ID   VP35_MABVR              Reviewed;         329 AA.
AC   Q1PDC9; O36426;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Polymerase cofactor VP35;
DE   AltName: Full=Marburg VP35;
DE            Short=mVP35;
GN   Name=VP35;
OS   Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain
OS   Kenya/Ravn/1987)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Filoviridae; Marburgvirus.
OX   NCBI_TaxID=378809;
OH   NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9407; Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9448698; DOI=10.1006/viro.1997.8902;
RA   Sanchez A., Trappier S.G., Stroeher U., Nichol S.T., Bowen M.D.,
RA   Feldmann H.;
RT   "Variation in the glycoprotein and VP35 genes of Marburg virus strains.";
RL   Virology 240:138-146(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16775337; DOI=10.1128/jvi.00069-06;
RA   Towner J.S., Khristova M.L., Sealy T.K., Vincent M.J., Erickson B.R.,
RA   Bawiec D.A., Hartman A.L., Comer J.A., Zaki S.R., Stroeher U.,
RA   Gomes da Silva F., del Castillo F., Rollin P.E., Ksiazek T.G., Nichol S.T.;
RT   "Marburgvirus genomics and association with a large hemorrhagic fever
RT   outbreak in Angola.";
RL   J. Virol. 80:6497-6516(2006).
CC   -!- FUNCTION: Plays an essential role in viral RNA synthesis and also a
CC       role in suppressing innate immune signaling.
CC       {ECO:0000250|UniProtKB:P35259}.
CC   -!- SUBUNIT: Homooligomer. Homomultimerization via the coiled coil domain
CC       is a prerequisite for binding to L. Found in a trimeric complex in
CC       which VP35 bridges L and the nucleoprotein (By similarity). Interacts
CC       with NP (By similarity). Disrupts innate immune signaling in infected
CC       host cell (By similarity). {ECO:0000250|UniProtKB:P35259,
CC       ECO:0000250|UniProtKB:Q6UY68}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P35259}. Host
CC       cytoplasm {ECO:0000250|UniProtKB:P35259}.
CC   -!- SIMILARITY: Belongs to the filoviridae polymerase cofactor VP35 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01071, ECO:0000305}.
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DR   EMBL; AF005731; AAC40456.1; -; Genomic_RNA.
DR   EMBL; DQ447649; ABE27069.1; -; Genomic_RNA.
DR   SMR; Q1PDC9; -.
DR   Proteomes; UP000008239; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.8.950; -; 1.
DR   Gene3D; 2.10.10.70; -; 1.
DR   InterPro; IPR002953; Filo_VP35.
DR   InterPro; IPR031163; VP35_IID.
DR   InterPro; IPR043061; VP35_IID_b-sht.
DR   InterPro; IPR043060; VP35_IID_hlx.
DR   Pfam; PF02097; Filo_VP35; 1.
DR   PIRSF; PIRSF018326; VP35_FiloV; 1.
DR   PRINTS; PR01240; FILOVP35.
DR   PROSITE; PS51735; VP35_IID; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Host cytoplasm; Reference proteome; Transcription;
KW   Viral RNA replication; Virion.
FT   CHAIN           1..329
FT                   /note="Polymerase cofactor VP35"
FT                   /id="PRO_0000314997"
FT   DOMAIN          204..329
FT                   /note="VP35 IID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01071"
FT   COILED          70..120
FT                   /evidence="ECO:0000255"
FT   VARIANT         42
FT                   /note="T -> P (in strain: Isolate Sanchez)"
SQ   SEQUENCE   329 AA;  36243 MW;  F5DC6BCF39178E3A CRC64;
     MWDSSYMQQV SEGLMTGKVP IDQVFGTNPL EKLYKRRKPK GTVGLQCSPC LISKSTSTDD
     IVWDQLIVKK TLADLLIPIN RQMSDIQSTL SEMTTKVHEI ERQLHDITPV VKMGKTLEAI
     SKGMSEMLAK YDHLVISTGR TTAPAAAFDA YLNEHGVPPP QPAIFKDLGV AQQAYSQKTM
     VKNQTTDAAD KMSKVLELSE ETFSKPNLSA KDLALLLFTH LPGNNTPFHI LAQVLSKIAY
     KSGKSGAFLD AFHQILSEGE NAQAALTRLS RTFDAFLGAV PPVIKVKNFQ TVPRPCQKSL
     RAVPPNPTID KGWVCVYSSE QGETRALKI