ID   VP35C_ARATH             Reviewed;         790 AA.
AC   A8R7K9; Q9SD18;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Vacuolar protein sorting-associated protein 35C;
DE   AltName: Full=Vesicle protein sorting 35C;
GN   Name=VPS35C; OrderedLocusNames=At3g51310; ORFNames=F24M12.350;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX   PubMed=18222962; DOI=10.1093/pcp/pcn006;
RA   Yamazaki M., Shimada T., Takahashi H., Tamura K., Kondo M., Nishimura M.,
RA   Hara-Nishimura I.;
RT   "Arabidopsis VPS35, a retromer component, is required for vacuolar protein
RT   sorting and involved in plant growth and leaf senescence.";
RL   Plant Cell Physiol. 49:142-156(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   COMPONENT OF THE RETROMER COMPLEX, AND SUBCELLULAR LOCATION.
RX   PubMed=16582012; DOI=10.1105/tpc.105.035907;
RA   Oliviusson P., Heinzerling O., Hillmer S., Hinz G., Tse Y.C., Jiang L.,
RA   Robinson D.G.;
RT   "Plant retromer, localized to the prevacuolar compartment and microvesicles
RT   in Arabidopsis, may interact with vacuolar sorting receptors.";
RL   Plant Cell 18:1239-1252(2006).
CC   -!- FUNCTION: Plays a role in vesicular protein sorting. Component of the
CC       membrane-associated retromer complex which is essential in endosome-to-
CC       Golgi retrograde transport. Also involved in the efficient sorting of
CC       seed storage proteins (By similarity). The VPS29-VPS26-VPS35 subcomplex
CC       may be involved in recycling of specific cargos from endosome to the
CC       plasma membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the retromer complex which consists of VPS29
CC       (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or VPS35B or VPS35C),
CC       VPS5/17 (SNX1 or SNX2A or SNX2B). Component of a retromer subcomplex
CC       consisting of VPS29 (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or
CC       VPS35B or VPS35C).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane; Peripheral membrane
CC       protein; Cytoplasmic side. Prevacuolar compartment membrane; Peripheral
CC       membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi
CC       network membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS35 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB62653.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB368490; BAF93445.1; -; mRNA.
DR   EMBL; AL132980; CAB62653.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE78777.1; -; Genomic_DNA.
DR   PIR; T45762; T45762.
DR   RefSeq; NP_190699.3; NM_114990.5.
DR   AlphaFoldDB; A8R7K9; -.
DR   SMR; A8R7K9; -.
DR   STRING; 3702.AT3G51310.1; -.
DR   PaxDb; A8R7K9; -.
DR   PRIDE; A8R7K9; -.
DR   ProteomicsDB; 242564; -.
DR   EnsemblPlants; AT3G51310.1; AT3G51310.1; AT3G51310.
DR   GeneID; 824294; -.
DR   Gramene; AT3G51310.1; AT3G51310.1; AT3G51310.
DR   KEGG; ath:AT3G51310; -.
DR   Araport; AT3G51310; -.
DR   TAIR; locus:2080888; AT3G51310.
DR   eggNOG; KOG1107; Eukaryota.
DR   HOGENOM; CLU_005836_1_0_1; -.
DR   InParanoid; A8R7K9; -.
DR   OMA; WADECEN; -.
DR   OrthoDB; 316875at2759; -.
DR   PhylomeDB; A8R7K9; -.
DR   PRO; PR:A8R7K9; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; A8R7K9; baseline and differential.
DR   Genevisible; A8R7K9; AT.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:TAIR.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IDA:TAIR.
DR   GO; GO:0005771; C:multivesicular body; IDA:TAIR.
DR   GO; GO:0030904; C:retromer complex; IDA:TAIR.
DR   GO; GO:0030906; C:retromer, cargo-selective complex; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   Gene3D; 1.25.40.660; -; 1.
DR   InterPro; IPR005378; Vps35.
DR   InterPro; IPR042491; Vps35_C.
DR   PANTHER; PTHR11099; PTHR11099; 1.
DR   Pfam; PF03635; Vps35; 1.
DR   PIRSF; PIRSF009375; Retromer_Vps35; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Endosome; Golgi apparatus; Membrane;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..790
FT                   /note="Vacuolar protein sorting-associated protein 35C"
FT                   /id="PRO_0000414726"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7X659"
SQ   SEQUENCE   790 AA;  89405 MW;  B1F8D87B163BFE8A CRC64;
     MIADDDEKWL AAAIAAVKQN AFYMQRAIDS NNLKDALKFS AQMLSELRTS KLSPHKYYEL
     YMRVFNELGT LEIFFKEETG RGCSIAELYE LVQHAGNILP RLYLLCTIGS VYIKSKDVTA
     TDILKDLVEM CRAVQHPLRG LFLRSYLAQV TRDKLPSIGS DLEGDGDAHM NALEFVLQNF
     TEMNKLWVRM QHQGPSREKE KREKERNELR DLVGKNLHVL SQLEGVDLGI YRDTVLPRIL
     EQVVNCKDEL AQCYLMDCII QVFPDDFHLQ TLDVLLGACP QLQPSVDIKT VLSGLMERLS
     NYAASSVEAL PNFLQVEAFS KLNYAIGKVV EAQADLPAAA SVTLYLFLLK FTLHVYSDRL
     DYVDQVLGSC VTQLSATGKL CDDKAAKQIV AFLSAPLEKY NNVVTILKLT NYPLVMEYLD
     RETNKAMAII LVQSVFKNNT HIATADEVDA LFELAKGLMK DFDGTIDDEI DEEDFQEEQN
     LVARLVNKLY IDDPEEMSKI IFTVRKHIVA GGPKRLPLTI PPLVFSALKL IRRLRGGDEN
     PFGDDASATP KRILQLLSET VEVLSDVSAP DLALRLYLQC AQAANNCELE TVAYEFFTKA
     YLLYEEEISD SKAQVTALRL IIGTLQRMRV FNVENRDTLT HKATGYSARL LRKPDQCRAV
     YECAHLFWAD ECENLKDGER VVLCLKRAQR IADAVQQMAN ASRGTSSTGS VSLYVELLNK
     YLYFLEKGNQ QVTGDTIKSL AELIKSETKK VESGAEPFIN STLRYIEFQR QQEDGGMNEK
     YEKIKMEWFE