VP35L_DROME
ID VP35L_DROME Reviewed; 942 AA.
AC Q9VHM2; Q960B2;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 3.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=VPS35 endosomal protein sorting factor-like {ECO:0000305};
GN ORFNames=CG8202;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP SEQUENCE REVISION.
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as component of the retriever complex. The retriever
CC complex is a heterotrimeric complex related to retromer cargo-selective
CC complex (CSC) and essential for retromer-independent retrieval and
CC recycling of numerous cargos. {ECO:0000250|UniProtKB:Q7Z3J2}.
CC -!- SUBUNIT: Component of the heterotrimeric retriever complex.
CC {ECO:0000250|UniProtKB:Q7Z3J2}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q7Z3J2}.
CC -!- SIMILARITY: Belongs to the VPS35L family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK93567.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014297; AAF54281.3; -; Genomic_DNA.
DR EMBL; AY052143; AAK93567.2; ALT_INIT; mRNA.
DR RefSeq; NP_649826.3; NM_141569.4.
DR AlphaFoldDB; Q9VHM2; -.
DR STRING; 7227.FBpp0081397; -.
DR PaxDb; Q9VHM2; -.
DR PRIDE; Q9VHM2; -.
DR DNASU; 41043; -.
DR EnsemblMetazoa; FBtr0081914; FBpp0081397; FBgn0037622.
DR GeneID; 41043; -.
DR KEGG; dme:Dmel_CG8202; -.
DR UCSC; CG8202-RA; d. melanogaster.
DR FlyBase; FBgn0037622; CG8202.
DR VEuPathDB; VectorBase:FBgn0037622; -.
DR eggNOG; KOG3682; Eukaryota.
DR GeneTree; ENSGT00390000011343; -.
DR HOGENOM; CLU_012270_0_0_1; -.
DR InParanoid; Q9VHM2; -.
DR OMA; MANLEWV; -.
DR OrthoDB; 247677at2759; -.
DR PhylomeDB; Q9VHM2; -.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 41043; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41043; -.
DR PRO; PR:Q9VHM2; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037622; Expressed in embryonic/larval hemocyte (Drosophila) and 27 other tissues.
DR ExpressionAtlas; Q9VHM2; baseline and differential.
DR Genevisible; Q9VHM2; DM.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR029705; VPS35L.
DR PANTHER; PTHR13673; PTHR13673; 1.
PE 2: Evidence at transcript level;
KW Endosome; Protein transport; Reference proteome; Transport.
FT CHAIN 1..942
FT /note="VPS35 endosomal protein sorting factor-like"
FT /id="PRO_0000311357"
SQ SEQUENCE 942 AA; 107596 MW; E7DC1B5B8650CF69 CRC64;
MANLEWVCVP RCYEVRKNCL TGQATLEHPL KQRTVTVVDS NPLSRALEGT DPLSQFARQD
DELNDPLSQM VSEFDLKSKR RERDRTEPED NTLQWSSRRL GILNRFTTNE KLSLSTSFLV
SSGSLDGGNE SIKAQTVVAD KTKFRLEQLD HFDDGSMRHM MDLTQQEYIQ RFEQLKQELI
QSWHNDQRVK ALKIAIQCAK MLADTTVLQF YPSQYVLITD ILDVFGKLVY ERLRAKASGD
PAASAATLER EREAARDTCQ NWFYKIASIR ELLPRFYLEL SIFKCYEFLS SSREEYERIL
QRLTHQLRGI ADPLVSSYAR CYLVRMGVTL TSSKTYIREN FADLFLIYPQ IFRFVARFNL
HPEIVTASSY LQLYAPAFDY MLLCLVHKSE LHTQDILNEC KQLKNNGAIL MSVLSSFNSE
FIATNALEFI ALINASETPG ISKSQLLRSL GSCVSSCPPL QEQRVTFLKA AFETINKLTD
PNEYINCVET WAVFVSQYFT IHEVNRLLGE LNTRMCLGKA YEKHYSQLQN ILTRIMQNYR
SIELLLIQPN FLPYLDLFQK ESVRVEVCKN ILSFYKQNSD EYTCDAVVTN ALMYLGKILN
DSVNALSVDD ERRQIAQLIN VFIHKVHFGN DLEQQLSFYV EARGTFSNLD AVYVTLVHAA
CKLATRNRSK STGFVKACIA YCFITIPSIE AVQQQMNLYL LCGQLALQHL CLGQADACFE
AALQLVNELP AATVDFDGKP RSLEPFLVSY MCNILATLIV VPDSPEQGVL YFLRLLLEVV
GRHKFKVDSS APSIIYLHSL DMLYVQSLER FPYHIKGVVS NDDLYGHDPK FLQEVNNMCA
QVVDAILLQL KSLGVAQQQR SQAELALELF LRIVKYADLE RETIAQLAVN LWLLANKAQS
QLDVKTLPQT LRSVEIIYKQ IKDASPIRAQ TIAKLLLRVR SS
