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VP30_MABVA
ID   VP30_MABVA              Reviewed;         281 AA.
AC   Q1PD56;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Transcriptional activator VP30 {ECO:0000250|UniProtKB:Q05323};
DE   AltName: Full=Minor nucleoprotein VP30;
GN   Name=VP30;
OS   Lake Victoria marburgvirus (strain Angola/2005) (MARV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Filoviridae; Marburgvirus.
OX   NCBI_TaxID=378830;
OH   NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9407; Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate Ang0126, Isolate Ang0214, Isolate Ang0215, Isolate Ang0754,
RC   Isolate Ang1379c, Isolate Ang1381, and Isolate Ang1386;
RX   PubMed=16775337; DOI=10.1128/jvi.00069-06;
RA   Towner J.S., Khristova M.L., Sealy T.K., Vincent M.J., Erickson B.R.,
RA   Bawiec D.A., Hartman A.L., Comer J.A., Zaki S.R., Stroeher U.,
RA   Gomes da Silva F., del Castillo F., Rollin P.E., Ksiazek T.G., Nichol S.T.;
RT   "Marburgvirus genomics and association with a large hemorrhagic fever
RT   outbreak in Angola.";
RL   J. Virol. 80:6497-6516(2006).
CC   -!- FUNCTION: Acts as a transcription anti-termination factor immediately
CC       after transcription initiation, but does not affect transcription
CC       elongation. This function has been found to be dependent on the
CC       formation of an RNA secondary structure at the transcription start site
CC       of the first gene (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}.
CC       Note=Tightly bound in the nucleocapsid.
CC   -!- PTM: Phosphorylated by host. Phosphorylation negatively regulates the
CC       transcription activation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the filoviridae transcriptional activator VP30
CC       family. {ECO:0000305}.
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DR   EMBL; DQ447653; ABE27016.1; -; Genomic_RNA.
DR   EMBL; DQ447654; ABE27023.1; -; Genomic_RNA.
DR   EMBL; DQ447655; ABE27030.1; -; Genomic_RNA.
DR   EMBL; DQ447656; ABE27037.1; -; Genomic_RNA.
DR   EMBL; DQ447657; ABE27044.1; -; Genomic_RNA.
DR   EMBL; DQ447658; ABE27051.1; -; Genomic_RNA.
DR   EMBL; DQ447659; ABE27058.1; -; Genomic_RNA.
DR   SMR; Q1PD56; -.
DR   Proteomes; UP000008242; Genome.
DR   Proteomes; UP000097432; Genome.
DR   Proteomes; UP000102513; Genome.
DR   Proteomes; UP000115353; Genome.
DR   Proteomes; UP000130744; Genome.
DR   Proteomes; UP000168007; Genome.
DR   Proteomes; UP000171838; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR014459; VP30_FiloV.
DR   Pfam; PF11507; Transcript_VP30; 1.
DR   PIRSF; PIRSF011356; VP30_FiloV; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Metal-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Viral nucleoprotein; Virion; Zinc; Zinc-finger.
FT   CHAIN           1..281
FT                   /note="Transcriptional activator VP30"
FT                   /id="PRO_0000314992"
FT   ZN_FING         78..96
FT                   /note="C3H1-type; atypical"
FT                   /evidence="ECO:0000250"
FT   REGION          1..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  31594 MW;  3851A3596877760F CRC64;
     MQQPRGRSRT RNHQATPSIY HETQLPSKPH YTNHHPRARS MSSTRSSAES SPTNHIPRAR
     PPSTFNLSKP PPPPKDMCRN MKIGLPCTDP TCNRDHDLDN LTNRELLLLM ARKMLPNTDK
     TFRSPQDCGS PSLSKGLSKD KQEQTKDVLT LENLGHILSY LHRSEIGKLD ETSLRAALSL
     TCAGIRKTNR SLINTMTELH INHENLPQDQ NGVIKQTYTG IHLDKGGQFE AALWQGWDKR
     SISLFVQAAL YVMNNIPCES SISVQASYDH FILPQSQGKG Q
 
 
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