMBL; M87661; AAB50467.1; -; Genomic_RNA.
DR   PIR; A37471; A37471.
DR   RefSeq; NP_056822.1; NC_001959.2.
DR   PRIDE; Q83885; -.
DR   GeneID; 1491971; -.
DR   KEGG; vg:1491971; -.
DR   Proteomes; UP000000826; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004278; RNA_pol/capsid.
DR   Pfam; PF03035; RNA_capsid; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Reference proteome; Virion.
FT   CHAIN           1..212
FT                   /note="Protein VP2"
FT                   /id="PRO_0000341650"
SQ   SEQUENCE   212 AA;  22479 MW;  32DA45243148CA6D CRC64;
     MAQAIIGAIA ASTAGSALGA GIQVGGEAAL QSQRYQQNLQ LQENSFKHDR EMIGYQVEAS
     NQLLAKNLAT RYSLLRAGGL TSADAARSVA GAPVTRIVDW NGVRVSAPES SATTLRSGGF
     MSVPIPFASK QKQVQSSGIS NPNYSPSSIS RTTSWVESQN SSRFGNLSPY HAEALNTVWL
     TPPGSTASST LSSVPRGYFN TDRLPLFANN RR