ID   VP35_NPVBM              Reviewed;         299 AA.
AC   P31354;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   29-SEP-2021, entry version 95.
DE   RecName: Full=Early 35 kDa protein;
DE   AltName: Full=Apoptosis-preventing protein;
DE   AltName: Full=p35;
GN   Name=P35;
OS   Bombyx mori nuclear polyhedrosis virus (BmNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=271108;
OH   NCBI_TaxID=7091; Bombyx mori (Silk moth).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=T3;
RX   PubMed=8416377; DOI=10.1128/jvi.67.1.455-463.1993;
RA   Kamita S.G., Majima K., Maeda S.;
RT   "Identification and characterization of the p35 gene of Bombyx mori nuclear
RT   polyhedrosis virus that prevents virus-induced apoptosis.";
RL   J. Virol. 67:455-463(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T3;
RX   PubMed=10355780; DOI=10.1099/0022-1317-80-5-1323;
RA   Gomi S., Majima K., Maeda S.;
RT   "Sequence analysis of the genome of Bombyx mori nucleopolyhedrovirus.";
RL   J. Gen. Virol. 80:1323-1337(1999).
CC   -!- FUNCTION: Blocks the insect or worm host cells apoptotic response
CC       initiated by the viral infection. Confers protection from cell death in
CC       mammalian cells. Acts by blocking the activity of members of the
CC       caspase family of proteases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I50 (p35) family.
CC       {ECO:0000305}.
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DR   EMBL; L04802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; L33180; AAC63802.1; -; Genomic_DNA.
DR   PIR; A45720; A45720.
DR   RefSeq; NP_047533.1; NC_001962.1.
DR   SMR; P31354; -.
DR   GeneID; 1488744; -.
DR   KEGG; vg:1488744; -.
DR   Proteomes; UP000204315; Genome.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:GOC.
DR   GO; GO:0039650; P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.250.10; -; 1.
DR   InterPro; IPR003429; Baculovirus_p35.
DR   InterPro; IPR036562; Baculovirus_p35_sf.
DR   Pfam; PF02331; P35; 1.
DR   SUPFAM; SSF49894; SSF49894; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Early protein; Host-virus interaction;
KW   Inhibition of host caspases by virus;
KW   Modulation of host cell apoptosis by virus; Protease inhibitor;
KW   Thiol protease inhibitor.
FT   CHAIN           1..299
FT                   /note="Early 35 kDa protein"
FT                   /id="PRO_0000132899"
SQ   SEQUENCE   299 AA;  34912 MW;  63C3B2AF366D9093 CRC64;
     MCVIFPVEID VSQTVIRDCH VDEQTRELVY INKIMNTQLT KPVLMMFNIS GPIRSVTRKN
     NDLRDRIKSK VDEQFDQLER EYSDKIDGFH DNIQYFKDEH YSVSCQNGSV LKSKFAKILK
     SHDYTDKKSI ETYEKYCLPQ LVDKHNDCYV AVCVLKPGFE NGSNQVLSFE YNPIGNKVIV
     PFAHEINDTG LYEYDVLAYV DSVEFDGKQF EEFVQKLILP SSFNDSEKVL YYNEASKNKN
     MIYKALEFTT ESSWVKSNKF NWKIFCNGFI YDKKSKALYV KLHNVTSTLN KNVILDMIK