VP35L_DICDI
ID VP35L_DICDI Reviewed; 987 AA.
AC Q557H3; Q86AU0;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=VPS35 endosomal protein sorting factor-like {ECO:0000305};
GN ORFNames=DDB_G0273473;
GN and
GN ORFNames=DDB_G0273559;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Acts as component of the retriever complex. The retriever
CC complex is a heterotrimeric complex related to retromer cargo-selective
CC complex (CSC) and essential for retromer-independent retrieval and
CC recycling of numerous cargos. {ECO:0000250|UniProtKB:Q7Z3J2}.
CC -!- SUBUNIT: Component of the heterotrimeric retriever complex.
CC {ECO:0000250|UniProtKB:Q7Z3J2}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q7Z3J2}.
CC -!- SIMILARITY: Belongs to the VPS35L family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000010; EAL70691.1; -; Genomic_DNA.
DR EMBL; AAFI02000010; EAL70734.1; -; Genomic_DNA.
DR RefSeq; XP_644589.1; XM_639497.1.
DR RefSeq; XP_644662.1; XM_639570.1.
DR AlphaFoldDB; Q557H3; -.
DR STRING; 44689.DDB0237526; -.
DR PaxDb; Q557H3; -.
DR EnsemblProtists; EAL70691; EAL70691; DDB_G0273473.
DR EnsemblProtists; EAL70734; EAL70734; DDB_G0273559.
DR GeneID; 8618953; -.
DR GeneID; 8619024; -.
DR KEGG; ddi:DDB_G0273473; -.
DR KEGG; ddi:DDB_G0273559; -.
DR dictyBase; DDB_G0273473; -.
DR dictyBase; DDB_G0273559; -.
DR eggNOG; KOG3682; Eukaryota.
DR HOGENOM; CLU_012270_0_0_1; -.
DR InParanoid; Q557H3; -.
DR OMA; MANLEWV; -.
DR PhylomeDB; Q557H3; -.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR PRO; PR:Q557H3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR029705; VPS35L.
DR PANTHER; PTHR13673; PTHR13673; 1.
PE 3: Inferred from homology;
KW Endosome; Protein transport; Reference proteome; Transport.
FT CHAIN 1..987
FT /note="VPS35 endosomal protein sorting factor-like"
FT /id="PRO_0000356853"
FT REGION 1..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 112505 MW; C9218F24E046663C CRC64;
MAERQSASSP TPSSPPQQQQ QTPQQPPQYL LNSKKNFKVK VLNGREVERH PLNSITKTED
TGKPKQSSLS SNASSLQSAA AAASSSTATT DIDPLNNNNN NNTDIDPLNN PLEKKHDPLS
ETIATMGGLK LIKENHLTNY VDENFMPWDT LKPSILQQYT SDDSNPIQVS FMSTGTSGKI
KIPINRLNKI LEELEQDKED SKSTQFSQPD IIMDLETLHS ELLKAWAAEE RVRSLKIAIQ
TAKLLSDTSL IKFYPSKFVI ATEILDTFGN LVYDRIKKRL QSSKESKNHE ILLKEQAKET
CRNWFYKIAS IRELLPRLFV EISILKCYEF IQGDVNTEPK QVINRISEMI RGIGNPLVAN
YIRAYLTRRS FDLCPEYKKF VIQLLKDFVF TQKSYEKSKY LENTLSMYRI TLTDYMGLYS
PSLEWLLQCL AHKATPETLE EVLELFRESK NSLLLNHIIS SFPPEYICSN STMFSNFIKD
ADTLSYPKYQ LYSTFGVNLV LGQPPKNQIL SILNDVWKVV TNFENIKDYI SVAEVFIEYV
LTHCSEKETD VFLKDILRHI IPDKGYETIQ SHLQSIVLKI FTHISDFGKL VSFTNFLPLL
DLFNGESQKQ ISRSTLEALS TSKVMTSDPI LINTFLTYGK ALHDSLNSLS FQDEVRQVTQ
LVVNCINKID FGRDVEKQLN FYVECRQTFI NFDGVKNRLV YGVCEICEKT LNLVKGKHTP
KTTSFIRACV AYCFITIPSI DDIFLKMNLY LVSSSVALQN QALSQADALL KAAITFIQEI
PPILEFKQVK STEDWTISYV SDFISLLVVT PGHPESGPFY LVKALYKVIK EYQWESSSTA
KSKLFIQLLL LCSSWAQTSL PYHIEKVESN DQLFTEDPEF NTELTEFYNS LIKEILYDLN
LLKDEPDNLT QKKVGIICID LINALLNVGE LNSKTASLIF NLYNMAKKII PSTCFNEITY
LKNTLAFIGT LESKMGQDIF NKLSQQQ
