ID   VP33B_DANRE             Reviewed;         617 AA.
AC   Q58EN8;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Vacuolar protein sorting-associated protein 33B {ECO:0000250|UniProtKB:Q9H267};
GN   Name=vps33b {ECO:0000312|ZFIN:ZDB-GENE-050327-73};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABB59728.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=16284120; DOI=10.1242/dev.02140;
RA   Matthews R.P., Plumb-Rudewiez N., Lorent K., Gissen P., Johnson C.A.,
RA   Lemaigre F., Pack M.;
RT   "Zebrafish vps33b, an ortholog of the gene responsible for human
RT   arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary
RT   development downstream of the onecut transcription factor hnf6.";
RL   Development 132:5295-5306(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:AAH91824.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH91824.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=20190753; DOI=10.1038/ng.538;
RA   Cullinane A.R., Straatman-Iwanowska A., Zaucker A., Wakabayashi Y.,
RA   Bruce C.K., Luo G., Rahman F., Gurakan F., Utine E., Ozkan T.B.,
RA   Denecke J., Vukovic J., Di Rocco M., Mandel H., Cangul H., Matthews R.P.,
RA   Thomas S.G., Rappoport J.Z., Arias I.M., Wolburg H., Knisely A.S.,
RA   Kelly D.A., Muller F., Maher E.R., Gissen P.;
RT   "Mutations in VIPAR cause an arthrogryposis, renal dysfunction and
RT   cholestasis syndrome phenotype with defects in epithelial polarization.";
RL   Nat. Genet. 42:303-312(2010).
CC   -!- FUNCTION: May play a role in vesicle-mediated protein trafficking to
CC       lysosomal compartments and in membrane docking/fusion reactions of late
CC       endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages.
CC       Proposed to be involved in endosomal maturation implicating vipas39. In
CC       epithelial cells, the vps33b:vipas39 complex may play a role in the
CC       apical recycling pathway and in the maintenance of the apical-
CC       basolateral polarity (By similarity). Plays a role in bile duct
CC       development. {ECO:0000250|UniProtKB:P59016,
CC       ECO:0000250|UniProtKB:Q9H267, ECO:0000269|PubMed:16284120,
CC       ECO:0000269|PubMed:20190753}.
CC   -!- SUBUNIT: Interacts with vipas39. {ECO:0000250|UniProtKB:P59016,
CC       ECO:0000250|UniProtKB:Q9H267}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane
CC       {ECO:0000250|UniProtKB:Q9H267}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9H267}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q9H267}. Lysosome membrane
CC       {ECO:0000250|UniProtKB:Q9H267}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9H267}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q9H267}. Note=Cytoplasmic, peripheral membrane
CC       protein associated with late endosomes/lysosomes.
CC       {ECO:0000250|UniProtKB:Q9H267}.
CC   -!- TISSUE SPECIFICITY: Widely expressed from 4 hours post-fertilization
CC       (hpf) to 24 hpf. At 48 hpf, localized to brain, retina, ear, liver and
CC       proximal intestine. This expression pattern is more pronounced at 72
CC       hpf and persists through 5 days post-fertilization (dpf). At 3 dpf and
CC       4 dpf, expression in the liver is predominantly in developing biliary
CC       epithelial cells. No expression detected in kidney or spinal cord.
CC       {ECO:0000269|PubMed:16284120, ECO:0000269|PubMed:20190753}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000255}.
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DR   EMBL; DQ230986; ABB59728.1; -; mRNA.
DR   EMBL; CR382298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC091824; AAH91824.1; -; mRNA.
DR   RefSeq; NP_001014370.1; NM_001014348.1.
DR   AlphaFoldDB; Q58EN8; -.
DR   SMR; Q58EN8; -.
DR   STRING; 7955.ENSDARP00000065867; -.
DR   PaxDb; Q58EN8; -.
DR   PRIDE; Q58EN8; -.
DR   GeneID; 541534; -.
DR   KEGG; dre:541534; -.
DR   CTD; 26276; -.
DR   ZFIN; ZDB-GENE-050327-73; vps33b.
DR   eggNOG; KOG1302; Eukaryota.
DR   InParanoid; Q58EN8; -.
DR   OrthoDB; 406738at2759; -.
DR   PhylomeDB; Q58EN8; -.
DR   PRO; PR:Q58EN8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0033263; C:CORVET complex; IBA:GO_Central.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR   GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0035622; P:intrahepatic bile duct development; IMP:ZFIN.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 1.25.40.850; -; 1.
DR   Gene3D; 3.40.50.1910; -; 2.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   Gene3D; 3.90.830.10; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   InterPro; IPR027121; VPS33.
DR   InterPro; IPR043155; VPS33_dom3b.
DR   PANTHER; PTHR11679; PTHR11679; 1.
DR   PANTHER; PTHR11679:SF77; PTHR11679:SF77; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   SUPFAM; SSF56815; SSF56815; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Endosome; Lysosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..617
FT                   /note="Vacuolar protein sorting-associated protein 33B"
FT                   /id="PRO_0000395315"
SQ   SEQUENCE   617 AA;  70429 MW;  BA3B205E413A5940 CRC64;
     MAQTERRDAP ELPDFSLLKR LARDQLIFLL EQLPGKKDLF IDADLMSPLD RIANVTILKQ
     HEVDKLYKVE LKPIVSSSDQ LCFLIRPRIQ TVKWISDLVN SDKVAGRFRR YKIIFTPQKF
     YACETVLEEQ GVYGDVTTDE WNFYILPLDD DILSLELPEF FRDNFLEGDQ RWVTTGGGAL
     HLLQSVYGSF SKVYGIGRCA KMVYESWREL MEEGEQRTRQ PEFAKVFLID RDVDFVTPLC
     SQVVYEGLVD DIFRIKCSSV EFGPDVTSSD KSIKVMLNSQ DKVFNEIRNE HFSNVFGFLS
     QKAKNLQTAY DKRRGMDIQQ MKAFVADELK GLKQEHRLLS LHIGASESIM KKKTKQDFQE
     LLKTEHSLLE GFEIRECIAY IEEHINRQVS MIDSLRLLCL LSITENGLLS KDYRSLKAQY
     LQSYGIEHLL TFANLRQLGL LEEQQTGETL TVMESKVGKL VNDKTAGKLT DAFSSLAKKS
     NFRALSKRLA LVPKSGEEYD LRVPRDMAYI FSGAYIPLSC KLIEQVLERD GWTGLEEVTR
     MLNGQDFAVT GGSSSSEARN KSNGQRIILV MFLGGCTYSE ISALRFLGKE RGCRFIVLTT
     AITNSGRLLE ALLDKHV