ID   VP30_MABVP              Reviewed;         281 AA.
AC   P41326;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Transcriptional activator VP30 {ECO:0000250|UniProtKB:Q05323};
DE   AltName: Full=Minor nucleoprotein VP30;
GN   Name=VP30;
OS   Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain
OS   West Germany/Popp/1967)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Filoviridae; Marburgvirus.
OX   NCBI_TaxID=33728;
OH   NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9407; Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7773195;
RA   Bukreyev A.A., Belanov E.F., Blinov V.M., Netesov S.V.;
RT   "Complete nucleotide sequences of Marburg virus genes 5 and 6 encoding VP30
RT   and VP24 proteins.";
RL   Biochem. Mol. Biol. Int. 35:605-613(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7487490; DOI=10.1007/bf01322532;
RA   Bukreyev A.A., Volchkov V.E., Blinov V.M., Dryga S.A., Netesov S.V.;
RT   "The complete nucleotide sequence of the Popp (1967) strain of Marburg
RT   virus: a comparison with the Musoke (1980) strain.";
RL   Arch. Virol. 140:1589-1600(1995).
CC   -!- FUNCTION: Acts as a transcription anti-termination factor immediately
CC       after transcription initiation, but does not affect transcription
CC       elongation. This function has been found to be dependent on the
CC       formation of an RNA secondary structure at the transcription start site
CC       of the first gene (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}.
CC       Note=Tightly bound in the nucleocapsid.
CC   -!- PTM: Phosphorylated by host. Phosphorylation negatively regulates the
CC       transcription activation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the filoviridae transcriptional activator VP30
CC       family. {ECO:0000305}.
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DR   EMBL; X64405; CAA45746.1; -; Genomic_RNA.
DR   EMBL; Z29337; CAA82540.1; -; Genomic_RNA.
DR   PIR; S44052; S44052.
DR   SMR; P41326; -.
DR   Proteomes; UP000007772; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR014459; VP30_FiloV.
DR   Pfam; PF11507; Transcript_VP30; 1.
DR   PIRSF; PIRSF011356; VP30_FiloV; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Metal-binding; Phosphoprotein; Transcription;
KW   Viral nucleoprotein; Virion; Zinc; Zinc-finger.
FT   CHAIN           1..281
FT                   /note="Transcriptional activator VP30"
FT                   /id="PRO_0000222160"
FT   ZN_FING         78..96
FT                   /note="C3H1-type; atypical"
FT                   /evidence="ECO:0000250"
FT   REGION          1..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          122..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..77
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  31641 MW;  4AD8F410CEC1C5B9 CRC64;
     MQQPRGRSRT RNHQTASSIY HETQLPSKPH YTNHHPRARS MSSTRSSAES SPTNHIPRAR
     PPPTFNLSKP PPPPKDMCRN MKIGLPCTDP TCNRDHDLDN LTNRELLLLM ARKMLPNTDK
     TFRSLQDCGS PSLSKGLSKD KQEQTKDVLT LENLGHILNY LHRSDIGKLD ETSLRAALSL
     TCAGIRKTNR SLINTMTELH INHENLPQDQ NGVIKQTYTG IHLDKGGQFE AALWQGWDKR
     SISLFVQAAL YVMNNIPCES STSVQASYDH FILPQSQSKG Q