ID   VP33_APLCA              Reviewed;         260 AA.
AC   Q16943;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Vesicle-associated membrane protein/synaptobrevin-binding protein;
DE   AltName: Full=VAP-33;
OS   Aplysia californica (California sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=6500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7667638; DOI=10.1126/science.7667638;
RA   Skehel P.A., Martin K.C., Kandel E.R., Bartsch D.;
RT   "A VAMP-binding protein from Aplysia required for neurotransmitter
RT   release.";
RL   Science 269:1580-1583(1995).
CC   -!- FUNCTION: Required for neurotransmitter release. Interacts with VAMP.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}. Synapse, synaptosome.
CC   -!- TISSUE SPECIFICITY: Detected only in the central nervous system and the
CC       gill of aplysia.
CC   -!- SIMILARITY: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17)
CC       family. {ECO:0000305}.
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DR   EMBL; U36779; AAC46883.1; -; mRNA.
DR   PIR; A57245; A57245.
DR   RefSeq; NP_001191451.1; NM_001204522.1.
DR   AlphaFoldDB; Q16943; -.
DR   SMR; Q16943; -.
DR   GeneID; 100533208; -.
DR   OrthoDB; 1332028at2759; -.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000535; MSP_dom.
DR   InterPro; IPR008962; PapD-like_sf.
DR   InterPro; IPR016763; VAP.
DR   PANTHER; PTHR10809; PTHR10809; 2.
DR   Pfam; PF00635; Motile_Sperm; 1.
DR   PIRSF; PIRSF019693; VAMP-associated; 1.
DR   SUPFAM; SSF49354; SSF49354; 1.
DR   PROSITE; PS50202; MSP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Synapse; Synaptosome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..260
FT                   /note="Vesicle-associated membrane protein/synaptobrevin-
FT                   binding protein"
FT                   /id="PRO_0000213469"
FT   TOPO_DOM        1..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          7..125
FT                   /note="MSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00132"
FT   REGION          127..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          172..216
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        156..170
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  28329 MW;  0F01CABE63C732FE CRC64;
     MASHEQALIL EPAGELRFKG PFTDVVTADL KLSNPTDRRI CFKVKTTAPK RYCVRPNSGI
     LEPKTSIAVA VMLQPFNYDP NEKNKHKFMV QSMYAPDHVV ESQELLWKDA PPESLMDTKL
     RCVFEMPDGS HQAPASDASR ATDAGAHFSE SALEDPTVAS RKTETQSPKR VGAVGSAGED
     VKKLQHELKK AQSEITSLKG ENSQLKDEGI RLRKVAMTDT VSPTPLNPSP APAAAVRAFP
     PVVYVVAAII LGLIIGKFLL