VP37C_HUMAN
ID VP37C_HUMAN Reviewed; 355 AA.
AC A5D8V6; Q8N3K4;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Vacuolar protein sorting-associated protein 37C;
DE Short=hVps37C;
DE AltName: Full=ESCRT-I complex subunit VPS37C;
GN Name=VPS37C; Synonyms=PML39;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-182.
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-198.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-198.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, INTERACTION WITH HGS; STAM2 AND TSG101, AND SUBCELLULAR LOCATION.
RX PubMed=15509564; DOI=10.1074/jbc.m410384200;
RA Eastman S.W., Martin-Serrano J., Chung W., Zang T., Bieniasz P.D.;
RT "Identification of human VPS37C, a component of endosomal sorting complex
RT required for transport-I important for viral budding.";
RL J. Biol. Chem. 280:628-636(2005).
RN [6]
RP INTERACTION WITH TSG101; VPS28; MVB12A AND MVB12B, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18005716; DOI=10.1016/j.chom.2007.06.003;
RA Morita E., Sandrin V., Alam S.L., Eckert D.M., Gygi S.P., Sundquist W.I.;
RT "Identification of human MVB12 proteins as ESCRT-I subunits that function
RT in HIV budding.";
RL Cell Host Microbe 2:41-53(2007).
RN [7]
RP INTERACTION WITH CEP55.
RX PubMed=17853893; DOI=10.1038/sj.emboj.7601850;
RA Morita E., Sandrin V., Chung H.Y., Morham S.G., Gygi S.P., Rodesch C.K.,
RA Sundquist W.I.;
RT "Human ESCRT and ALIX proteins interact with proteins of the midbody and
RT function in cytokinesis.";
RL EMBO J. 26:4215-4227(2007).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP PHOSPHORYLATION BY TBK1.
RX PubMed=21270402; DOI=10.4049/jimmunol.1000262;
RA Da Q., Yang X., Xu Y., Gao G., Cheng G., Tang H.;
RT "TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through
RT targeting endosomal sorting complex required for transport-I.";
RL J. Immunol. 186:3023-3030(2011).
RN [10]
RP IDENTIFICATION IN AN ESCRT-I COMPLEX WITH UBAP1, AND SUBUNIT.
RX PubMed=22405001; DOI=10.1016/j.str.2011.12.013;
RA Agromayor M., Soler N., Caballe A., Kueck T., Freund S.M., Allen M.D.,
RA Bycroft M., Perisic O., Ye Y., McDonald B., Scheel H., Hofmann K.,
RA Neil S.J., Martin-Serrano J., Williams R.L.;
RT "The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA
RT domain.";
RL Structure 20:414-428(2012).
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000269|PubMed:15509564}.
CC -!- SUBUNIT: Component of the ESCRT-I complex (endosomal sorting complex
CC required for transport I) which consists of TSG101, VPS28, a VPS37
CC protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry.
CC Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the
CC ESCRT-I complex (endosomal sorting complex required for transport I)
CC which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and
CC UBAP1 in a 1:1:1:1 stoichiometry. Interacts with HGS and STAM2.
CC Interacts with CEP55. {ECO:0000269|PubMed:15509564,
CC ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18005716,
CC ECO:0000269|PubMed:22405001}.
CC -!- INTERACTION:
CC A5D8V6; Q4LEZ3: AARD; NbExp=3; IntAct=EBI-2559305, EBI-5463075;
CC A5D8V6; Q8NFV4-4: ABHD11; NbExp=3; IntAct=EBI-2559305, EBI-12318443;
CC A5D8V6; Q9NQ33: ASCL3; NbExp=3; IntAct=EBI-2559305, EBI-12108222;
CC A5D8V6; O95429: BAG4; NbExp=3; IntAct=EBI-2559305, EBI-2949658;
CC A5D8V6; Q96CA5: BIRC7; NbExp=3; IntAct=EBI-2559305, EBI-517623;
CC A5D8V6; Q6P1W5: C1orf94; NbExp=6; IntAct=EBI-2559305, EBI-946029;
CC A5D8V6; Q53EZ4: CEP55; NbExp=8; IntAct=EBI-2559305, EBI-747776;
CC A5D8V6; O43186: CRX; NbExp=3; IntAct=EBI-2559305, EBI-748171;
CC A5D8V6; Q15038: DAZAP2; NbExp=6; IntAct=EBI-2559305, EBI-724310;
CC A5D8V6; O75935-2: DCTN3; NbExp=3; IntAct=EBI-2559305, EBI-12091947;
CC A5D8V6; P35638: DDIT3; NbExp=3; IntAct=EBI-2559305, EBI-742651;
CC A5D8V6; P35638-2: DDIT3; NbExp=3; IntAct=EBI-2559305, EBI-10173632;
CC A5D8V6; Q8WWB3: DYDC1; NbExp=3; IntAct=EBI-2559305, EBI-740680;
CC A5D8V6; O00167-2: EYA2; NbExp=3; IntAct=EBI-2559305, EBI-12807776;
CC A5D8V6; Q92567: FAM168A; NbExp=3; IntAct=EBI-2559305, EBI-7957930;
CC A5D8V6; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-2559305, EBI-12193763;
CC A5D8V6; B7ZLH0: FAM22F; NbExp=3; IntAct=EBI-2559305, EBI-10220102;
CC A5D8V6; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-2559305, EBI-11958845;
CC A5D8V6; Q12951-2: FOXI1; NbExp=6; IntAct=EBI-2559305, EBI-12018822;
CC A5D8V6; Q96AE4-2: FUBP1; NbExp=3; IntAct=EBI-2559305, EBI-12121668;
CC A5D8V6; Q08379: GOLGA2; NbExp=3; IntAct=EBI-2559305, EBI-618309;
CC A5D8V6; Q13227: GPS2; NbExp=3; IntAct=EBI-2559305, EBI-713355;
CC A5D8V6; P62993: GRB2; NbExp=3; IntAct=EBI-2559305, EBI-401755;
CC A5D8V6; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-2559305, EBI-2514791;
CC A5D8V6; A0A087WSW0: HELT; NbExp=3; IntAct=EBI-2559305, EBI-12057631;
CC A5D8V6; O14964: HGS; NbExp=3; IntAct=EBI-2559305, EBI-740220;
CC A5D8V6; P52597: HNRNPF; NbExp=3; IntAct=EBI-2559305, EBI-352986;
CC A5D8V6; Q9BUJ2: HNRNPUL1; NbExp=3; IntAct=EBI-2559305, EBI-1018153;
CC A5D8V6; Q12906-6: ILF3; NbExp=3; IntAct=EBI-2559305, EBI-12904528;
CC A5D8V6; Q13351: KLF1; NbExp=3; IntAct=EBI-2559305, EBI-8284732;
CC A5D8V6; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-2559305, EBI-3044087;
CC A5D8V6; Q14525: KRT33B; NbExp=3; IntAct=EBI-2559305, EBI-1049638;
CC A5D8V6; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-2559305, EBI-11992140;
CC A5D8V6; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-2559305, EBI-1048945;
CC A5D8V6; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-2559305, EBI-12805508;
CC A5D8V6; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-2559305, EBI-10241353;
CC A5D8V6; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-2559305, EBI-12111050;
CC A5D8V6; Q3LI66: KRTAP6-2; NbExp=5; IntAct=EBI-2559305, EBI-11962084;
CC A5D8V6; Q8IUC3: KRTAP7-1; NbExp=3; IntAct=EBI-2559305, EBI-18394498;
CC A5D8V6; Q14657: LAGE3; NbExp=3; IntAct=EBI-2559305, EBI-1052105;
CC A5D8V6; Q14847-2: LASP1; NbExp=3; IntAct=EBI-2559305, EBI-9088686;
CC A5D8V6; Q8NDC0: MAPK1IP1L; NbExp=6; IntAct=EBI-2559305, EBI-741424;
CC A5D8V6; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-2559305, EBI-8487781;
CC A5D8V6; Q96HA8: NTAQ1; NbExp=6; IntAct=EBI-2559305, EBI-741158;
CC A5D8V6; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-2559305, EBI-741048;
CC A5D8V6; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-2559305, EBI-10181968;
CC A5D8V6; P55771: PAX9; NbExp=3; IntAct=EBI-2559305, EBI-12111000;
CC A5D8V6; O75340: PDCD6; NbExp=6; IntAct=EBI-2559305, EBI-352915;
CC A5D8V6; Q9UBV8: PEF1; NbExp=3; IntAct=EBI-2559305, EBI-724639;
CC A5D8V6; P55347: PKNOX1; NbExp=4; IntAct=EBI-2559305, EBI-1373569;
CC A5D8V6; Q96I87: PKNOX1; NbExp=3; IntAct=EBI-2559305, EBI-10173774;
CC A5D8V6; Q96KN3: PKNOX2; NbExp=5; IntAct=EBI-2559305, EBI-2692890;
CC A5D8V6; O15496: PLA2G10; NbExp=3; IntAct=EBI-2559305, EBI-726466;
CC A5D8V6; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-2559305, EBI-949255;
CC A5D8V6; O15162: PLSCR1; NbExp=3; IntAct=EBI-2559305, EBI-740019;
CC A5D8V6; P52435: POLR2J; NbExp=3; IntAct=EBI-2559305, EBI-394753;
CC A5D8V6; Q9H1A7: POLR2J3; NbExp=3; IntAct=EBI-2559305, EBI-12818681;
CC A5D8V6; Q16633: POU2AF1; NbExp=3; IntAct=EBI-2559305, EBI-943588;
CC A5D8V6; P86480: PRR20D; NbExp=3; IntAct=EBI-2559305, EBI-12754095;
CC A5D8V6; P25788: PSMA3; NbExp=3; IntAct=EBI-2559305, EBI-348380;
CC A5D8V6; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-2559305, EBI-744023;
CC A5D8V6; Q93062: RBPMS; NbExp=3; IntAct=EBI-2559305, EBI-740322;
CC A5D8V6; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-2559305, EBI-740343;
CC A5D8V6; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-2559305, EBI-11987469;
CC A5D8V6; Q8HWS3: RFX6; NbExp=3; IntAct=EBI-2559305, EBI-746118;
CC A5D8V6; Q8N443: RIBC1; NbExp=6; IntAct=EBI-2559305, EBI-10265323;
CC A5D8V6; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-2559305, EBI-726876;
CC A5D8V6; Q9NQG5: RPRD1B; NbExp=3; IntAct=EBI-2559305, EBI-747925;
CC A5D8V6; Q01196-8: RUNX1; NbExp=3; IntAct=EBI-2559305, EBI-12001422;
CC A5D8V6; Q6FGM0: SH3GL1; NbExp=3; IntAct=EBI-2559305, EBI-10173690;
CC A5D8V6; Q99961: SH3GL1; NbExp=3; IntAct=EBI-2559305, EBI-697911;
CC A5D8V6; Q8TEC5: SH3RF2; NbExp=3; IntAct=EBI-2559305, EBI-2130111;
CC A5D8V6; O94875: SORBS2; NbExp=3; IntAct=EBI-2559305, EBI-311323;
CC A5D8V6; O94875-10: SORBS2; NbExp=3; IntAct=EBI-2559305, EBI-12037893;
CC A5D8V6; O60504: SORBS3; NbExp=6; IntAct=EBI-2559305, EBI-741237;
CC A5D8V6; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-2559305, EBI-11959123;
CC A5D8V6; O75886: STAM2; NbExp=6; IntAct=EBI-2559305, EBI-373258;
CC A5D8V6; Q8IWL8: STH; NbExp=3; IntAct=EBI-2559305, EBI-12843506;
CC A5D8V6; Q9Y6A5: TACC3; NbExp=3; IntAct=EBI-2559305, EBI-2554984;
CC A5D8V6; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-2559305, EBI-11952651;
CC A5D8V6; Q92734: TFG; NbExp=6; IntAct=EBI-2559305, EBI-357061;
CC A5D8V6; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-2559305, EBI-1105213;
CC A5D8V6; Q01085-2: TIAL1; NbExp=3; IntAct=EBI-2559305, EBI-11064654;
CC A5D8V6; Q08117: TLE5; NbExp=3; IntAct=EBI-2559305, EBI-717810;
CC A5D8V6; Q08117-2: TLE5; NbExp=3; IntAct=EBI-2559305, EBI-11741437;
CC A5D8V6; Q86WV8: TSC1; NbExp=3; IntAct=EBI-2559305, EBI-12806590;
CC A5D8V6; Q99816: TSG101; NbExp=6; IntAct=EBI-2559305, EBI-346882;
CC A5D8V6; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-2559305, EBI-2514383;
CC A5D8V6; Q6NVU6: UFSP1; NbExp=3; IntAct=EBI-2559305, EBI-12068150;
CC A5D8V6; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-2559305, EBI-12040603;
CC A5D8V6; O00308: WWP2; NbExp=6; IntAct=EBI-2559305, EBI-743923;
CC A5D8V6; P98170: XIAP; NbExp=7; IntAct=EBI-2559305, EBI-517127;
CC A5D8V6; Q9BYJ9: YTHDF1; NbExp=3; IntAct=EBI-2559305, EBI-1051237;
CC A5D8V6; Q9UDW3: ZMAT5; NbExp=3; IntAct=EBI-2559305, EBI-7850213;
CC A5D8V6; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-2559305, EBI-12030590;
CC A5D8V6; G4XUV3; NbExp=3; IntAct=EBI-2559305, EBI-10177989;
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000305|PubMed:15509564}; Peripheral membrane protein
CC {ECO:0000305|PubMed:15509564}. Note=Probably associates with membranes.
CC Recruited to the plasma membrane by HIV-1.
CC -!- PTM: Phosphorylated by TBK1. {ECO:0000269|PubMed:21270402}.
CC -!- SIMILARITY: Belongs to the VPS37 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD38936.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL834261; CAD38936.1; ALT_INIT; mRNA.
DR EMBL; AP000437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471076; EAW73925.1; -; Genomic_DNA.
DR EMBL; BC141827; AAI41828.1; -; mRNA.
DR EMBL; BC142702; AAI42703.1; -; mRNA.
DR CCDS; CCDS31573.1; -.
DR RefSeq; NP_060436.4; NM_017966.4.
DR RefSeq; XP_005274134.1; XM_005274077.3.
DR AlphaFoldDB; A5D8V6; -.
DR SMR; A5D8V6; -.
DR BioGRID; 120371; 142.
DR ComplexPortal; CPX-7147; ESCRT-I complex, VPS37C-MVB12A variant.
DR ComplexPortal; CPX-7166; ESCRT-I complex, VPS37C-MVB12B variant.
DR ComplexPortal; CPX-7202; ESCRT-I complex, VPS37C-UBAP1 variant.
DR CORUM; A5D8V6; -.
DR IntAct; A5D8V6; 99.
DR MINT; A5D8V6; -.
DR STRING; 9606.ENSP00000301765; -.
DR MoonDB; A5D8V6; Predicted.
DR iPTMnet; A5D8V6; -.
DR PhosphoSitePlus; A5D8V6; -.
DR BioMuta; VPS37C; -.
DR EPD; A5D8V6; -.
DR jPOST; A5D8V6; -.
DR MassIVE; A5D8V6; -.
DR MaxQB; A5D8V6; -.
DR PaxDb; A5D8V6; -.
DR PeptideAtlas; A5D8V6; -.
DR PRIDE; A5D8V6; -.
DR ProteomicsDB; 712; -.
DR Antibodypedia; 28060; 153 antibodies from 28 providers.
DR DNASU; 55048; -.
DR Ensembl; ENST00000301765.10; ENSP00000301765.5; ENSG00000167987.11.
DR GeneID; 55048; -.
DR KEGG; hsa:55048; -.
DR MANE-Select; ENST00000301765.10; ENSP00000301765.5; NM_017966.5; NP_060436.4.
DR UCSC; uc001nqv.2; human.
DR CTD; 55048; -.
DR DisGeNET; 55048; -.
DR GeneCards; VPS37C; -.
DR HGNC; HGNC:26097; VPS37C.
DR HPA; ENSG00000167987; Low tissue specificity.
DR MIM; 610038; gene.
DR neXtProt; NX_A5D8V6; -.
DR OpenTargets; ENSG00000167987; -.
DR PharmGKB; PA142670617; -.
DR VEuPathDB; HostDB:ENSG00000167987; -.
DR eggNOG; KOG3270; Eukaryota.
DR GeneTree; ENSGT00950000183012; -.
DR HOGENOM; CLU_067118_0_0_1; -.
DR InParanoid; A5D8V6; -.
DR OMA; PMYRAGY; -.
DR OrthoDB; 1197293at2759; -.
DR PhylomeDB; A5D8V6; -.
DR TreeFam; TF321840; -.
DR PathwayCommons; A5D8V6; -.
DR Reactome; R-HSA-162588; Budding and maturation of HIV virion.
DR Reactome; R-HSA-174490; Membrane binding and targetting of GAG proteins.
DR Reactome; R-HSA-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR Reactome; R-HSA-9610379; HCMV Late Events.
DR Reactome; R-HSA-9615710; Late endosomal microautophagy.
DR SignaLink; A5D8V6; -.
DR BioGRID-ORCS; 55048; 92 hits in 1081 CRISPR screens.
DR ChiTaRS; VPS37C; human.
DR GenomeRNAi; 55048; -.
DR Pharos; A5D8V6; Tbio.
DR PRO; PR:A5D8V6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A5D8V6; protein.
DR Bgee; ENSG00000167987; Expressed in secondary oocyte and 198 other tissues.
DR ExpressionAtlas; A5D8V6; baseline and differential.
DR Genevisible; A5D8V6; HS.
DR GO; GO:0010008; C:endosome membrane; TAS:Reactome.
DR GO; GO:0000813; C:ESCRT I complex; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048306; F:calcium-dependent protein binding; IPI:UniProtKB.
DR GO; GO:0016236; P:macroautophagy; TAS:ParkinsonsUK-UCL.
DR GO; GO:0090148; P:membrane fission; IC:ComplexPortal.
DR GO; GO:0036258; P:multivesicular body assembly; TAS:ParkinsonsUK-UCL.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IC:ComplexPortal.
DR GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0039702; P:viral budding via host ESCRT complex; TAS:ParkinsonsUK-UCL.
DR Gene3D; 1.10.287.660; -; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009851; Mod_r.
DR Pfam; PF07200; Mod_r; 1.
DR SUPFAM; SSF140111; SSF140111; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 1: Evidence at protein level;
KW Endosome; Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..355
FT /note="Vacuolar protein sorting-associated protein 37C"
FT /id="PRO_0000312198"
FT DOMAIN 78..167
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00646"
FT REGION 159..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..231
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..355
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 29
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R105"
FT VARIANT 182
FT /note="V -> D (in dbSNP:rs2232142)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_037451"
FT VARIANT 198
FT /note="L -> S (in dbSNP:rs754382)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_037452"
SQ SEQUENCE 355 AA; 38659 MW; 1DE18F0E4C7C7E2E CRC64;
METLKDKTLQ ELEELQNDSE AIDQLALESP EVQDLQLERE MALATNRSLA ERNLEFQGPL
EISRSNLSDR YQELRKLVER CQEQKAKLEK FSSALQPGTL LDLLQVEGMK IEEESEAMAE
KFLEGEVPLE TFLENFSSMR MLSHLRRVRV EKLQEVVRKP RASQELAGDA PPPRPPPPVR
PVPQGTPPVV EEQPQPPLAM PPYPLPYSPS PSLPVGPTAH GALPPAPFPV VSQPSFYSGP
LGPTYPAAQL GPRGAAGYSW SPQRSMPPRP GYPGTPMGAS GPGYPLRGGR APSPGYPQQS
PYPATGGKPP YPIQPQLPSF PGQPQPSVPL QPPYPPGPAP PYGFPPPPGP AWPGY
